Corchorus olitorius L. ameliorates alcoholic liver disease by regulating gut-liver axis

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

“…The abnormal increase of serum TC, TG, LDL-C, AST, ALT levels, and the abnormal decrease of serum HDL-C levels are the main characteristics in mice with alcoholic liver injury ( Do et al, 2021 ). In this study, excessive alcohol consumption markedly increased the serum TC, TG, LDL-C, AST, ALT levels ( p < 0.05), and significantly reduced the serum HDL-C level ( p < 0.05), indicating the liver metabolic function was destroyed in the mice with excessive alcohol intake ( Fig.…”

Histamine Causes Pyroptosis of Liver by Regulating Gut-Liver Axis in Mice

“…The mice model is one of the commonly used models to investigate liver damage and has long been used to evaluate the pathological process of alcoholic liver disease (ALD) [ 17 ], nonalcoholic liver disease (NALD) [ 11 ], and other liver injuries [ 10 ]. Compared with gavage, intraperitoneal injection greatly shortens the modeling cycle, but there is a higher risk of death concurrently [ 18 ].…”

“…Recently, more and more studies have shown that the gut-liver axis plays a crucial role in hepatic disorders [ 8 ]. The underlying molecular mechanism may be that the constitution of the gut microbiome and its metabolites affect the pathophysiology of the liver, such as short-chain fatty acids (SCFAs), bile acids (BAs), choline, and lipopolysaccharides (LPS) [ 10 , 11 , 12 ]. Meanwhile, the liver components can affect liver health via influencing the community and function of the gut microbiota [ 13 ].…”

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

“…Polysaccharides are polymeric carbohydrate molecules abundantly present in various plants, algae, microorganisms, and animals, exerting a wide array of biological activities, including hepatoprotective activities [ 73 ]. Many authors reported that polysaccharides could protect the liver from alcohol damage via multiple pathways, including restoring gut dysbiosis [ 32 , 74 , 75 , 76 ]. In detail, Wang et al isolated polysaccharides from garlic (molecular weight: 10 Kda, acid heteropolysaccharide), which was further studied against ALD in mice.…”

“…In another study, pomegranate extract could also prevent intestinal apoptosis, endotoxemia, alcohol-induced intestinal leakage, and inflammation by regulating TJ/ adherent junction proteins [ 80 ]. Corchorus olitorius L., also known as molokhia, is a pantropical plant consumed as a vegetable in Africa and Eastern Asia that exerts a protective effect against several diseases [ 76 , 81 ]. Recently, Do et al documented that administration of molokhia extract (50 and 100 mg/kg bw) restored the composition of Muribaculum and enhanced the intestinal barrier function in mice [ 76 ].…”