2008
DOI: 10.1002/jbm.a.32168
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Designing tailored biomaterial surfaces to direct keratinocyte morphology, attachment, and differentiation

Abstract: Precisely engineering the surface chemistry of biomaterials to modulate the adsorption and functionality of biochemical signaling molecules that direct cellular functions is critical in the development of tissue engineered scaffolds. Specifically, this study describes the use of functionalized self-assembled monolayers (SAMs) as a model system to assess the effects of biomaterial surface properties on controlling fibronectin (FN) conformation and concentration as well as keratinocyte function. By systematicall… Show more

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Cited by 17 publications
(23 citation statements)
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“…However, due to some disadvantages such as prolonged healing times and limited tissue functionality, alternative biodegradable polymers have been considered. [1][2][3] For skin graft or wound healing studies one of the most commonly used cell types is the human adult low calcium high temperature (HaCaT) cell line. These cell lines are isolated from the periphery of a melanoma of human adult skin.…”
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confidence: 99%
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“…However, due to some disadvantages such as prolonged healing times and limited tissue functionality, alternative biodegradable polymers have been considered. [1][2][3] For skin graft or wound healing studies one of the most commonly used cell types is the human adult low calcium high temperature (HaCaT) cell line. These cell lines are isolated from the periphery of a melanoma of human adult skin.…”
mentioning
confidence: 99%
“…These integrins have receptor sites which exhibit domains for the specific proteins in the extracellular matrix (ECM) to bind. [2] After adhering, the cells aggregate to form clusters or focal adhesion (FA) sites/complexes which communicate with the outer and inner environment of the cell. Hence, a series of Tetracycline, an antibiotic used against a broad range of Gram positive and Gram negative bacteria was encapsulated in microspheres made of poly(3-hydroxybutyric acid) P(3HB), a microbial biodegradable polymer isolated from Bacillus cereus SPV.…”
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confidence: 99%
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