Current Advances on the Extraction and Identification of Bioactive Components of Sage (Salvia spp.)

Poulios, Efthymios; Giaginis, Constantinos; Vasios, Georgios K.

doi:10.2174/1389201020666190722130440

Cited by 18 publications

(14 citation statements)

References 52 publications

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“…However, minor or even only traces were found in nSMSs. Several other investigations [53][54][55][56] reported similar observations in Salvia. These studies did not clearly specify substitute delimitation owing to ambiguous fundamental in uential factors to determine substitutes in medicinal practice.…”

Section: Discussionsupporting

confidence: 74%

The Biology of Medicinal Resource Substitution in Salvia

Cui¹,

Chen²,

Bao-sheng³

et al. 2021

Preprint

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Background: The decrease of wild reserves and the sharp increase of market demand have led to resource substitution, but it is still not clear how to discover medicinal alternative resources. Here we reveal the biology of medicinal resource substitution in the case of Salvia.Methods: A hypothesis was put forward that phylogeny and ecology were the main factors which determined alternative species selection. Phylogenetic analysis was performed based on chloroplast genomes. Spatial climatic pattern was assessed through three mathematical models. Results: S. miltiorrhiza and alternative species were mainly located in Clade 3 in topology, and their growth environment was clustered into an independent group 3 inferred from Principal Component analysis. Correlation and Maxent major climate factor analyses showed that the ecological variations within each lineage were significantly smaller than the overall divergent between any two lineages. Mantel test reconfirmed the inalienability between phylogeny and ecology (P = 0.002). Only the species that are genetically and ecologically related to S. miltiorrhiza can form a cluster with it. Conclusion: Phylogenetic relationship and geographical climate work together to determine which species has the potential to be selected as substitutes. Other medicinal plants can learn from this biology towards developing alternative resources.

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Section: Discussionsupporting

confidence: 74%

The Biology of Medicinal Resource Substitution in Salvia

Cui¹,

Chen²,

Bao-sheng³

et al. 2021

Preprint

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“…The most common species, namely the Salvia officinalis L., represents an important medicinal and aromatic plant, with antioxidant, antimicrobial, anti-inflammatory and anticancer properties. Poulios et al [34] well summarized the current advances on the extraction and identification of bioactive components of sage; further, the same authors gave a current state-of-the-art on the antioxidant activity of sage (Salvia spp.) and its bioactive components [35].…”

Section: Introductionmentioning

confidence: 99%

Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria

Zaccardelli

Pane

Caputo

et al. 2020

Forests

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Sage species belong to the family of Labiatae/Lamiaceae and are diffused worldwide. More than 900 species of sage have been identified, and many of them are used for different purposes, i.e., culinary uses, traditional medicines and natural remedies and cosmetic applications. Another use of sage is the application of non-distilled sage extracts and essential oils to control phytopathogenic bacteria and fungi, for a sustainable, environmentally friendly agriculture. Biocidal propriety of non-distilled extracts and essential oils of sage are w documented. Antimicrobial effects of these sage extracts/essential oils depend on both sage species and bacteria and fungi species to control. In general, it is possible to choose some specific extracts/essential oils to control specific phytopathogenic bacteria or fungi. In this context, the use of nanotechnology techniques applied to essential oil from salvia could represent a future direction for improving the performance of eco-compatible and sustainable plant defence and represents a great challenge for the future.

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“…dant, antimicrobial, antimutagenic, anti-dementia, hypoglycemic, and hypolipidemic effects. Different chemical components have been found to be responsible for these activities [1][2][3].…”

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confidence: 99%

“…Sage species have been widely used for their antioxidant properties based on their phenolic compounds, and many different methods for the extraction and identification of these components have been reported [3]. The main polyphenolic compounds identified were rosmarinic acid, carnosic acid, salvianolic acid and its derivates (carnosol, rosmanol, epirosmanol, rosmadial, and methyl carnosate), tannins (salviatannin), essential oils (EOs) (including α-thujone, b-thujone, 1,8 cineole, and camphor), flavones, phenolic acids, phenylpropanoid glycosides, triterpenoids, and diterpenes, γ-tocopherol, α-tocopherol, carotenoids, gallic acid, 3-O-caffeoylquinic acid, 5-O-caffeoylquinic acid, caffeic acid, hesperetin, hispidulin, and genkwanin [9][10][11].…”

mentioning

confidence: 99%

Current State of the Art on the Antioxidant Activity of Sage (Salvia spp.) and Its Bioactive Components

2020

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Common sage (Salvia spp., with the most common species Salvia officinalis) is an important medicinal and aromatic plant due to its bioactive components, secondary products of its metabolism. These components are mainly phenolics, terpenoids, polyphenols, and flavonoids. Many studies have identified their important role in fighting oxidative stress in cells and organisms, together with their anticancer, antimicrobial, and anti-inflammatory role. There are many methods measuring the antioxidant activity of sage phenolic components, usually based on radical scavenging of free radical species, such as 2,2-diphenyl-1-picrylydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and determining the absorbance of the reduced product by a photometric assay. In addition, there are several in vitro and in vivo studies determining the protection of sage extracts in cells in culture or animals, respectively, after induction of oxidative stress. In this review, results from the currently available studies that unravel the significant role of sage bioactive compounds, as antioxidant compounds, and the variety of methods used have been critically analyzed and discussed.

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Current Advances on the Extraction and Identification of Bioactive Components of Sage (Salvia spp.)

Cited by 18 publications

References 52 publications

The Biology of Medicinal Resource Substitution in Salvia

The Biology of Medicinal Resource Substitution in Salvia

Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria

Current State of the Art on the Antioxidant Activity of Sage (Salvia spp.) and Its Bioactive Components

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