Current Prevalence and Characteristics of Dermatoses Associated with Human Immunodeficiency Virus Infection

Blanes, Mar; Belinchón, Isabel; Merino, Esperanza; Portilla, Joaquín; Sánchez‐Paya, José; Betlloch, Isabel

doi:10.1016/s1578-2190(10)70700-9

Cited by 19 publications

(21 citation statements)

References 11 publications

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“…9 Further studies showed tha the prevalence of seborrheic dermatitis in patients with HIV differs according to various authors. [10][11][12] It appears that the subtype of Malassezia sp. and level of CD4 + T cell are found to be risk factors of seborrheic dermatitis in patients of HIV/AIDS.…”

Section: Abstrakmentioning

confidence: 99%

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Panjaitan¹,

Pudjiati

Siswati

2014

JMedScie

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Human immunodefiiency virus (HIV) infection and aquired immunodeficiency syndrome (AIDS)cause a progressive depletion of CD4 + T cell populations accompanied by progressive impairment of cellular immunity and increasing susceptibility to opportunistic infections. Seborrheic dermatitis is one of the most common skin opportunistic infections on HIV/AIDS patients. Malassezia species is bilieved as the causative of seborrheic dermatitis. The aim of the study was to evaluate low CD4 + T cell counts as risk factor for Malassezia sp. infection in HIV/AIDS patients. This was an observational study with cross-sectional design conducted on HIV/AIDS patients who attended in Department of Dermatology and Venereology, Faculty of Medicine Universitas Gadjah Mada/ Dr Sardjito General Hospital, Yogyakarta and met the inclusion and exclusion criteria. Culture of Malassezia sp. was conducted in Department of Microbiology and classified as high (>100 CFU/ tape) and low (<100 CFU/tape) density colonies. CD4 Sci, Volume 46,No. 4, CFU/tape. Tidak ada hubungan bermakna adalah kadar sel T CD4 + dengan jumlah koloni Malassezia sp dalam penelitian ini (p=0,607; 95%CI=0,(4)(5)19; RP=0,452). Dapat disimpulkan, kadar sel T CD4 + yang rendah bukan merupakan faktor terjadinya infeksi Malassezia sp. pada penderita HIV/AIDS.

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Section: Abstrakmentioning

confidence: 99%

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Panjaitan¹,

Pudjiati

Siswati

2014

JMedScie

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“…For Soeprono et al, 85% of individuals with AIDS have SD, whereas Berger reported this figure as 36%, Goodman as 32% and Blanes et al as 31% of patients. [92][93][94][95][96][97][98][99][100][101][102] Malassezia spp. is also involved in the development of the disease.…”

Section: Seborrheic Dermatitis and Hivmentioning

confidence: 99%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment. . Keywords: Dermatitis; Dermatitis, seborrheic; Eczema Resumo: A dermatite seborreica é uma doença eritêmato-escamativa de caráter crônico-recidivante que acomete entre 1 e 3% da população geral dos Estados Unidos. Possui dois picos de incidência -o primeiro, durante os três primeiros meses de vida, e o segundo, a partir da puberdade, atingindo seu ápice entre os 40 e 60 anos de idade. Os indivíduos HIV positivos têm maior prevalência da doença, que apresenta maior intensidade e tendência à refratariedade ao tratamento. Doenças neurológicas e outras doenças crônicas também estão associadas ao desenvolvimento da dermatite seborreica. Como mecanismo fisiopatogênico, reconhece-se que o fungo Malassezia sp., presente na pele de indivíduos suscetíveis, leve a uma irritação não-imunogênica a partir da produção de metabólitos à base de áci-dos graxos insaturados deixados na superfície cutânea. Este artigo faz uma revisão da literatura sobre dermatite seborreica, com ênfase nos aspectos imunogenéticos, formas clínicas e tratamento.

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“…This high frequency of dermatological alterations was expected because previous studies performed by Blanes et al (2010) demonstrated that the prevalence of dermatoses in HIV/AIDS patients is approximately 98.3%. The most common conditions are xerosis, seborrheic dermatitis, distal subungual onychomycosis and viral warts.…”

Section: Discussionmentioning

confidence: 55%

Mucocutaneous mycoses in acquired immune deficiency syndrome (AIDS) patients hospitalised in a tertiary healthcare centre in the state of Amazonas-Brazil

Lindomar¹,

Diego²,

tia³

et al. 2012

Sci. Res. Essays

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Several studies have been performed in which the severity of human immunodeficiency virus (HIV)infection is correlated with skin manifestations. The state of Amazonas-Brazil has a high incidence of HIV infection (2008, 26/100.000 hab), and this state is located in the tropics, a climate that promotes the development of mycoses; however, few studies have been published in the literature that discuss the prevalence of superficial mucocutaneous fungal infections in acquired immune deficiency syndrome (AIDS) patients from this region. The objective of this study was to investigate clinical forms and etiologic agents of mucocutaneous mycoses in AIDS patients hospitalised in a tertiary healthcare centre in the state of Amazonas-Brazil. Specifically, the following factors were investigated: a) the frequency of patients with mucocutaneous mycoses, b) the clinical forms and c) the main etiological agents from the mucocutaneous mycoses. One hundred and seventy patients were submitted to a dermatological examination to search for predictive manifestations of mucocutaneous mycoses. Laboratory tests (micromorphological studies and culturing) were performed on the biological samples. The samples of skin scrapings, hair and nails and the oropharyngeal swabs were transported to the mycology laboratory of the FMT-HVD for micromorphological testing (slides, 40% KOH and cotton blue) and culture assays. Among the 170 patients, 116 presented clinical signs. Most of the patients were male (68%) between the ages of 31 and 40 years old (60%). Of the 137 sites suspected of mucocutaneous mycoses, only 52 were positive according to the laboratory tests. The most important clinical forms of mucocutaneous mycosis were oral candidiasis (58%) and onychomycosis (31%). Candida albicans and Trichophyton rubrum were the main causes of oral candidiasis and onychomycosis, respectively.

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Current Prevalence and Characteristics of Dermatoses Associated with Human Immunodeficiency Virus Infection

Cited by 19 publications

References 11 publications

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Dermatite seborreica

Mucocutaneous mycoses in acquired immune deficiency syndrome (AIDS) patients hospitalised in a tertiary healthcare centre in the state of Amazonas-Brazil

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