Creating micro- and nanostructures on tubular and spherical surfaces

Lima, Ocelio V.; Tan, Li; Goel, Apoorva; Negahban, Mehrdad; Li, Z.

doi:10.1116/1.2804428

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…It has only recently been used in the micropatterning of ceramic green substrates . In addition to the advantage of cost‐effectiveness and capability of micropatterning in large areas, it can also be applied to nonplanar surfaces such as tubular and spherical surfaces by using a soft mould . Through use of a disposable hard polymer mould (e.g., PMMA), micropatterned ceramics with high aspect ratios can be created .…”

Section: Discussionmentioning

confidence: 99%

“…31 In addition to the advantage of cost-effectiveness and capability of micropatterning in large areas, it can also be applied to nonplanar surfaces such as tubular and spherical surfaces by using a soft mould. 32 Through use of a disposable hard polymer mould (e.g., PMMA), micropatterned ceramics with high aspect ratios can be created. 33,34 It is therefore possible to create micropatterns on complex ceramics using either hard embossing or soft moulding, depending on the shape and dimension of implant or prostheses.…”

Section: Discussionmentioning

confidence: 99%

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Embossing of micropatterned ceramics and their cellular response

Nadeem

Sjöström

Wilkinson

et al. 2013

J Biomedical Materials Res

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The aim of this work is to investigate the use of microtopographies in providing physical cues to modulate the cellular response of human mesenchymal stem cells on ceramics. Two microgrooved patterns (100 μm/50 μm, 10 μm/10 μm groove/pitch) were transcribed reversely onto alumina green ceramic tapes via an embossing technique followed by sintering. Characterization of the micropatterned alumina surfaces and their cellular response was carried out. Spread and polygonal cell morphologies were observed on the wider groove (50 μm/100 μm) surface. Cells seeded onto the narrow groove (10 μm/10 μm) surface aligned themselves alongside the grooves, resulting in more elongated cell morphology. More osteoid matrix nodules shown by osteopontin and osteocalcin biomarkers were detected on the larger grooved surfaces after cell culture of 21 days, indicating a greater level of osteogenicity. This study has shown that micropatterned wider groove (50 μm) topographies are more suitable surfaces for improving osseointegration of ceramic implants.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Embossing of micropatterned ceramics and their cellular response

Nadeem

Sjöström

Wilkinson

et al. 2013

J Biomedical Materials Res

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“…The bio-hybrid structure was virtually reproduced as a rolled 15 × 10 mm 2 sheet, with bilayer thicknesses of 10, 15 and 25 μm, respectively (figure 2). The spiral internal radius was set by using the following formula [56]: The presence of the pillars was taken into consideration by adding small parallelepipeds with size of 0.03 × 0.06 × 0.30 mm 3 each, while the micro-grooves were neglected in this analysis (their height is much lower respect the height of pillars, as later showed in section 3.1). The PDMS material was modeled by using PENTA elements with full integration and the mechanical characteristics of the material were set resembling the real ones.…”

Section: Fem Simulationsmentioning

confidence: 99%

Self-assembly of polydimethylsiloxane structures from 2D to 3D for bio-hybrid actuation

et al. 2015

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This work aims to demonstrate the feasibility of a novel approach for the development of 3D self-assembled polydimethylsiloxane structures, to be used as engineered flexible matrices for bio-hybrid actuation. We described the fabrication of engineered bilayers, organized in a 3D architecture by means of a stress-induced rolling membrane technique. Such structures were provided with ad hoc surface topographies, for both cell alignment and cell survival after membrane rolling. We reported the results of advanced finite element model simulations, predicting the system behavior in terms of overall contraction, induced by the contractile activity of muscle cells seeded on the membrane. Then, we tested in vitro the structure with primary cardiomyocytes to evaluate the real bio-actuator contraction, thus validating the simulation results. At a later stage, we provided the samples with a stable fibronectin coating, by covalently binding the protein on the polymer surface, thus enabling long-term cultures with C2C12 skeletal muscle cells, a more controllable cell type. These tests revealed cell viability and alignment on the rolled structures, but also the ability of cells to differentiate and to form multinucleated and oriented myotubes on the polymer surface, also supported by a fibroblast feeder layer. Our results highlighted the possibility of developing 3D rolled PDMS structures, characterized by different mechanical properties, as novel bio-hybrid actuators.

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“…The mCP process provides a convenient, quick, and inexpensive way of patterning SAMs. In addition, the SAMs can be coated onto curved surfaces by mCP because of the flexibility of the elastomeric stamp [118,119]. So, this method has become one of the most widely adopted approaches in AS-ALD.…”

Section: Microcontact Printingmentioning

confidence: 99%

Nanopatterning by Area‐Selective Atomic Layer Deposition

Lee

Bent

2011

Atomic Layer Deposition of Nanostructured Materials

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In conventional device fabrication, patterning is a top-down process based largely on photolithography and etching and is a main bottleneck for device downscaling. Atomic layer deposition (ALD) can provide an alternative bottom-up method for patterning when used in conjunction with self-assembled materials and selective chemistries. As presented in previous chapters, ALD is a powerful technique for depositing thin films for nanoscale device fabrication thanks to its excellent conformality, atomic scale thickness controllability, and large-area uniformity. Film growth controlled by surface reactions is one of the inherent properties of ALD. Because in an ideal ALD process, all of the precursors used for ALD react with each other only at the surface, highly conformal films can be deposited even inside complex 3D structures. By taking advantage of this inherent surface reaction property, ALD can be utilized for patterning based on a bottom-up process. In the following chapter, selective deposition methods will be presented. The contents include the surface modification techniques that are employed to exploit the surface reaction properties of ALD and related patterning processes with reported results. Concept of Area-Selective Atomic Layer DepositionFilm growth by ALD begins with formation of nuclei through a reaction of precursor molecules and surface species. Once nuclei are formed on a surface, the growth of the film may proceed by growth and coalescence of the nuclei, whereas if no nucleation occurs no film will be deposited. Therefore, the deposition characteristics of ALD strongly depend on the surface properties of the substrate. For example, in many cases, the nucleation of ALD is easy on hydrophilic OH-terminated substrates (e.g., SiO 2 ), while it is difficult on hydrophobic H-terminated surfaces (e.g., Si) [1][2][3][4]. Similarly, a nucleation delay in ALD, typically called the incubation time, is due to difficulty of nucleation at the surface. The nucleation delay and the variability of the growth characteristics depending on the surface can be problematic in typical thin

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Creating micro- and nanostructures on tubular and spherical surfaces

Cited by 12 publications

References 16 publications

Embossing of micropatterned ceramics and their cellular response

Embossing of micropatterned ceramics and their cellular response

Self-assembly of polydimethylsiloxane structures from 2D to 3D for bio-hybrid actuation

Nanopatterning by Area‐Selective Atomic Layer Deposition

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