Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats

Jensen, Dalan R.; Tone, J. N.; Sørensen, Rita; Bozek, Stephen A.

doi:10.1016/0300-483x(82)90063-4

Cited by 24 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gossypol accumulates mainly in the liver (Lordelo et al., 2005), in most of the mammals including fish (Roehm et al., 1967), lambs (Kim et al., 1996), rats (Sharma et al., 1966; Chen et al., 1987) and broilers (Gamboa et al., 2001a). Feeding diets containing gossypol was also reported to increase liver size in broilers (Henry et al., 2001b), lambs (Kandylis et al., 1998) and rats (Jensen et al., 1982). No significant effect on the liver weight was noted during the present experiment which confirmed the low gossypol level of the CSM used.…”

Section: Discussionmentioning

confidence: 99%

Influence of pre‐press solvent‐extracted cottonseed meal supplemented with exogenous enzyme and digestible lysine on performance, digestibility, carcass and immunity responses of broiler chickens

Mushtaq

Sarwar

Ahmad

et al. 2009

Animal Physiology Nutrition

View full text Add to dashboard Cite

The response of broiler chickens to two levels of endo-1,4-beta xylanase (EC 3.2.1.8) and endo-1,3-beta glucanase (EC 3.2.1.6) combination (with and without), three levels of digestible lysine (0.8%, 0.9% and 1.0% with the applicability of ideal protein concept) and two levels of cottonseed meal (CSM; 20% and 30%) were evaluated in 2 x 3 x 2 factorial arrangement. A total of 2448 male Hubbard broiler chicks were fed on practical vegetable-based mash diets having 2750 kcal metabolizable energy (ME) per kg and 18.5% crude protein (CP) from the age of day 1 to 42. The supplemental enzyme had minimum 1100 units of endo-1,4-beta xylanase and 100 units of endo-1,3-beta glucanase/kg of finished diet. The addition of CSM at 30% resulted in increasing arginine to lysine ratio. A decrease in dressing and breast percentages were observed by the addition of 30% CSM. The digestible lysine at 1.0% decreased the body weight (BW) gain and lowered the mortality during day 1 to 21 whereas the BW gain and feed:gain ratio were unaffected among the three digestible lysine levels during day 1 to 42. The antibody titres against Newcastle and infectious bursal disease viruses were improved with the increasing levels of digestible lysine. The enzyme supplementation improved the apparent ME and digestibility coefficient of nitrogen when it was used with 30% CSM. No effect of enzyme, lysine, CSM or their interactions was observed on serum iron, gizzard and liver weights or abdominal fat percentage. The results showed that increasing digestible lysine improved the antibody titre but did not improve the growth performance and carcass characteristics; supplemental enzyme failed to show any improvement in performance of birds fed on CSM-based diets.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of pre‐press solvent‐extracted cottonseed meal supplemented with exogenous enzyme and digestible lysine on performance, digestibility, carcass and immunity responses of broiler chickens

Mushtaq

Sarwar

Ahmad

et al. 2009

Animal Physiology Nutrition

View full text Add to dashboard Cite

show abstract

“…The biological half-life of 14C-containing materials in the rat body was 48 h without and 23 h with added iron . When male rats were treated orally with gossypol at a dose level of 40mg kg -1 body weight day-l for 2,4, or 8 weeks, free and bound gossypol was found in all tissues analysed (Jensen et at., 1982). Based on jlg of total gossypol (free and bound)/g wet tissue, the spleen showed the highest tissue concentration, followed by heart, kidneys, liver, lungs, and testes.…”

Section: Disposition Excretion and Metabolismmentioning

confidence: 99%

Toxicological effects of gossypol

Nomeir¹,

Abou‐Donia²

1985

Male Fertility and Its Regulation

View full text Add to dashboard Cite

“…This suggests that the antioxidant system of largemouth bass is damaged because of certain constituents of plant proteins, and which could be partly responsible for the changes in hepatic morphology in this study. Previous studies have shown that anti-nutrition factors (gossypol) in cottonseed protein accumulate in the liver tissue of fish and cause inflammation (Jensen et al, 1982;Lee et al, 2002;Soares et al, 2012). However, adding yeast culture to feed can reduce gossypol induced liver inflammation of Ussuri catfish (Pseudobagrus ussuriensis) (Bu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Yeast culture supplementation alters the performance and health status of juvenile largemouth bass ( Micropterus salmoides ) fed a high‐plant protein diet

Zhong

Wei

et al. 2021

Aquacult Nutr

View full text Add to dashboard Cite

Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats

Cited by 24 publications

References 19 publications

Influence of pre‐press solvent‐extracted cottonseed meal supplemented with exogenous enzyme and digestible lysine on performance, digestibility, carcass and immunity responses of broiler chickens

Influence of pre‐press solvent‐extracted cottonseed meal supplemented with exogenous enzyme and digestible lysine on performance, digestibility, carcass and immunity responses of broiler chickens

Toxicological effects of gossypol

Yeast culture supplementation alters the performance and health status of juvenile largemouth bass ( Micropterus salmoides ) fed a high‐plant protein diet

Contact Info

Product

Resources

About