Cryogenic 3D printed hydrogel scaffolds loading exosomes accelerate diabetic wound healing

Hu, Yiqiang; Wu, Bin; Xiong, Yuan; Tao, Ranyang; Panayi, Adriana C.; Chen, Lang; Tian, Wenqing; Xue, Hang; Shi, Lei; Zhang, Xianglin; Xiong, Liming; Mi, Bobin; Liu, Guohui

doi:10.1016/j.cej.2021.130634

Cited by 98 publications

(61 citation statements)

References 65 publications

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“…The fabricated SIS/MBG@Exos hydrogel scaffolds were shown to possess a 3D structure with appropriate porosity, biocompatibility, and hemostasis capability. The results of testing the scaffolds on diabetic wounds, confirmed that hydrogel scaffolds can accelerate diabetic wound healing by increasing blood flow and promoting the angiogenesis process of the diabetic wound [ 175 ]. H. Chen et al reported polyethylene glycol (PEG) wound dressings loaded with silver nitrate (AgNO 3 ) and the angiogenic drug, desferrioxamine (DFO) [ 176 ].…”

Section: Recent Developments In the 3d Printing Of Hydrogel Wound Dre...mentioning

confidence: 96%

“…Y. Hu et al used an extrusion-based cryogenic 3D printing technology to construct decellularized small intestinal submucosa (SIS) integrated with a mesoporous bioactive glass (MBG) and exosomes to produce a 3D scaffold dressing (SIS/MBG@Exos) that was capable of sustained release of bioactive exosomes [ 175 ]. The fabricated SIS/MBG@Exos hydrogel scaffolds were shown to possess a 3D structure with appropriate porosity, biocompatibility, and hemostasis capability.…”

Section: Recent Developments In the 3d Printing Of Hydrogel Wound Dre...mentioning

confidence: 99%

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Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

2022

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Wounds are a major health concern affecting the lives of millions of people. Some wounds may pass a threshold diameter to become unrecoverable by themselves. These wounds become chronic and may even lead to mortality. Recently, 3D printing technology, in association with biocompatible hydrogels, has emerged as a promising platform for developing smart wound dressings, overcoming several challenges. 3D printed wound dressings can be loaded with a variety of items, such as antibiotics, antibacterial nanoparticles, and other drugs that can accelerate wound healing rate. 3D printing is computerized, allowing each level of the printed part to be fully controlled in situ to produce the dressings desired. In this review, recent developments in hydrogel-based wound dressings made using 3D printing are covered. The most common biosensors integrated with 3D printed hydrogels for wound dressing applications are comprehensively discussed. Fundamental challenges for 3D printing and future prospects are highlighted. Additionally, some related nanomaterial-based hydrogels are recommended for future consideration.

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Section: Recent Developments In the 3d Printing Of Hydrogel Wound Dre...mentioning

confidence: 96%

Section: Recent Developments In the 3d Printing Of Hydrogel Wound Dre...mentioning

confidence: 99%

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

2022

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“…It was reported that SF-based biomaterials could enhance cartilage/osteochondral repair by loading bioactive materials 181 . For example, Wang et al synthesized SF/HA scaffolds functionalized with non-immunogenic aptamer (Apt19s) 182 .…”

Section: The Application Of Sf-based Biomaterials For Cartilage/osteo...mentioning

confidence: 99%

Silk fibroin-based biomaterials for cartilage/osteochondral repair

Zhou¹,

Cui²,

Wu³

et al. 2022

Theranostics

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Osteoarthritis (OA) is a common joint disease with a high disability rate. In addition, OA not only causes great physiological and psychological harm to patients, but also puts great pressure on the social healthcare system. Pathologically, the disintegration of cartilage and the lesions of subchondral bone are related to OA. Currently, tissue engineering, which is expected to overcome the defects of existing treatment methods, had a lot of research in the field of cartilage/osteochondral repair. Silk fibroin (SF), as a natural macromolecular material with good biocompatibility, unique mechanical properties, excellent processability and degradability, holds great potential in the field of tissue engineering. Nowadays, SF had been prepared into various materials to adapt to the demands of cartilage/osteochondral repair. SF-based biomaterials can also be functionally modified to enhance repair performance further. In this review, the preparation methods, types, structures, mechanical properties, and functional modifications of SF-based biomaterials used for cartilage/osteochondral repair are summarized and discussed. We hope that this review will provide a reference for the design and development of SF-based biomaterials in cartilage/osteochondral repair field.

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“…Due to the existence of an ordered macroporous structure, 3D printing-based hydrogel showed better wound healing by improving the expression of ASCs behaviors in scaffolds Hu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Direct three-dimensional printed egg white hydrogel wound dressing promotes wound healing with hitching adipose stem cells

Wang

Niu

et al. 2022

Front. Bioeng. Biotechnol.

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Current wound dressing based on hydrogel offers a promising way to accelerate the healing process, yet great challenges remain in the development of a highly integrated and efficient platform with the combination of therapeutic biomolecules and stem cells. Herein, a natural hydrogel wound dressing from egg white can be conveniently obtained by feasible physical crosslinking, the prepared hydrogel dressing features interconnected microporous channels, direct 3D printing, cytocompatibility, and intrinsic biomolecules to advance cell behavior. The 3D printed egg white hydrogels promote the adhesion and proliferation of adipose-derived stem cells (ASCs) without obvious cytotoxicity. In addition, this integrated hydrogel platform accompanied with adipose-derived stem cells accelerates wound healing through the enhancement of fibroblast proliferation, angiogenesis, and collagen rearrangement in the wound bed. The egg white hydrogel provides an effective wound caring product possessing low cost, easy availability along with ready manufacturing, and advanced therapeutic effect, which may be extended for the management of chronic or other complicated wounds.

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Cryogenic 3D printed hydrogel scaffolds loading exosomes accelerate diabetic wound healing

Cited by 98 publications

References 65 publications

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

Silk fibroin-based biomaterials for cartilage/osteochondral repair

Direct three-dimensional printed egg white hydrogel wound dressing promotes wound healing with hitching adipose stem cells

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