Derivate von vicinalem Trimethoxybenzol. 2. Mitt.: Amide und Hydrazide der Trimethylgallussäure

Abstract

Ausgangsstoff : 2,O g L-Ephedrin-hydrochlorid (0,Ol Mol). Herstellung wie unter V angegeben. Farblose Kristalle, Loslichkeit wie bei IV. Ausbeute: 1,5 g = 69%. Schmp.L (BthanollWasser) : 64--65O. Schmp.9 (&hanol/Wasser) : 65-66O. Rf = 9.91.

Synthesis of Some Glycidic Hydrazides and Amides as Potential Psychotropic Agents and Anticholinergic Agents

“…Consequently, this reaction was applied to the synthesis of a,P-epoxy esters which, when exposed to hydrazinolysis and/or aminolysis, yield potentially active hydrazides and amides. a,P-Epoxy amides and hydrazides have been of interest to the authors and others ( 5 ) as potential therapeutic agents. In appropriately substituted glycidic hydrazides, the presence of the epoxide function may .affect the distribution of compounds possessing monoamine oxidase-inhibiting pharmacophores.…”