Design and Computational Evaluation of a Pediatric MagLev Rotary Blood Pump

Tompkins, Landon H; Gellman, Barry; Morello, Gino; Prina, Steven R; Roussel, Thomas J.; Kopechek, Jonathan A.; Petit, Priscilla C; Slaughter, Mark S.; Koenig, Steven C.; Dasse, Kurt A.

doi:10.1097/mat.0000000000001323

Cited by 9 publications

(10 citation statements)

References 32 publications

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“…The NeoMate System ( Fig 1A ) design criteria included demonstrating the ability to achieve flow rates of 0.5–3.5 L/min at pressures up to 150 mmHg with pump rotational speeds ranging from 500–6000 RPM. Initial design of the NeoMate pump impeller and preliminary CFD analysis based on these criteria have been previously reported [ 13 ]. Since this initial development, the impeller and pump designs have been iteratively improved, resulting in the first functioning shaft-less pump prototypes.…”

Section: Methodsmentioning

confidence: 99%

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

et al. 2022

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Inspired Therapeutics (Merritt Island, FL) is developing a mechanical circulatory support (MCS) system designed as a single driver with interchangeable, extracorporeal, magnetically levitated pumps. The NeoMate system design features an integrated centrifugal rotary pump, motor, and controller that will be housed in a single compact unit. Conceptually, the primary innovation of this technology will be the combination of disposable, low-cost pumps for use with a single, multi-functional, universal controller to support multiple pediatric cardiopulmonary indications. In response to the paucity of clinically available pediatric devices, Inspired Therapeutics is specifically targeting the underserved neonate and infant heart failure (HF) patient population first. In this article, we present the development of the prototype Inspired Therapeutics NeoMate System for pediatric left ventricular assist device (LVAD) support, and feasibility testing in static mock flow loops (H-Q curves), dynamic mock flow loops (hemodynamics), and in an acute healthy ovine model (hemodynamics and clinical applicability). The resultant hydrodynamic and hemodynamic data demonstrated the ability of this prototype pediatric LVAD and universal controller to function over a range of rotary pump speeds (500–6000 RPM), to provide pump flow rates of up to 2.6 L/min, and to volume unload the left ventricle in acute animals. Key engineering challenges observed and proposed solutions for the next design iteration are also presented.

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Section: Methodsmentioning

confidence: 99%

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

et al. 2022

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“…Shear stress is considered one of the major factors causing hemolysis. Many researchers have used shear stress distribution to explain the hemolytic performance of bloodcontacting devices (8,13). Eq.…”

Section: Shear Stress Distributionmentioning

confidence: 99%

“…Tompkins et al designed a magnetically levitated rotary blood pump for pediatric use. They used the CFD method to optimize the fluid structure and calculated and analyzed the pump's hydraulic performance (8). Thamsen et al combined the CFD method with particle image velocimetry to study the flow field of the HeartMate 3 (9).…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic evaluation and in vitro hemolysis evaluation of a novel centrifugal pump for extracorporeal membrane oxygenation

Fu¹,

Liu²,

Wu³

et al. 2021

Ann Transl Med

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Background: The STM CP-24 I centrifugal pump is a newly developed centrifugal pump for extracorporeal membrane oxygenation equipment. This study aimed to combine hydraulic experiments, hemodynamic numerical simulations, and standard in vitro hemolysis experiments to investigate the comprehensive performance of this centrifugal pump. Methods:In vitro experiments were first done to obtain the pressure-flow data of the centrifugal pump in its working range to evaluate its hydraulic performance. Next, the commonly used clinical working points were selected as boundary conditions, and a computational fluid dynamics method was applied to evaluate its hemodynamic performance. The blood pressure distribution, blood flow fields, and high-wall-shear-stress zones in the centrifugal pump were determined as indicators for hemodynamic evaluation. Finally, standard in vitro hemolysis experiments were performed to test the blood compatibility of this centrifugal pump (n=3 blood samples). In addition, its blood compatibility was evaluated in the form of the normalized index of hemolysis (NIH).Results: The pressure-flow curve of the centrifugal pump showed that the head pressure and flow of the centrifugal pump showed a mostly linear relationship within the whole working range. When the rotation speed of the centrifugal pump was 5,500 rpm, it achieved a hydraulic performance of 550 mmHg head pressure and 8 L/min output flow, which could meet the clinical needs of extracorporeal membrane oxygenation. Analysis of computational fluid dynamics data indicated that the centrifugal pump had excellent hemodynamic performance: even distribution of blood pressure in the pump, no blood flow stagnation zone or dead zone in the overall flow field, and secondary flows in the gap between the rotor and the volute that significantly reduced the volume of the low-blood-flow zone close to the impeller. There was no obvious high-shear-stress zone on the surface of the volute or the impeller, which will effectively reduce the risk of thrombosis. In vitro hemolysis experiments indicated that the centrifugal pump had excellent blood biocompatibility, with a NIH =0.0125±0.0022 g/100 L. Conclusions:The STM CP-24 I centrifugal pump has excellent hydraulic performance, a reasonable design of the hemodynamic structure of the blood pump, and excellent blood compatibility. Therefore, it can meet clinical needs.

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“…The turbulent flow also contains high NPSS 21,22 . In addition, centrifugal blood pumps are often equipped with secondary flow passages to avoid internal blood stagnation 23,24 . The presence of secondary flow passages leads to a large number of secondary flows, and the collision/mixing of these secondary flows with main flow can also lead to high NPSSS 19,21 .…”

Section: Introductionmentioning

confidence: 99%

“…21,22 In addition, centrifugal blood pumps are often equipped with secondary flow passages to avoid internal blood stagnation. 23,24 The presence of secondary flow passages leads to a large number of secondary flows, and the collision/mixing of these secondary flows with main flow can also lead to high NPSSS. 19,21 The level of NPSS in the blood pump usually exceeds 100 Pa, when blood moves through the blood pump, it will be subjected to NPSS.…”

Section: Introductionmentioning

confidence: 99%

Impact of volute design features on hemodynamic performance and hemocompatibility of centrifugal blood pumps used in ECMO

Wang

et al. 2022

Artificial Organs

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Background The centrifugal blood pump volute has a significant impact on its hemodynamic performance hemocompatibility. Previous studies about the effect of volute design features on the performance of blood pumps are relatively few. Methods In the present study, the computational fluid dynamics (CFD) method was utilized to evaluate the impact of volute design factors, including spiral start position, volute tongue radius, inlet height, size, shape and diffuser pipe angle on the hemolysis index and thrombogenic potential of the centrifugal blood pump. Results Correlation analysis shows that flow losses affect the hemocompatibility of the blood pump by influencing shear stress and residence time. The closer the spiral start position of the volute, the better the hydraulic performance and hemocompatibility of the blood pump. Too large or too small volute inlet heights can worsen hydraulic performance and hemolysis, and higher volute inlet height can increase the thrombogenic potential. Small volute sizes exacerbate hemolysis and large volute sizes increase the thrombogenic risk, but volute size does not affect hydraulic performance. When the diffuser pipe is tangent to the base circle of the volute, the best hydraulic performance and hemolysis performance of the blood pump is achieved, but the thrombogenic potential is increased. The trapezoid volute has poor hydraulic performance and hemocompatibility. The round volute has the best hydraulic and hemolysis performance, but the thrombogenic potential is higher than that of the rectangle volute. Conclusion This study found that the hemolysis index shows a significant correlation with spiral start position, volute size, and diffuser pipe angle. Thrombogenic potential exhibits a good correlation with all the studied volute design features. The flow losses affect the hemocompatibility of the blood pump by influencing shear stress and residence time. The finding of this study can be used to guide the optimization of blood pump for improving the hemodynamic performance and hemocompatibility.

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Design and Computational Evaluation of a Pediatric MagLev Rotary Blood Pump

Abstract: Supplemental Digital Content is available in the text.

Cited by 9 publications

References 32 publications

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

Hemodynamic evaluation and in vitro hemolysis evaluation of a novel centrifugal pump for extracorporeal membrane oxygenation

Impact of volute design features on hemodynamic performance and hemocompatibility of centrifugal blood pumps used in ECMO

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