Crystal structure of<i>cis</i>-1-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)azepan-2-one

In the title compound, C18H13F2NO2, the two rings of the quinoline system are fused almost coaxially, with a dihedral angle between their planes of 2.28 (8)°. The plane of the attached benzene ring is inclined to the plane of the quinoline system by 7.65 (7)°. The carboxylate group attached to the quinoline system is in an antiperiplanar conformation. There is a short intramolecular C—H⋯O contact involving the carbonyl group. In the crystal, molecules are linked via C—H⋯O hydrogen bonds, forming chains lying in the (1-10) plane.

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“…For the crystal structures of related quinoline derivatives, see: Pradeep et al (2014); Shrungesh Kumar et al (2015…”

Section: Related Literaturementioning

confidence: 99%

Crystal structure of ethyl 2-(3,5-difluorophenyl)quinoline-4-carboxylate

Sunitha¹,

Naveen

Manjunath³

et al. 2015

Acta Cryst E

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“…For pharmaceutical and pharmacological activities of quinolines, see: Beagley et al (2003). The title compound was synthesized in a continuation of our work on new quinolinebased therapeutic agents, see: Pradeep et al (2014 Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

“…Some of the quinoline-4-carboxylates were reported to possess potent 5HT 3 antagonizing activity and anti-emetic activity. In view of their broad spectrum of medicinal properties and in continuation of our work on new quinoline based therapeutic agents (Pradeep et al, 2014), the title compound was synthesized, and we report herein on its crystal structure.…”

Section: S1 Commentmentioning

confidence: 99%

Crystal structure of ethyl 6-bromo-2-[(E)-2-phenylethenyl]quinoline-4-carboxylate

et al. 2015

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In the title compound, C20H16BrNO2, the dihedral angle between the quinolone ring system mean plane (r.m.s. deviation = 0.018 Å) and the phenyl ring bridged by the ethynyl group, is 25.44 (14)°. There is an intramolecular C—H⋯O hydrogen bond forming an S(6) ring motif. In the crystal, molecules are linked via C—H⋯O hydrogen bonds forming chains propagating along the b-axis direction.

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“…For background to quinolines and their properties, see: Beagley et al (2003). For our work in this area, see: Pradeep et al (2014); Shrungesh Kumar et al (2015); Sunitha et al (2015). H atoms treated by a mixture of independent and constrained refinement Á max = 0.20 e Å À3 Á min = À0.28 e Å À3 Table 1 Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

Crystal structure of ethyl 2-(2,4,5-trimethoxyphenyl)quinoline-4-carboxylate

et al. 2015

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In the title compound, C21H21NO5, the dihedral angle between the quinoline ring system (r.m.s. deviation = 0.028 Å) and the trimethoxybenzene ring is 43.38 (5)°. The C atoms of the methoxy groups deviate from their attached benzene ring by −0.396 (2), −0.049 (2) and 0.192 (2) Å for the ortho-, meta- and para-substituents, respectively. The pendant ethyl chain is disordered over two orientations in a 0.527 (5):0.473 (5) ratio. A short intramolecular C—H⋯O contact closes an S(6) ring. In the crystal, inversion dimers linked by pairs of weak C—H⋯O interactions generate R 2 2(6) loops. The dimers are linked by further C—H⋯O interactions to generate [1-10] chains.

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Crystal structure ofcis-1-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)azepan-2-one

Cited by 4 publications

References 3 publications

Crystal structure of ethyl 2-(3,5-difluorophenyl)quinoline-4-carboxylate

Crystal structure of ethyl 2-(3,5-difluorophenyl)quinoline-4-carboxylate

Crystal structure of ethyl 6-bromo-2-[(E)-2-phenylethenyl]quinoline-4-carboxylate

Crystal structure of ethyl 2-(2,4,5-trimethoxyphenyl)quinoline-4-carboxylate

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