Design of polymeric nanoparticles for the encapsulation of monoacylglycerol

Chiewpattanakul, Paramaporn; Covis, Rudy; Vanderesse, Régis; Thanomsub, Benjamas; Marie, Emmanuelle; Durand, Alain

doi:10.1007/s00396-010-2216-8

Cited by 14 publications

(11 citation statements)

References 31 publications

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“…4,5 The rich rheological response of WLM has led to their exploitation in various industrial processes such as fracturing fluids in oil fields, cooling fluids, liquid dish-washing detergents and personal care products such as shampoos and body soaps. [6][7][8][9][10][11][12] Similarly, a rich rheological behaviour has been observed in solutions of associative polymers or hydrophobically modified polymers (HMPs), which are water-soluble polymers with hydrophobic pendant groups [13][14][15][16][17][18][19][20][21] (often referred to as 'stickers'). Interest in HMP primarily started for applications in oil recovery and rheological control of paints and coatings [22][23][24][25] but their interest now extends to the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Associative networks of cholesterol-modified dextran with short and long micelles

et al. 2011

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The strong associative behaviour between cholesterol-modified dextran (CMD) and short and long polyoxyethylene cholesteryl ether (ChEO 10 ) micelles were investigated using rheology and small-angle neutron scattering (SANS). In solutions of short rod-like micelles (ChEO 10 alone), the addition of 5.0 wt% CMD induced a remarkable transition from a Newtonian system to a highly solid-like viscoelastic network, with an increase in zero-shear viscosity of over 5 orders of magnitude. The frequency sweeps at ChEO 10 concentrations above 2.5 wt% were fitted to a Maxwell model with 3 elements and, quite remarkably, fell onto a single master curve, while no network was formed at 2.5 wt% micelles. Viscoelastic solutions of wormlike micelles (WLMs) were obtained by adding the co-surfactant triethylene glycol monododecyl ether (C 12 EO 3 ) to ChEO 10 solutions at a constant ChEO 10 /C 12 EO 3 ratio of 5/1. The introduction of CMD into the WLM solutions induced a transition to a more liquidlike behaviour (G 00 /G 0 increased), however both moduli increased by one order of magnitude. At the lowest ChEO 10 concentration (2.5%), the solid-like behaviour was lost. Overall, a comparable rheological response was obtained for the WLM and the short rods with CMD, however the WLM/ CMD behaviour suggested a wider spectrum of relaxation processes, longer relaxation times and higher plateau moduli. SANS data from the polymer/micelles mixtures displayed a strong structural peak and were remarkably identical for both ChEO 10 /CMD and ChEO 10 /C 12 EO 3 /CMD systems, suggesting a very similar type of network structure, independently of the initial size of the micelles. Overall, all the results taken together show a very high affinity between the polymer and the micelles and suggest a breakup of the WLM induced by CMD. The resulting network is constituted by polymeric chains connected by micellar aggregates through hydrophobic interactions between the micellar cholesterol cores and the pendent cholesterol moieties of the polymer.

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Section: Introductionmentioning

confidence: 99%

Associative networks of cholesterol-modified dextran with short and long micelles

et al. 2011

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“…Cell apoptosis is a critical form of cell death that occurs devoid of persuade the swelling of cell, although the morphological and biochemical properties like membrane blebbing and inter-nucleosomal DNA cleavage are known to be illustrated the apoptosis 2 . The most important way of programmed cell death apoptosis plays a key role in directive of tissue generation and homeostasis, consequently the initiating of programmed cell death is a rising approach for prevention and treatment of cancer 3 . The heart of modern technology is dealing the innovation of medicine with potential to treat the cervical cancer from least toxicity to natural cells 4 .…”

Section: Introductionmentioning

confidence: 99%

Development of glycolipid biosurfactant for inducing apoptosis in HeLa cells

et al. 2016

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A novel glycolipid biosurfactant produced from Staphylococcus aureus was used to induce the apoptosis in HeLa cells. The production of biosurfactant was optimized using different carbon and nitrogen sources. Sucrose and sodium nitrate are found to be best substrate among the tested carbon and nitrogen sources that showed high growth, yield and emulsification activity. The produced biosurfactant was characterized using GC-MS analysis and the results showed the presence of Palmitoleic acid, Oleic acid, 1,2-benzenedicarboxylic acid and Linoleic acid confirming that the biosurfactant was glycerol derived in nature. FTIR results confirmed the presence of sugar residues and α-pyranose form of glucose residues and 1 H NMR analysis showed the presence of glycerol moiety at 3.5 ppm for -CH2 group and 3.8 ppm for -CH group. We found that this glycolipid was induced significant reduction in HeLa cells viability in a dose dependent manner. It was further confirmed through AO/EB and DCFH-DA staining that reveals the glycolipids were actively involved in induction of apoptosis on HeLa cells. Moreover, after 24 hr exposure of glycolipids induce S phase and G2/M cell cycle arrest in HeLa cells.

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“…Due to their lipidic nature and the consequent easy decomposition at higher temperatures, 1-MAGs belong to substances not suitable for being processed using the above mentioned methods, and mild processes are required. Chiewpattanakul et al [17] proposed dextran-covered nanoparticles encapsulating 1-MAG of myristic acid (C14:0) which were produced by emulsion/solvent evaporation method and by nanoprecipitation.…”

Section: Introductionmentioning

confidence: 99%

“…Nanoprecipitation needs specific, sometimes unique conditions of solvent temperature and concentration to provide satisfactory results in terms of particle size and distribution [17].…”

Section: Introductionmentioning

confidence: 99%