Decline of Serum Human Chorionic Gonadotropin and Spontaneous Complete Abortion: Defining the Normal Curve

Barnhart, Kurt T.; Sammel, Mary D.; Chung, Karine; Zhou, Lan; Hummel, Amy; Guo, Wensheng

doi:10.1097/01.aog.0000142712.80407.fd

Cited by 108 publications

(80 citation statements)

References 13 publications

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“…Barnhart et al (2004) and Fong et al (2005) revealed that there is a relationship between early pregnancy outcome and β-hCG levels. 27,28 Forat et al (2007) examined the relationship between long-term pregnancy outcome and hCG.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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-hCG (beta-human chorionic gonadotrophin) is a pregnancy-associated molecule produced by implanted blastocysts and trophoblastic cells. β-hCG as one of the earliest embryonal signals may be a major regulator in the paracrine embryo-endometrial communication.1,2 β-hCG measurement in serum is a method used routinely for pregnancy test after the IVF (invitro fertilization) procedure.3 Serial measurements of β-hCG is a marker which is also used for distinguishing pregnancies running their course from ectopic pregnancy or spontaneous pregnancy losses in early pregnancy. [4][5][6] In increasing number of recent studies, it has become a current issue that β-hCG levels in early A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study is to investigate the parameters of female, male and cycles that could affect post-ART (assisted reproductive techniques)-pregnancy initial beta hCG value. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this retrospective study, data of 3056 individuals who had become pregnant with IVF/ICSI at a private IVF center and between 2006 and 2016 and whose pregnancies continued for over 12 weeks were evaluated. Initial beta-hCG values of these pregnancies were compared with parameters of mothers, fathers and cycles. R Re es su ul lt ts s: : It was seen in this study that there is a negative correlation between the initial beta-hCG values of pregnancies achieved by assisted reproductive techniques and mothers BMI values and a positive correlation between those beta-hCG values and the embryo transfer day. C Co on nc cl lu us si io on n: : The data obtained in the study need to be supported with larger series in the future. It is also thought that these data may contribute to the literature which tries to achieve a β -hCG cut-off value in the determination of pregnancy outcome. Ya zış ma Ad re si/Cor res pon den ce:

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Section: Discussionmentioning

confidence: 99%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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“…When using an HCG ratio (HCG at 48 h/ HCG at 0 h) cut-off of 0.87, the sensitivity and specificity for the prediction of failing Pregnancy of unknown locations were 92.7 and 96.7%, respectively (Condous., 2006.). A rate of decline in serum HCG 21% could define spontaneous resolution of the pregnancy of unknown locations (Barnhart et al, 2004.). Serial quantitative HCG, however, could not meet the rapid diagnosis of EPs.…”

Section: Prospective Analysismentioning

confidence: 99%

Clinical Application of One-Step Diagnosis for Ectopic Pregnancy by HCG Ratio: Hemoperitoneum Versus Venous Serum

Wang¹,

Cheng²,

Wan³

2011

Ectopic Pregnancy - Modern Diagnosis and Management

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“…Barhart et al (11) studied the hCG serum levels in patients diagnosed with PUL and the final outcome of viable intrauterine pregnancy. In their study, the median hCG level at the time of application was reported as 388 and the average increase in the hCG levels was reported as 50% for the first day and 124% for the second day.…”

Section: Serum Hcg Levels In Early Viable Intrauterine Pregnancymentioning

confidence: 99%

“…If the level of the first serum hCG level is high, it would decline more rapidly. The time required for hCG levels to clear following dilation and curettage is generally between 12 and 16 days (11). When a spontaneously resolving pregnancy has serum hCG levels declining to undetectable levels without surgical or medical intervention, this is defined as a failed PUL.…”

Section: Serum Hcg Levels In Spontaneous Abortionmentioning

confidence: 99%

Pregnancy of unknown location

Boyraz

Bozdağ

2013

J Turkish German Gynecol Assoc

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Pregnancy of unknown location (PUL) is defined as the situation when the pregnancy test is positive but there are no signs of intrauterine pregnancy or an extrauterine pregnancy via transvaginal ultrasonography. It is not always possible to determine the location of the pregnancy in cases of PUL. The reported rate of PUL among women attending early pregnancy units varies between 5 and 42% in the literature and the frequency of PUL incidents has increased with the increase in the number of early pregnancy units. The management of PUL seems to be highly crucial in obstetrics clinics. Therefore, in the current review, issues identified from the literature related to pregnancy of unknown location, potential tools for prediction and algorithms will be discussed. (J Turkish-German Gynecol Assoc 2013; 14: 104-8)

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Decline of Serum Human Chorionic Gonadotropin and Spontaneous Complete Abortion: Defining the Normal Curve

Abstract: The rate of hCG decrease in spontaneous abortions is described by a quadratic profile, with a faster decline in hCG value with higher presentation levels. A rate of decline less than 21% at 2 days or 60% at 7 days suggests retained trophoblasts or an ectopic pregnancy.

Cited by 108 publications

References 13 publications

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Clinical Application of One-Step Diagnosis for Ectopic Pregnancy by HCG Ratio: Hemoperitoneum Versus Venous Serum

Pregnancy of unknown location

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