Dendrimer nanotechnology for enhanced formulation and controlled delivery of resveratrol

Abstract

In spite of its wide and beneficial pharmacological potential, resveratrol lags behind other compounds because of its comparatively less impressive pharmacokinetic profile. Resveratrol has very low oral bioavailability and, from a formulation perspective, it has low solubility in water, which leads to its poor absorption upon oral administration. Apart from low aqueous solubility, resveratrol has poor metabolic stability and instability at high pH, and is photosensitive. The pharmacokinetic and formulation-related limitations of resveratrol can be controlled by entrapping the small resveratrol molecule inside highly water-soluble poly(amidoamine) dendrimer nanostructures, which provide spherical architecture and polyvalency at the nanoscale level, thus leading to novel features. Dendrimer architecture is used to entrap resveratrol for enhancement of its solubility and stability in aqueous solution; they can be engineered to control pharmacokinetics and targeting for oral, mucosal, transdermal, or parenteral administration. Dendrimers have the potential to work as excipients with multifunctional capability by enhancing solubility, dissolution, stability, permeability, multiple drug/cosmetic entrapment, controlled delivery, bioavailability, and efficacy of drugs.

Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen

“…Dendrimers have been successfully shown to improve transdermal drug delivery, but most of the reports available are on PAMAM dendrimers (Chauhan et al, 2003, Cheng, 2007Chauhan, 2015). Some of the widely used dendrimers including PAMAM dendrimers have been reported to be toxic in many studies (Jevprasesphant et The reports on the use of peptide dendrimers for transdermal delivery are limited to our research group.…”

Comparison study of the effect of alkyl-modified and unmodified PAMAM and PPI dendrimers on solubility and antitumor activity of crocetin

“…In our previous studies, different chain lengths of bromoalkylcarboxylates were conjugated with different percentage of primary amines of PAMAMs and PPIs. The results showed that 30% substitution of primary amines by 10-bromodecanoic group resulted in higher gene transfection efficiency and lower cytotoxicity compared to other formulations (Ayatollahi et al 2015, Hashemi et al 2013, 2015). In the current study, we modified the surface layer of PAMAM G4 and PPI G4 by 30% surface primary amines grafting with 10-bromodecanoic acid and explored their potential as solubility enhancers and drug delivery carriers.…”

“…Such modifications may alter the host-guest interactions, and thereby increase the solubility. In our previous studies, it was shown that alkylation of PAMAM and PPI could reduce their cytotoxicity and enhance gene delivery efficiency (Ayatollahi et al 2015, Hashemi et al 2013, 2015. Accordingly, the aim of this study was to evaluate the performance of alkyl-modified PPI G4 and PAMAM G4 derivatives as enhancers of solubility and antitumor activity of crocetin.…”

“…Dendrimers can improve the solubility of drugs possibly through hydrophobic, hydrogen bonds and/or electrostatic interactions. Several studies have reported the efficiency of dendrimers in solubility enhancement of various drugs and poor soluble compounds (Beezer et al 2003, Chauhan 2015, Wang et al 2013. Furthermore, dendrimers can be engineered and conjugated with different functional motifs such as targeting molecules (Majoros et al 2006).…”

A Review on Nanosponges a Review on Nanosponges: A Boon to Targeted Drug Delivery for Anticancer Drug

“…Regardless of the extensive research, the information on the drug plasma level still stays dim [59]. A few activities have been going onto overcome the limitation of resveratrol using several methods such as nanoparticle technology, niosomes, and nanovesicles [60][61][62][63][64][65][66]. Researcher utilized NSs to enhance the solvency, soundness, and skin penetrability of resveratrol [67].…”