Design of transdermal patch of ketoprofen by full factorial design for treatment of rheumatoid arthritis

Rao, Monica Rp; Sonavane, Vijay; Kulkarni, Sayali; Magar, Mayuri K.; Abhishek, Zope; Karanjkar, Pooja B.

doi:10.22270/jddt.v9i2.2549

Cited by 12 publications

(13 citation statements)

References 16 publications

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“…Rao et al have prepared a transdermal patch of ketoprofen and its optimization was done using 32 factorial design method, which is in accordance with our proceeding [ 38 ]. In the present study, 32 factorial design was used to evaluate the effect of independent variables (T50% and T80%) of film (dependent variable).…”

Section: Resultsmentioning

confidence: 99%

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Fabrication and Characterization of Chitosan—Tamarind Seed Polysaccharide Composite Film for Transdermal Delivery of Protein/Peptide

et al. 2021

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Transdermal drug delivery is used to deliver a drug by eliminating the first-pass metabolism, which increases the bioavailability of the drug. The present study aims to formulate the chitosan–tamarind seed polysaccharide composite films and evaluate for the delivery of protein/peptide molecules. Nine formulations were prepared and evaluated by using different parameters, such as physical appearance, folding endurance, thickness of film, surface pH, weight variation, drug content, surface morphology, percentage moisture intake and uptake, drug release kinetics, and drug permeability. The film weight variance was observed between 0.34 ± 0.002 to 0.47 ± 0.003 g. The drug level of the prepared films was found to be between 96 ± 1.21 and 98 ± 1.33μg. Their intake of moisture ranged between 2.83 ± 0.002 and 3.76 ± 0.001 (%). The moisture absorption of the films ranged from 5.33 ± 0.22 to 10.02 ± 0.61 (%). SEM images revealed a smooth film surface, while minor cracks were found in the film after permeation tests. During the first 4 days, drug release was between 13.75 ± 1.64% and 22.54 ± 1.34% and from day 5 to day 6, it was between 72.67 ± 2.13% and 78.33 ± 3.13%. Drug permeation during the first 4 days was 15.78 ± 1.23 %. Drug permeation (%) during the first 4 days was between 15.78 ± 1.23 and 22.49 ± 1.29 and from day 5 to day 6, it was between 71.49 ± 3.21 and 77.93 ± 3.20.

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Section: Resultsmentioning

confidence: 99%

“…Rao et al have prepared a transdermal patch of ketoprofen and its optimization was done using 32 factorial design method, which is in accordance with our proceeding [38].…”

Section: Factorial Designmentioning

confidence: 99%

Fabrication and Characterization of Chitosan—Tamarind Seed Polysaccharide Composite Film for Transdermal Delivery of Protein/Peptide

et al. 2021

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“…8 and 9. XRD diffractograms revealed that pure gliclazide showed distinctive peaks in 2θ=14., 17.3, 20.1, 25.8 and 28.4 which indicate the crystalline nature of pure Gliclazide [22]. The XRD patterns of pure drug, polymers, and physical mixture of drug and polymers are represented in Figs.…”

Section: X-ray Powder Diffractometrymentioning

confidence: 97%

“…The length of each strip is measured and variation in length is measured by determining percent constriction. 0% constriction is equivalent to 100% flatness [22].…”

Section: Flatnessmentioning

confidence: 99%

The Pharmaceutical Application of Sulfoxy Amine Chitosan in Design, Development and Evaluation of Transdermal Drug Delivery of Gliclazide

Jadhav

Pallavi

Vyankatrao

et al. 2020

JPRI

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Objective: The aim & objectives of this research work was to explore applicability of our previously synthesized sulfoxy amine chitosan in design, development and evaluation of transdermal drug delivery of Gliclazide. Methods: To determine the interaction between excipients used and to find out the nature of drug in the formulation, Fourier transforms infra-red spectroscopy (FTIR) and Differential Scanning Colorimetry (DSC) studies were performed. Gliclazide containing transdermal patch were formulated with help of Sulfoxy Amine Chitosan, HPMC, Penetration enhancer Dimethyl Sulfoxide and Glycerine by using solvent casting method.9 formulations prepared by using 32 full factorial designs the effect of formulation variable was studied on % Moisture Content, Folding endurance, % Cumulative drug release at 12 hrs.Formulated transdermal patches were evaluated for various parameters. Results: FTIR & DSC suggest study no drug & polymers interaction .All the prepared transdermal patches were found to be faint yellow in colored, flexible, uniform, smooth, and transparent. The weight of the transdermal patches for different type of formulations ranged between 12.00 ± 0.6 mg & 14.2 ± 0.52 mg. The thickness of the patches varied from 0.171 ± 0.0035 mm to 0.182 ± 0.0026 mm. The moisture content & water vapour transmission rate in the patches ranged from 2.33 to 4.55% & from 0.002246 to 0.003597 mg.cm/cm2 24hrs.XRD diffractogram revealed pure Gliclazide exhibited characteristic high-intensity diffraction peaks & optimized formulation showed three peaks in 2θ= 20.6 28.7 and 38.95 with very weak intensities. Optimized batch F7 showed maximum drug release 98.41%. The folding endurance was lies in between 301 and 359. Optimization study was successfully conducted using 32 factorial designs. Conclusion: We concluded that transdermal patches Gliclazide of was successfully formulated with synthesized Sulfoxy Amine Chitosan & evaluated.

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“…The frictional forces in a loose powder can be measured by the angle of repose. It is defined as the maximum angle possible between the surface of the pile of powder and the horizontal plane [26].…”

Section: Evaluation Of Pre-compression Parametersmentioning

confidence: 99%

Design, Development and Evaluation of Mouth Dissolving Tablets of Tofacitinib Citrate

RAYKAR

Velraj

2022

Int J App Pharm

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Objective: This study aims to Formulate Mouth Dissolving Tablets (MDTs) of Tofacitinib Citrate with the increase in bioavailability and patient compliance. Methods: Mouth Dissolving Tablets (MDTs) of Tofacitinib Citrate were developed by full factorial design at 32levelsand prepared by direct compression method using super integrants like sodium starch glycolate, Ludiflash. The tablets were compressed into compacts on a 10 station tablet machine. The bulk drug was characterised by determining, MP, Solubility, pH and FTIR spectra. Results: The weight variation, hardness and diameter, thickness, friability, drug content, wetting time, in vitro disintegration time and in vitro dissolution studies, and stability study, tablet thickness, weight variation and drug content post compression parameters remained consistent and reproducible. All the formulations showed, almost 100 percent of drug release within 75 min. Formulations F1, F2 and F3 were prepared with 5 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F1<F2<F3. Formulations F4, F5 and F6 were prepared with 10 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F4<F5<F6. Formulations F7, F8 and F9 were prepared with 15 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F7<F8<F9. Conclusion: It is concluded that the amount of superdisintegrants decreases disintegration time of tablets, decreases wetting time, increases the cumulative % drug release causes better absorption.

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Design of transdermal patch of ketoprofen by full factorial design for treatment of rheumatoid arthritis

Cited by 12 publications

References 16 publications

Fabrication and Characterization of Chitosan—Tamarind Seed Polysaccharide Composite Film for Transdermal Delivery of Protein/Peptide

Fabrication and Characterization of Chitosan—Tamarind Seed Polysaccharide Composite Film for Transdermal Delivery of Protein/Peptide

The Pharmaceutical Application of Sulfoxy Amine Chitosan in Design, Development and Evaluation of Transdermal Drug Delivery of Gliclazide

Design, Development and Evaluation of Mouth Dissolving Tablets of Tofacitinib Citrate

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