Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Zou, Chen-Yu; Li, Qianjin; Hu, Junmei; Song, Yuting; Zhang, Qingyi; Nie, Rong; Li‐Ling, Jesse; Xie, Huiqi

doi:10.1016/j.mtbio.2022.100468

Cited by 24 publications

(12 citation statements)

References 189 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hemostats used to fill the wound should be of appropriate mechanical strength to prevent deformation due to external stresses from the surrounding tissues Figures S8 and S9 show that GPZ had higher deformation resistance than Gel, GP, and GZ.…”

Section: Resultsmentioning

confidence: 99%

“…The hemostats used to fill the wound should be of appropriate mechanical strength to prevent deformation due to external stresses from the surrounding tissues. 37 Figures S8 and S9 show that GPZ had higher deformation resistance than Gel, GP, and GZ. Absorbing water after compression of the sponge, the GPZ sponge can quickly return to its original shape, as shown in Figure 2C.…”

Section: Physical Properties Of the Gpz Spongementioning

confidence: 99%

See 1 more Smart Citation

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Du,

Bai,

Lang

et al. 2023

Biomacromolecules

View full text Add to dashboard Cite

Developing a hemostatic sponge that can effectively control bleeding from visceral injuries while guiding in situ tissue regeneration in incompressible wounds remains a challenge. Most of the existing hemostatic sponges degrade slowly, are relatively single-functioning, and cannot cope with complex environments. Herein, a biodegradable rapidly hemostatic sponge (GPZ) was created by dual-dynamic-bond cross-linking among Zn2+, protocatechualdehyde (PA)-containing catechol and aldehyde groups, and gelatin. GPZ had a uniformly distributed interconnected pore structure with excellent fluid absorption. It could effectively absorb the oozing blood and increase the blood concentration while stimulating platelet activation and accelerating blood coagulation. Compared to commercial hemostats, GPZ treatment significantly accelerated hemostasis in the rat liver defect model (∼0.33 min, ≥50% reduction in the hemostatic time) and in the rabbit liver defect model (∼1.02 min, ≥60% reduction in the hemostatic time). Additionally, GPZ had excellent antibacterial and antioxidant properties that effectively protected the wound from infection and excessive inflammation. In the liver regeneration model, GPZ significantly increased the rate of hepatic tissue repair and promoted rapid functional recovery without complications and adverse reactions. Overall, we designed a simple and effective biodegradable rapid hemostatic sponge with good clinical translational potential for treating lethal incompressible bleeding and promoting wound healing.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Physical Properties Of the Gpz Spongementioning

confidence: 99%

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Du,

Bai,

Lang

et al. 2023

Biomacromolecules

View full text Add to dashboard Cite

show abstract

“…[ 11 ] Among them, powdered hemostats exhibit outstanding features, including portability, ready‐to‐use for non‐trained persons, the ability to be directly sprayed over a large defect area irrespective of the exact bleeding site, and are suitable for irregular and non‐compressible bleeding wounds. [ 3a,12 ] Upon applying to the wound bed, the porous structure of hemostatic powders can rapidly absorb blood and concentrate coagulation factors to facilitate blood clotting. However, existing commercially available hemostatic powders such as zeolite‐based QuickClot, chitosan‐based Celox, and starch‐based Arista usually display relatively weak mechanical strength, lack of enough tissue adhesion, and/or low biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control

Zhang

Xian

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, and do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable and adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH2), and tetra‐armed poly(ethylene glycol) succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, the macroporous CM can rapidly absorb the interfacial liquids, and meanwhile, the hydrated GAP turns into hydrogel (crosslinking between Tetra‐PEG‐SS and CM/Tetra‐PEG‐NH2) with stable and robust adhesion to the wet tissue though covalent bonding. The in vitro and in vivo results suggest that the GAP with optimized formulation exhibits strong tissue adhesive, high burst pressure, and enhanced blood clotting ability, as well as excellent biocompatibility and on‐demand removal properties. A significantly improved hemostatic efficacy is demonstrated in the rat liver, spleen, and femoral artery injury models compared to that of the CM, commercial fibrin glue, and Yunnan Baiyao (YB). The GAP can also halt the severe bleeding from pig visceral organs. Overall, the proposed GAP has many advantages including good biocompatibility, rapid and effective hemostasis, low cost, and ease of use, making it as a promising hemostat for lethal non‐compressible hemorrhage control.

show abstract

“…Various hemostatic agents (e.g., powder and hydrogels) have been widely designed for the wound hemorrhage. − In some cases, bleeding after tissue puncture with syringe needles could cause psychological fear in patients, especially for children. Further, it increases the risk of local or systemic complications (e.g., subcutaneous bruises, swelling, nerve damage, and uncontrolled bleeding) in patients suffering from hemophilia, Von Willebrand disease, vitamin K deficiency, rat poisoning, warfarin poisoning, and disseminated intravascular coagulation. , Recently, a self-sealing hemostatic needle coated with catechol-conjugated chitosan has been reported for antibleeding after tissue puncture via solid-to-gel phase transition of catechol-functionalized chitosan. , However, the preparation process of hemostatic needles either involved complex modification of polymers or an oxidative preincubation process of 3 days to achieve hemostatic functions. Sodium alginate and CaCl 2 have been also used to decorate hypodermic needles, which also exhibit hemostasis during tissue puncture. , Nevertheless, the coating detached from the needle surface only serves as a physical barrier to prevent bleeding without affording antibacterial activity, while infection occurs more often at punctured sites and obstructs the healing of the punctured tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Further, it increases the risk of local or systemic complications (e.g., subcutaneous bruises, swelling, nerve damage, and uncontrolled bleeding) in patients suffering from hemophilia, Von Willebrand disease, vitamin K deficiency, rat poisoning, warfarin poisoning, and disseminated intravascular coagulation. 6,7 Recently, a self-sealing hemostatic needle coated with catechol-conjugated chitosan has been reported for antibleeding after tissue puncture via solid-to-gel phase transition of catechol-functionalized chitosan. 8,9 However, the preparation process of hemostatic needles either involved complex modification of polymers or an oxidative preincubation process of 3 days to achieve hemostatic functions.…”

Section: Introductionmentioning

confidence: 99%

Biologically Derived Nanoarchitectonic Coatings for the Engineering of Hemostatic Needles

Zhang,

Liu,

Geng

et al. 2023

Biomacromolecules

View full text Add to dashboard Cite

Bleeding after venipuncture could cause blood loss, hematoma, bruising, hemorrhagic shock, and even death. Herein, a hemostatic needle with antibacterial property is developed via coating of biologically derived carboxymethyl chitosan (CMCS) and Cirsium setosum extract (CsE). The rapid transition from films of the coatings to hydrogels under a wet environment provides an opportunity to detach the coatings from needles and subsequently seal the punctured site. The hydrogels do not significantly influence the healing process of the puncture site. After hemostasis, the coatings on hemostatic needles degrade in 72 h without inducing a systemic immune response. The composition of CMCS can inhibit bacteria of Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus by destroying the membrane of bacteria. The hemostatic needle with good hemostasis efficacy, antibacterial property, and safety is promising for the prevention of bleeding-associated complications in practical applications.

show abstract

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Cited by 24 publications

References 189 publications

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control

Biologically Derived Nanoarchitectonic Coatings for the Engineering of Hemostatic Needles

Contact Info

Product

Resources

About