Depression and Cardiovascular Diseases

Ромасенко, Л. В.

doi:10.14412/2074-2711-2009-48

Cited by 3 publications

(7 citation statements)

References 8 publications

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“…Benzodiazepines are usually chosen as such a standard in CTs in patients with NDs and, in particular, ADs. Therefore, four CTs with the use of bromdihydrochlorphenylbenzodiazepine, diazepam, clonazepam, and tofisopam as the control therapy were conducted [58][59][60].…”

Section: Comparison Of the Tp Abs To S100 Efficacy And Safety With Benzodiazepinesmentioning

confidence: 99%

“…In this open-label CT, 60 patients with AjD (n = 35) or SD (n = 25) and cardiovascular diseases (CVDs) (coronary heart disease (CHD), arterial hypertension (AH) grades II-III, postmyocarditis cardiosclerosis, dyshormonal myocardial dystrophy with cardiac arrhythmias, ventricular and supraventricular extrasystoles, atrial fibrillation, and heart defects) were randomly prescribed to receive TP Abs to S100 6 tablets/day (n = 30) or clonazepam 0.5-1 mg/day (n = 20) as an anxiolytic treatment in addition to standard therapy of CVD for 28 days after signing an ICF [59]. The control group (n = 10) was not administered any antianxiety medication.…”

Section: Open-label Comparative Randomized Ct Of Tp Abs To S100 and Clonazepammentioning

confidence: 99%

“…Two CTs that compared TP Abs to S100 with clonazepam and tofisopam in patients with CVD were described above [59,60]. The results showed equal efficacy of TP Abs to S100 and tofisopam in CVD patients.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

“…More than 2000 patients with GAD (F41.1), SD (F45), adjustment disorders (AjDs) (F43.2), neurasthenia (F48.0), and anxiety accompanying somatic diseases (cardiovascular and gastrointestinal disorders) took part in phase III, IV, and postmarketing clinical trials (CTs) of TP Abs to S100, including two double-blind placebo-controlled randomized CTs and nine open-label comparative randomized CTs [55][56][57]. TP Abs to S100 were shown to be as effective as clonazepam 0.5-1 mg/day, bromdihydrochlorphenylbenzodiazepine 1.5 mg/day (for 7 days), and tofisopam 100 mg/day but causing less adverse events (AEs) [58][59][60].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Technologically Processed Highly Diluted Antibodies to S100 Protein in the Treatment of Neurotic Disorders: The Review

Khacheva¹,

Khakimova²,

Glazunov³

et al. 2021

Anxiety Disorders - The New Achievements

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Neurotic disorders (NDs) are among the most common mental diseases leading to a decrease in the quality of life, lack of socialization, and increased mortality. The diagnosis and treatment of all types of NDs are challenging. In the light of the ongoing search for an effective and safe therapeutic strategy influencing certain aspects of ND pathogenesis, technologically processed highly diluted antibodies to S100 protein (TP Abs to S100) seem to be a promising treatment option for patients with NDs. TP Abs to S100 possess stress-protective, anxiolytic, antidepressant, antiamnestic, and neuroprotective activities. In the current review, we describe the mechanisms of action and pharmacological effects of TP Abs to S100 demonstrated in nonclinical (preclinical) and clinical studies. Based on the data, we tried to evaluate the future prospects of the TP Abs to S100 as the drug of choice for ND treatment.

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Section: Comparison Of the Tp Abs To S100 Efficacy And Safety With Benzodiazepinesmentioning

confidence: 99%

Section: Open-label Comparative Randomized Ct Of Tp Abs To S100 and Clonazepammentioning

confidence: 99%

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Technologically Processed Highly Diluted Antibodies to S100 Protein in the Treatment of Neurotic Disorders: The Review

Khacheva¹,

Khakimova²,

Glazunov³

et al. 2021

Anxiety Disorders - The New Achievements

View full text Add to dashboard Cite

show abstract

“…Другой аспект взаимодействия психического и соматического -увеличение тяжести течения и прогноза соматической патологии на фоне ТДР [6]. Риск летальности после перенесённого инфаркта миокарда или приступа нестабильной стенокардии у пациентов с депрессией увеличивается в 6,7 раза [7].…”

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The use of psychometric methods for the diagnosis of anxiety and depressive disorders in patients with a general somatic profile

Dubatova

Владимировна²,

Voyakina³

et al. 2019

Kazan Med J

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Aim. To identify and compare the level of anxiety and depression in therapeutic patients with somatic pathology, establish the structure of the gender distribution of anxiety and depressive disorders. Methods. The study involved 126 people: 74 (58.73%) women and 52 (41.27%) men aged 21–59 years. 59 patients had diseases of the respiratory system (chronic bronchitis in the acute stage with an asthmatic component), 67 patients with cardiovascular diseases (40 subjects with coronary heart disease, 27 subjects with arterial hypertension). In 11 patients with coronary artery disease and 13 patients with hypertension, type I thyrotoxicosis was diagnosed. Clinical psychopathological, psychometric, psychological and statistical methods were used in the study. Psychometric tests were used: the Depression Scale of the Center for Epidemiological Research; Hospital Anxiety and Depression Scale and Taylor Anxiety Disorder Scale adapted by T.A. Nemchinova and V.G. Norakidze, adapted standardized multivariate questionnaire for personality research. Results. According to the severity of anxiety and depressive disorders, patients were divided into the groups: group 1 with severe level, group 2 with a moderate (subclinical) level, and group 3 with mild (not exceeding the norm) anxiety and depressive disorders. Severe and moderate disorders are most characteristic for the pathology of cardiovascular system. In coronary artery disease and arterial hypertension, abnormal (severe and moderate) anxiety and depressive disorders were observed in 24/29 (82.76%) and 20/22 (90.9%) patients, respectively. In patients with abnormal anxiety and depressive disorders, the number of women prevailed over men in the subgroup with hypertension (80% versus 20%, p=0.025) as well as in combination of hypertension with type 1 thyrotoxicosis (85.7% versus 14.3%, р=0.029). Conclusion. In patients, severe and moderate anxiety and depressive disorders are associated with the development of the pathology of cardiovascular system: coronary heart disease and arterial hypertension.

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Si̇bi̇rya Araştirmalarinin Unutulan Öncüsü: Gerhard Friedrich Müller

Akbaba

2022

Genel Türk Tarihi Araştırmaları Dergisi

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Müller, a scientist of German origin, was born into a bourgeois, educator family. The joint studies of German-Russian scientists during the reign of Peter the Great, especially the fact that German scientists went to Russia, also influenced Müller. After Müller went to Russia as a graduate historian, he carried out almost all of his scientific studies there. He took important positions at the Petersburg Academy of Sciences, which he entered shortly after and served for many years. Also, the expeditions that started during the reign of Peter the Great enabled Müller to discover his main field of work. The Siberian studies of Daniel Gottlieb Messerschmidt (1685-1735) influenced Müller. Again in 1725, the First Kamchatka Expedition organized by Vitus Bering, who was commissioned by Peter I, to find the land and sea connections between Asia and America, also increased Müller's interest in Siberia. Thus, Müller applied for the Second Kamchatka Expedition in 1733 and was accepted. In this trip, he collected many materials and described the people of Siberia. After this trip, which lasted about ten years, he created the most important works in the field of Siberian history. The most important of these is Istorii Sibiri, which consists of four volumes. In this work, the war with Yermak, the construction of Siberian cities, including the construction of Siberia from ancient times to XVIII. Century has been told. He applied the research methods of the West in Russia and became one of the founders of modern Russian historiography. After Müller's work, the first ethnographic museum and ethnography chair in Russia were established. Norman theory again caused great controversy in Russia after his conference. He also served in other duties besides historiography, He rose to the position of rector during the Yekaterina II reign. The life and scientific personality of Müller, the pioneer of Siberian studies, has been studied especially by German and Russian historians. Few monographs exist in the rest of Europe. In Turkey, however, a monograph has not been conducted yet. Müller influenced the methods of studies on Siberian Turks in Russia. Because Müller collected information about the material and spiritual lives of the Turkish and Finno-Ugric peoples and tried to explain their historical, geographical, cultural and religious characteristics. In addition, he investigated the factors affecting the socio-cultural, political and economic articulation of the Turkic peoples in Siberia with the Russian Empire. In this respect, it is important to know Müller's scientific personality and works in Turkey. In this study, Müller's autobiography was used as the most crucial source of his scientific career. Apart from this, biographies written in the 20th century during the Union of Soviet Socialist Republics hold an essential place. However, in these biographies, Müller's bourgeois origins are emphasized and there is prejudice. Severe criticism of the Norman theory also influenced the formation of harsh expressions in the biographies. In this regard, it has to be carefully studied. Evaluations to the contrary are seen in the biographies written by German scientists. In these biographies, it is stated that Müller was the founder of the science of ethnography. It is also seen that Russian sources are not used enough. In this respect, biographies were carefully evaluated in the study. Unverifiable information is not included. Thus, it is aimed to reveal Müller's life, scientific activities and contributions.

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Depression and Cardiovascular Diseases

Cited by 3 publications

References 8 publications

Technologically Processed Highly Diluted Antibodies to S100 Protein in the Treatment of Neurotic Disorders: The Review

Technologically Processed Highly Diluted Antibodies to S100 Protein in the Treatment of Neurotic Disorders: The Review

The use of psychometric methods for the diagnosis of anxiety and depressive disorders in patients with a general somatic profile

Si̇bi̇rya Araştirmalarinin Unutulan Öncüsü: Gerhard Friedrich Müller

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