Dentigerous Cyst and Ameloblastoma of the Jaws

Barrett, A.W.; Sneddon, K.; Tighe, John V.; Gulati, Aakshay; Newman, Laurence; Collyer, Jeremy; Norris, Paul; Coombes, Darryl; Shelley, Michael; Bisase, Brian; Liebmann, Rachael

doi:10.1177/1066896916666319

Cited by 30 publications

(16 citation statements)

References 21 publications

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“…Both are characterized by a structure similar to other nonneoplastic cystic lesions and also share clinical and radiological features with many of them. Very often UA and OKC mimic a dentigerous cyst (DC), and consequently, it is necessary to include them in the differential diagnosis [ 6 – 9 ]. To understand the similarities and differences among them that could be useful for diagnosis and therapeutic purposes, it is important to study the cellular and extracellular elements that take part on the physiopathological mechanisms implicated in their origin and growth; therefore, the aim of this study was to evaluate and compare Ki67, CD138, and the molecular RANK, RANKL, and OPG triad expression on the lining epithelium and stroma of UA, OKC, and DC.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts

et al. 2018

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Background and Objective Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, CD138, and the molecular triad RANK, RANKL, and OPG in odontogenic keratocysts (OKC), unicystic ameloblastomas (UA), and dentigerous cysts (DC). Methods Immunohistochemistry for Ki-67, CD138, RANK, RANKL, and OPG was performed in 58 odontogenic cystic lesions (22 OKC, 17 DC, and 19 UA). Results A higher expression of Ki-67 was identified in OKC as compared to UA (p < 0.0001). UA exhibited a greater loss of CD138 expression versus OKCs (p > 0.0034). RANKL was expressed higher in the epithelium (p = 0.0002) and in the stroma (p = 0.0004) of UA. DC had a lower expression of these markers. Conclusion Higher RANKL expression together with the reduction on CD138 expression in UA could be linked to a greater invasive and destructive potential, while the increased proliferation rate observed in OKC could be related to its continuous intrabony growth. The expansion of DC does not seem to be related to such factors, justifying the different therapeutic approaches proposed for each of these entities.

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Section: Introductionmentioning

confidence: 99%

A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts

et al. 2018

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“…Tkaczuk et al from their 15-year-experience with the jaw cysts consider jaw cysts occurring in children to be rarely symptomatic (8). Barrett et al suggested that sometimes ameloblastomas were misdiagnosed as dentigerous cysts (9). Saccucci M. et al in their study report have described conservative treatment for 9-year-old child affected by radicular cyst (6).…”

Section: Discussionmentioning

confidence: 99%

The Radicular Cyst in a Child: Case Report

2021

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The most commonly occurring odontogenic cysts of the jaws are radicular cysts. Causes of jaw cysts are different, numerous and depend on the type of cyst. The basic precondition for the occurrence of a cystic lesion is the previous presence of epithelial tissue at the site of future development of the cystic formation. Radicular cysts are one of the most common odontogenic cysts and arise from epithelial so-called Malassez - these residues in the periodontal tissue, as a consequence of inflammation of the pulp. They can occur at any age, and are equally prevalent in both sexes. The aim of this paper is to present the clinical symptoms and treatment of a radicular cyst in a 12-year-old child. The treatment of radicular cysts in most cases is surgical. The possibilities for such treatment and the choice of surgical method depend on the size of the cyst, its location, and the pathological formation. The present article reported a case of a 12-year-old male with the chief complaint of pain on the right lower back tooth region. The radiographic examination revealed the presence of a well-defined radiolucency surrounded by a corticated border between mandibular central incisive. The case was managed by complete enucleation under local anesthesia without extraction of any teeth. We chose enucleation (cystectomy) as a surgical procedure as the method of choice, because postoperative complications are the rarest, and the best healing is also provided. Аfter one month of surgery treatment, complete wound healing was recorded at the clinical control at the Department for oral surgery.

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“…12 The region in which both lesions are most common is at the jaw, the diagnosis depends largely on the histopathological evaluation and it is in this part where there can be controversy and confusion, according to Ackermann 13 , Philipsen 14 , Robinson 15 , they mention that histologically the degeneration of solid/multicystic ameloblastomas (SMA) should be considered since it is usually extensive and sometimes gives the appearance of a cyst identical to the Dentigerous Cyst; Likewise, it has been studied that the presence of a unicystic Ameloblastoma (UA) lacks a mural or intraluminal component (mainly the luminal or simple variant) and this variant of Ameloblastoma can also give a misinterpretation and considered a simple cyst. [13][14][15][16] For all the above, a representative case of both pathological entities is presented, treated in the Maxillofacial Surgery service of "La Raza" Medical Center.…”

Section: Introductionmentioning

confidence: 99%

Synchronous presentation of two dentigerous cysts and ameloblastoma: Eight-years follow-up

Giselle

Sergio

Daniel

et al. 2021

Medico Research Chronicles

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Dentigerous cysts are benign lesions mainly related to the crown of a tooth, early diagnosis is essential (which is almost always done radiographically and sometimes clinically) these not usually causing symptoms unless these are large and generate compression on nerve structures, the possibility of transformation or the evolution of these lesions to ameloblastomas has been described in the literature, possibly due to cellular and protein changes, among others, which are still under study. Ameloblastomas, on the other hand, are aggressive benign tumors and their possible formation from a dentigerous cyst has been described. It is important to have a good histopathological diagnosis since sometimes similarities can be observed and these can generate controversy or confusion between them. The present clinical case is representative because it involves both lesions in the same site, the importance lies in the fact that conservative treatment was provided through enucleation and curettage of the lesions performed at the Maxillofacial Surgery at "La Raza" National Medical Center. And then the patient was kept under control, showing clinical and radiographic results at eight years of follow-up, without recurrences, with adequate evolution and a good prognosis.

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Dentigerous Cyst and Ameloblastoma of the Jaws

Abstract: The entire clinical team must ensure that a histopathological diagnosis of DC is consistent with the clinicoradiological scenario, particularly in younger patients.

Cited by 30 publications

References 21 publications

A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts

A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts

The Radicular Cyst in a Child: Case Report

Synchronous presentation of two dentigerous cysts and ameloblastoma: Eight-years follow-up

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