Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

Zeng, Ziyuan; Zhu, Miaomiao; Chen, Long; Zhang, Yingying; Lü, Tao; Deng, Yankang; Ma, Wenjing; Xu, Jianhua; Huang, Chaobo; Xiong, Ranhua

doi:10.1016/j.compositesb.2022.110313

Cited by 75 publications

(33 citation statements)

References 126 publications

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“…At 30 dpw, 2GC1DP6 displayed a remarkable 93.4% WHP ( p < 0.05) in contrast to 50% and 58% WHP for the control and sodium-alginate-treated wounds. Hydrogels are regarded as highly competitive wound-healing materials to date because of their crucial properties desirable for wound healing such as hemostasis, antibiosis, regenerative, and anti-inflammatory . Interestingly, efficient promotion and acceleration of healing were demonstrated by GC/DP hydrogels even after their indirect application to wounds as compared to a relatively smaller molecule, sodium alginate.…”

Section: Resultsmentioning

confidence: 99%

“…Hydrogels are regarded as highly competitive wound-healing materials to date because of their crucial properties desirable for wound healing such as hemostasis, antibiosis, regenerative, and anti-inflammatory. 61 Interestingly, efficient promotion and acceleration of healing were demonstrated by GC/DP hydrogels even after their indirect application to wounds as compared to a relatively smaller molecule, sodium alginate. The remarkable treatment of the wounds through immersion in a relatively nontoxic hydrogel concentration only signifies that the presence of a GC/DP Schiff base hydrogel provided an ideal environment to promote and accelerate healing as compared to wounds immersed only in the normal water system (control�without any agent) and in the water system containing sodium alginate.…”

Section: Chemical Structurementioning

confidence: 99%

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Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties

Balitaan

Luo

et al. 2023

ACS Appl. Bio Mater.

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The high prevalence of acquiring skin wounds, along with the emergence of antibiotic-resistant strains that lead to infections, impose a threat to the physical, mental, and socioeconomic health of society. Among the wide array of wound dressings developed, hydrogels are regarded as a biomimetic soft matter of choice owing to their ability to provide a moist environment ideal for healing. Herein, neutral glycol chitosan (GC) was cross-linked via imine bonds with varying concentrations of dibenzaldehyde-terminated polyethylene glycol (DP) to give glycol chitosan/dibenzaldehyde-terminated polyethylene glycol hydrogels (GC/DP). These dynamic Schiff base linkages (absorption peak at 1638 cm–1) within the hydrogel structure endowed their ability to recover from damage as characterized by high-low strain exposure in continuous step strain rheology. Along with their good injectability and biodegradability, the hydrogels exhibited remarkable inhibition against E. coli, P. aeruginosa, and S. aureus. GC/DP hydrogels demonstrated high LC50 values in vivo using zebrafish embryos as a model system due to their relative biocompatibility and a remarkable 93.4 ± 0.88% wound contraction at 30-dpw against 49.1 ± 3.40% of the control. To the best of our knowledge, this is the first study that developed injectable glycol chitosan/dibenzaldehyde-terminated polyethylene glycol self-healing hydrogels for application in wound healing with intrinsic bacteriostatic properties against the three bacteria.

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Section: Resultsmentioning

confidence: 99%

Section: Chemical Structurementioning

confidence: 99%

Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties

Balitaan

Luo

et al. 2023

ACS Appl. Bio Mater.

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“…Hydrogels are mostly fabricated by physical or chemical cross-linking of various hydrophilic polymers. Depending on the source of materials, hydrogels can be divided into natural polymer-based hydrogels, synthetic polymer-based hydrogels, biomimetic polymer-based hydrogels, and hybrid hydrogels [ 15 , 16 ]. The property of hydrogels is also affected by different cross-linking strategies.…”

Section: Hydrogels and Nanomaterials For Wound Healingmentioning

confidence: 99%

Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing

et al. 2022

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Wound dressing is an important tool for wound management. Designing wound dressings by combining various novel materials and drugs to optimize the peri-wound environment and promote wound healing is a novel concept. Hydrogels feature good ductility, high water content, and favorable oxygen transport, which makes them become some of the most promising materials for wound dressings. In addition, nanomaterials exhibit superior biodegradability, biocompatibility, and colloidal stability in wound healing and can play a role in promoting healing through their nanoscale properties or as carriers of other drugs. By combining the advantages of both technologies, several outstanding and efficient wound dressings have been developed. In this paper, we classify nano-based hydrogel dressings into four categories: hydrogel dressings loaded with a nanoantibacterial drug; hydrogel dressings loaded with oxygen-delivering nanomedicines; hydrogel dressings loaded with nanonucleic acid drugs; and hydrogel dressings loaded with other nanodelivered drugs. The design ideas, advantages, and challenges of these nano-based hydrogel wound dressings are reviewed and analyzed. Finally, we envisaged possible future directions for wound dressings in the context of relevant scientific and technological advances, which we hope will inform further research in wound management.

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“…On one hand, electrospinning combined with physical cross-linking methods, electrostatic spraying, and other technologies, can produce micro-nanofibre membranes with special structures [ [18] , [19] , [20] ] that can achieve high filtration and low-pressure drop resistance. On the other hand, antibacterial substances such as oxides, metals, and other materials can be added to the spinning solution system to achieve the antibacterial function of the fibre membrane [ [21] , [22] , [23] , [24] ]. However, the addition of materials increases the difficulty of spinning, leading to the need for simple methods and adjustment of the complex spinning system.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PVB/AVE NMs as mask filter layer for win-win effects of filtration and antibacterial activity

Lou

Wei

et al. 2023

Journal of Membrane Science

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Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

Cited by 75 publications

References 126 publications

Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties

Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties

Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing

Electrospun PVB/AVE NMs as mask filter layer for win-win effects of filtration and antibacterial activity

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