Design and Evaluation of Rapidly Disintegrating Tablets of Racecadotril with Enhanced in-vitro Dissolution Achieved by Solid Dispersion Technique

Abstract

The objectives of present investigations were to enhance dissolution rate of irbesartan by using chitosan and chitosan chlorhydrate and optimize an effective concentrations of both.Cocrystals of irbesartan (IB) were prepared by solvent change technique.Chitosan solution was prepared by soaking chitosan and chitosan chlorhydrate in glacial acetic acid. A weighed amount of drug was dispersed in chitosan solution by stirring. The dispersion was added to sodium citrate solution to precipitate 0 chitosan on drug crystals. The precipitate obtained was filtered through Whatmann No. 1 filter paper using vacuum filtration unit and dried at 45 C for 24 h. The prepared cocrystals were characterized in terms of saturation solubility, drug content, infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), in vitro dissolution studies and stability studies. The considerable improvement in the dissolution rate of drug from optimized co-crystal formulation was attributed to the decreased drug crystallinity, altered surface morphology and reduction in particle size. The 0.2% chitosan and 0.4% chitosan chlorhydrate were found to be optimized concentrations for enhancement of dissolution rate of irbesartan. The technique is scalable and may prove valuable in manufacturing process in future for enhancement of dissolution of poorly water soluble drugs.

Solubility Enhancement of Lornoxicam by Crystal Engineering

“…An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. After equilibrium, the solution was filtered through Whatman filter paper (#41) and the concentration of drug was determined spectrophotometrically at λ max 378 nm [21] .…”

Formula Optimization of Orally Disintegrating Tablet Containing Meloxicam Nanoparticles

“…Previous research studied the use of wet granulation to produce meloxicam ODT (Kulkarni et al, 2010), the use of sublimation (Elbary et al, 2012) and solid dispersion (Singhvi et al, 2013) methods to increase the dissolution rate of meloxicam ODT, and the use of ion exchange and complexation with cyclodextrin to mask the taste of meloxicam ODT (Samprasit et al, 2013). To the authors knowledge, literature search found no study that explores the effects of different superdisintegrants on the characteristics of nano-meloxicam ODT.…”