Design of Biologically Active Surfaces Based on Functionalized Polysulfones by Electrospinning

Abstract

The development of a new generation of electrospun polymeric materials designed to accomplish multi-performance in a bioinspired integrated system represents the main goal of the present research. Polysulfones promise to become such nanosized fibrous structures with attractive properties associated with biomedical applications by the development of a new "construct". Therefore, the homogeneous solutions of the functionalized polysulfones with quaternary ammonium groups (PSFQ) dissolved in various solvents were processed by electrospinning to create polymeric scaffolds that can modulate cellular behavior. Additionally, the antibacterial activity of PSFQ fibers against Gram-negative and Gram-positive bacteria has indicated the potential of these scaffolds for biomedical use.

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

“…Their low mechanical stability is also not adequate to support cells, and their products are thus insufficient for the regeneration of tissue. Moreover, the methods for obtaining such materials are limited due to the low resistance of natural polymers to changes in process parameters, such as high temperatures [ 25 , 50 , 51 , 57 , 59 , 64 , 76 , 86 ].Synthetic polymers, such as poly(ethylene glycol) (PEG) [ 87 , 88 ], polycaprolactone (PCL) [ 89 , 90 ], polylactic acid (PLA) [ 87 , 91 , 92 ], polyurethane [ 93 , 94 ], poly(glycolic acid) (PGA) [ 87 , 95 ], polyethersulfone (PES) [ 96 , 97 , 98 , 99 ], and polysulfone [ 100 , 101 ], are more diverse and promising. Some of these materials have been approved by the FDA for clinical human use [ 49 , 51 , 57 , 102 , 103 , 104 , 105 ].…”