Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets

Chopra, Hitesh; Dey, Protity Shuvra; Das, Debashrita; Bhattacharya, Tanima; Shah, Muddaser; Mubin, Sidra; Maishu, Samka Peregrine; Akter, Rokeya; Rahman, Md. Habibur; Karthika, Chenmala; Murad, Waheed; Qusty, Naeem; Qusti, Safaa; Alshammari, Eida M.; Batiha, Gaber El‐Saber; Altalbawy, Farag M. A.; Albooq, Mona I. M.; Alamri, Badrieah M.

doi:10.3390/molecules26164998

Cited by 130 publications

(49 citation statements)

References 118 publications

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“…Turmeric, derived from the plant Curcuma longa, belonging to the Zingiberaceae family, is a gold-coloured spice and has been used traditionally as medicine for a variety of diseases [64,65]. Curcumin, turmeric's principal constituent, has several known neuroprotective actions.…”

Section: Curcuma Longamentioning

confidence: 99%

Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

Bhattacharya¹,

et al. 2022

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The strategies involved in the development of therapeutics for neurodegenerative disorders are very complex and challenging due to the existence of the blood-brain barrier (BBB), a closely spaced network of blood vessels and endothelial cells that functions to prevent the entry of unwanted substances in the brain. The emergence and advancement of nanotechnology shows favourable prospects to overcome this phenomenon. Engineered nanoparticles conjugated with drug moieties and imaging agents that have dimensions between 1 and 100 nm could potentially be used to ensure enhanced efficacy, cellular uptake, specific transport, and delivery of specific molecules to the brain, owing to their modified physico-chemical features. The conjugates of nanoparticles and medicinal plants, or their components known as nano phytomedicine, have been gaining significance lately in the development of novel neuro-therapeutics owing to their natural abundance, promising targeted delivery to the brain, and lesser potential to show adverse effects. In the present review, the promising application, and recent trends of combined nanotechnology and phytomedicine for the treatment of neurological disorders (ND) as compared to conventional therapies, have been addressed. Nanotechnology-based efforts performed in bioinformatics for early diagnosis as well as futuristic precision medicine in ND have also been discussed in the context of computational approach.

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Section: Curcuma Longamentioning

confidence: 99%

Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

Bhattacharya¹,

et al. 2022

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“…The CLEN complexes showed an increase in solubility by a factor of 1.4 × 10 6 times in comparison to 11 ng/ml (normal curcumin). Other authors have also documented literature citing the benefits of nano-curcumin ( Rahimi et al, 2016 ; Chopra et al, 2021 ).…”

Section: Nano-formulations and Green Synthesis: Strategies To Improve...mentioning

confidence: 99%

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

et al. 2022

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Endometrial cancer (EC) is the sixth most prevalent type of cancer among women. Kinases, enzymes mediating the transfer of adenosine triphosphate (ATP) in several signaling pathways, play a significant role in carcinogenesis and cancer cells’ survival and proliferation. Cyclin-dependent kinases (CDKs) are involved in EC pathogenesis; therefore, CDK inhibitors (CDKin) have a noteworthy therapeutic potential in this type of cancer, particularly in EC type 1. Natural compounds have been used for decades in the treatment of cancer serving as a source of anticancer bioactive molecules. Many phenolic and non-phenolic natural compounds covering flavonoids, stilbenoids, coumarins, biphenyl compounds, alkaloids, glycosides, terpenes, and terpenoids have shown moderate to high effectiveness against CDKin-mediated carcinogenic signaling pathways (PI3K, ERK1/2, Akt, ATM, mTOR, TP53). Pharmaceutical regimens based on two natural compounds, trabectedin and ixabepilone, have been investigated in humans showing short and midterm efficacy as second-line treatments in phase II clinical trials. The purpose of this review is twofold: the authors first provide an overview of the involvement of kinases and kinase inhibitors in the pathogenesis and treatment of EC and then discuss the existing evidence about natural products’ derived kinase inhibitors in the management of the disease and outline relevant future research.

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“…The therapeutic efficacy of curcumin-loaded nanogels in HeLa cell cultures was also examined in the paper. The nanogels were just as efficient as free CUR at inhibiting cancer cell proliferation [ 181 ].…”

Section: Various Nano Drug Delivery Systems For Curcuminmentioning

confidence: 99%

The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Tagde²,

et al. 2021

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Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.

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Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets

Cited by 130 publications

References 118 publications

Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

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