CUTANEOUS T-CELL LYMPHOMA IN TWO CAPTIVE TASMANIAN DEVILS (<i>SARCOPHILUS HARRISII</i>)

Scheelings, T. Franciscus; Dobson, Elizabeth; Hooper, Celia

doi:10.1638/2013-0217r.1

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…Spontaneous neoplasms in captive Tasmanian devils including squamous cell carcinoma of the lip and gingiva, dermal lymphosarcoma [3], trichoepithelioma, papilloma and keratoacanthoma [4] and a single devil with multiple unrelated tumours involving internal organs in combination with skin [5] have been recorded, suggestive of potential metastasis. Similar observations were made while reviewing Dasyurid archival material at the Australian Registry of Wildlife Health [6] and recently, two captive female devils with pruritus and dermatitis were diagnosed with cutaneous T-cell lymphoma [7]. None of the recorded neoplastic superficial lesions found in captive or wild Tasmanian devils appeared to mimic the firm, flattened centrally ulcerated soft tissue lesions of DFT1 affected Tasmanian devils [8].…”

Section: Introductionsupporting

confidence: 54%

ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)

et al. 2017

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Devil Facial Tumour 1 (DFT1) is one of two transmissible neoplasms of Tasmanian devils (Sarcophilus harrisii) predominantly affecting their facial regions. DFT1’s cellular origin is that of Schwann cell lineage where lesions are evident macroscopically late in the disease. Conversely, the pre-clinical timeframe from cellular transmission to appearance of DFT1 remains uncertain demonstrating the importance of an effective pre-clinical biomarker. We show that ERBB3, a marker expressed normally by the developing neural crest and Schwann cells, is immunohistohemically expressed by DFT1, therefore the potential of ERBB3 as a biomarker was explored. Under the hypothesis that serum ERBB3 levels may increase as DFT1 invades local and distant tissues our pilot study determined serum ERBB3 levels in normal Tasmanian devils and Tasmanian devils with DFT1. Compared to the baseline serum ERBB3 levels in unaffected Tasmanian devils, Tasmanian devils with DFT1 showed significant elevation of serum ERBB3 levels. Interestingly Tasmanian devils with cutaneous lymphoma (CL) also showed elevation of serum ERBB3 levels when compared to the baseline serum levels of Tasmanian devils without DFT1. Thus, elevated serum ERBB3 levels in otherwise healthy looking devils could predict possible DFT1 or CL in captive or wild devil populations and would have implications on the management, welfare and survival of Tasmanian devils. ERBB3 is also a therapeutic target and therefore the potential exists to consider modes of administration that may eradicate DFT1 from the wild.

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Section: Introductionsupporting

confidence: 54%

ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)

et al. 2017

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“…One additional case was seen in an animal that died of choking on a food item. Treatment was not attempted in these cases because of the poor prognosis, poor efficacy of treatment and the invasive nature of chemotherapy. Animals were monitored for health and quality of life and were euthanased when their condition deteriorated.…”

Section: Resultsmentioning

confidence: 99%

Causes of mortality and severe morbidity requiring euthanasia in captive Tasmanian devils (Sarcophilus harrisii) in Tasmania

Peck

Knowles³

et al. 2019

Aust Veterinary J

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Background Devil facial tumour disease (DFTD) is a contagious cancer causing marked population declines in wild Tasmanian devils. In response to this threat, a captive insurance population has been established. This study investigated causes of death in captive Tasmanian devils. Methods Clinical and laboratory records of captive Tasmanian devils held in seven Tasmanian captive facilities were analysed for cause of death or severe morbidity requiring euthanasia. Results Neoplasia was found to be the most common cause of mortality/severe morbidity, accounting for 27/63 of deaths. Cutaneous lymphoma was the most frequently observed tumour (10/27), at a higher incidence than previously reported. The most common cause of severe morbidity, following neoplasia, was leucoencephalomyelopathy, which caused severe, progressive hindlimb paresis and ataxia. Conclusion Neoplasia, specifically cutaneous lymphoma, and degenerative neurological conditions are the most frequent causes of death in captive Tasmanian devils in Tasmania. Further work to determine the aetiologies of these conditions, as well as effective treatments, would be valuable.

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“…CEL has been widely reported in dogs and cats . However, reports of CEL in other species are rare and include cows, hamsters, mice, and single reports in a rat, ferret, squirrel, coati, cuscus, chipmunk, zebrafish, hedgehog, Tasmanian devil, opossum, marsh rice rat, and alpaca . There are currently no reports of CEL in NHPs.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous epitheliotropic lymphoma in a baboon (Papiospp.): A case report and a brief literature review

Carias

DeLorenzo

Owston

et al. 2019

J of Medical Primatology

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Cutaneous epitheliotropic lymphoma (CEL) is a rare neoplasm of T-cell lymphocytes with a tropism for epidermis and adnexal components. 1-4 CEL, or epidermotropic lymphoma, 5,6 was first reported in humans as a condition called mycosis fungoides (MF). 7 CEL is extremely rare in non-canid species 4 ; there have been no reports of CEL in non-human primates (NHPs). We present a case of CEL in a 9-year-old baboon and present a brief review of CEL in veterinary literature. | C A S E REP ORTThe 9-year-old female baboon (Papio spp.) was maintained at the Southwest National Primate Research Center and presented with raised pruritic lesions on the right forearm skin. The animal was treated with cephalexin (538.5 mg, PO BID, Lupin Pharmaceuticals) for 1 week. The lesion persisted, and following the results of a skin punch biopsy, the animal was euthanized 2 months later. All animal care and procedures were approved by the Texas Biomedical Research Institute Institutional Animal Care and Use Committee.A complete necropsy was performed; except for the skin and axillary lymph node (enlarged), the rest of the organs were AbstractCutaneous epitheliotropic lymphoma (CEL) has not been reported in non-human primates. We report the first case of CEL in a 9-year-old baboon. The phenotype of the neoplastic cells in this baboon is similar to CEL in humans (CD3+, CD4+, CD8−) and different from dogs (CD3+, CD4−, CD8+).

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CUTANEOUS T-CELL LYMPHOMA IN TWO CAPTIVE TASMANIAN DEVILS (SARCOPHILUS HARRISII)

Cited by 13 publications

References 16 publications

ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)

ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)

Causes of mortality and severe morbidity requiring euthanasia in captive Tasmanian devils (Sarcophilus harrisii) in Tasmania

Cutaneous epitheliotropic lymphoma in a baboon (Papiospp.): A case report and a brief literature review

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