The CDR target of the National Tuberculosis Control Program is 100%. In 2015, the incident rate as the basis for setting the case detection rate (CDR) target was 107 per 100,000 population, while in 2016, it jumped sharply 398 per 100,000 population. The incidence of tuberculosis in South Kalimantan in 2017 was 245 cases per 100,000 population, while in South Kalimantan, the CDR in 2018 was 54.5%. Based on data from the Banjar Regency Health Office, the number of TB cases in Banjar Regency in 2017 was 1,064 cases, while in 2016, there were 1,099 cases. In 2017, CDR is still below the national target of 42.79%. This study aims to analyze the factors of the level of education, training and workload of tuberculosis program officers who are related to the CDR at Community Health Center in the Banjar Regency. This research is a quantitative study using an analytic observational method with a cross-sectional study design. The number of samples in this study was 62 people with a proportional random sampling technique. The results of the study indicate there is a relationship between workload (p=0.034) with the performance of tuberculosis program officers in the CDR. There is no relationship between education level (p=0.258), training (p=0.094) with the performance of tuberculosis program officers in the CDR. In contrast, the dominant factor related to the performance of tuberculosis program officers in the CDR was workload (p=0.034).