Designing of pH-responsive ketorolac tromethamine loaded hydrogels of alginic acid: Characterization, in-vitro and in-vivo evaluation

Suhail, Muhammad; Liu, Jiayu; Hsieh, Wan-Chu; Lin, Yueh‐Min; Minhas, Muhammad Usman; Wu, Pao‐Chu

doi:10.1016/j.arabjc.2021.103590

Cited by 14 publications

(4 citation statements)

References 54 publications

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“…They demonstrated that composite was pH sensitive by dynamic swelling and in vitro release studies at acidic and neutral pH (1.2 and 7.4, respectively), and that maximum swelling and higher ketorolac release was observed at pH 7.4. Similar results were reported by the same research group for alginic acid‐graft‐PAAc hydrogel 14 . Sarkar et al 15 determined the release profile of ketorolac from a transdermal film of cellulose nanofibrils/chitosan.…”

Section: Introductionsupporting

confidence: 77%

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Preparation of poly(acrylic acid)/linseed mucilage/chitosan hydrogel for ketorolac release

Rodríguez‐Loredo,

Ovando‐Medina,

Pérez

et al. 2023

Vinyl Additive Technology

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Studies of smart and biocompatible hydrogels have resulted in the development of efficient drug‐delivery systems controlled by external stimuli. Taking inadequate doses of ketorolac could cause health complications in humans. Therefore, it is necessary the development of a polymeric matrix for controlled drug delivery to extend the release of Ketorolac. In this work, acrylic acid was polymerized using ammonium persulfate as initiator and N,N′‐methylenebisacrylamide as a cross‐linking agent, and in the presence of chitosan (Chit) and linseed mucilage (LS) biopolymers to obtain a composite of PAAc/LS/Chit hydrogel which was used for adsorption and release of ketorolac. Hydrogel was characterized by cryo‐scanning electron microscopy (Cryo‐SEM), Fourier transform infrared spectroscopy, and thermogravimetric analysis. The effects of pH on water hydrogel swelling percentage (S), water absorption percentage (W), and ketorolac‐releasing kinetics were studied. SEM analysis showed hydrogel pore size pH‐depending, with micropore diameters ranging between 5 and 10 nm at acidic pH, while for the hydrogel swollen at pH = 9, bigger pores are observed in the range of 30 to 50 nm. It was observed that S and W increased with the pH of the medium with an S of 608% at a pH of 9 following a Fickian behavior of water diffusion into the hydrogel pore and swelling kinetics represented by a second‐order model. Ketorolac kinetic release was well described through the Korsmeyer‐Peppas mathematical model, with the release rate increasing with the pH, extending the total release time of drug to 20 h.

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Section: Introductionsupporting

confidence: 77%

“…Similar results were reported by the same research group for alginic acidgraft-PAAc hydrogel. 14 Sarkar et al 15 determined the release profile of ketorolac from a transdermal film of cellulose nanofibrils/chitosan. They concluded that cellulose nanofibrils significantly prolong the release time of drugs.…”

Section: Introductionmentioning

confidence: 99%

Preparation of poly(acrylic acid)/linseed mucilage/chitosan hydrogel for ketorolac release

Rodríguez‐Loredo,

Ovando‐Medina,

Pérez

et al. 2023

Vinyl Additive Technology

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“…Muhammad Suhail et el. developed an acrylic acid-algin AH hydrogel as a sustainable drug delivery system for ketorolac tromethamine, which is responsive to pH changes [ 42 ]. The pH-responsive property of alginic acid enabled the controlled release of drugs in targeted microenvironments based on changes in acid-base balance, giving rise to dually controlled drug release.…”

Section: Alginate and Ahms In Drug Deliverymentioning

confidence: 99%

Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering

Tong

et al. 2022

Marine Drugs

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In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation properties, good mechanical strengths, and biodegradability. The AHMs have been widely applied in wound dressing, cell culture, tissue engineering, and drug delivery. However, medical applications in different fields require different properties in the AHMs. The drug delivery application requires AHMs to provide optimal drug loading, controlled and targeted drug-releasing, and/or visually guided drug delivery. AHMs for wound dressing application need to have improved mechanical properties, hydrophilicity, cell adhesion, and antibacterial properties. AHMs for tissue engineering need improved mechanical properties that match the target organs, superior cell affinity, and cell loading capacity. Various methods to produce AHMs that meet different needs were summarized. Formulations to form AHMs with improved stability, drug/cell-loading capacity, cell adhesion, and mechanical properties are active research areas. This review serves as a road map to provide insights into the strategies to develop AHMs in medical applications.

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“…Furthermore, the pK a of carboxylic groups of α-L-guluronic acid and β-D-mannuronic acid in alginate is in the range of 3.4 to 3.9, and metformin has a positive charge at pH <2.97. GO sheets form stable dispersions and more negative charge in the pH range of 4-11.5, [37][38][39] which indicates the GO-Met@Alg bead below pH 3 has a positive charge and makes repulsion with cations that decrease metal sorption. This implied that pH of three up to six is favorable.…”

Section: Effect Of Phmentioning

confidence: 99%

Metformin‐graphene oxide/alginate beads for the removal of toxic lead ions from aqueous media; kinetic and equilibrium studies

Abboud

Mollahosseini

Ghaffarinejad

2022

Env Prog and Sustain Energy

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In this study, the Met-GO@Alg as a novel adsorbent was composed of metformin (Met), graphene oxide (GO), alginate beads (Alg) for removal of lead ions from aqueous media. The adsorbent material was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) techniques. The effect of solution pH)5(, adsorbent dosage)20 mg(, contact time)90 min(, temperature and co-existing ions were studied and optimized. The Pb 2+ adsorption nature and mechanism were adopted with various isotherms, kinetics, and thermodynamic models. Hence, the adsorption kinetic process fits with the pseudo-second-order model (R 2 > 0.97) with 95% removal efficiency at 90 min. The adsorption isotherm is well fit to the Freundlich model (R 2 > 0.99) with the maximum adsorption capacity of 370 mg. g À1 .Overall, Met-GO@Alg nanocomposite revealed good efficiency, applicability, and five times reusability.

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Designing of pH-responsive ketorolac tromethamine loaded hydrogels of alginic acid: Characterization, in-vitro and in-vivo evaluation

Cited by 14 publications

References 54 publications

Preparation of poly(acrylic acid)/linseed mucilage/chitosan hydrogel for ketorolac release

Preparation of poly(acrylic acid)/linseed mucilage/chitosan hydrogel for ketorolac release

Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering

Metformin‐graphene oxide/alginate beads for the removal of toxic lead ions from aqueous media; kinetic and equilibrium studies

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