Detecting the role of CCR7-CCL21/CCL19 axis in Breast Cancer Progression and lymph node Metastasis Incidence

Aloss, Kenan; Jdeed, Sham; Alshehabi, Zuheir

doi:10.5958/0974-360x.2018.00043.4

Cited by 3 publications

(1 citation statement)

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“…CCR7 Ligands (CCL19/CCL21) have also been explored as potential biomarkers for screening and survival. In breast cancer, for example, a correlation between CCL19/CCL21 mRNA expression and triple negative receptors, such as PR, ER and Her-2, was recognised and subsequently established as a predictor of poor therapeutic response and outcome [217]. Recently, along with CCR7, CCL21 high expression was indicated as an effective diagnostic marker in gallbladder squamous cell adeno-squamous carcinoma and adenocarcinomas [218].…”

Section: Ccr7/ccl19/ccl21 As a Prognostic Biomarker In Cancermentioning

confidence: 99%

CCR7 as a therapeutic target in Cancer

Salem

Alotaibi

Mroueh

et al. 2021

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Section: Ccr7/ccl19/ccl21 As a Prognostic Biomarker In Cancermentioning

confidence: 99%

CCR7 as a therapeutic target in Cancer

Salem

Alotaibi

Mroueh

et al. 2021

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Expression Level of HSP70 and COX-2 in Breast Cancer Proliferation in Dr. Soetomo General Hospital, Surabaya, Indonesia

Kristian

Sandhika

Heriyawati

2022

RJPT

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Stress and inflammation have significant roles in tumor growth. Heat shock protein 70 (HSP70) is a molecular chaperone under stress conditions, such as carcinogenesis and cancer managements. Cyclooxygenase 2 (COX-2) is an inducible enzyme, regulated in response to variety of proinflammatory agents, like tumor promoters. The overexpression of HSP70 and COX-2 has been shown to be implicated in poor prognosis of cancer patients. There is a high degree of heterogeneity between tumours that can be seen from the different aggressiveness, such as tumor proliferation/growth (tumor size). All of the heterogeneity factors determine the risk of disease progression and therapeutic resistance. The purpose of this study was to analyze the expression of HSP70 and COX-2 in tumour proliferation (T stage) of invasive breast carcinoma of no special type (NST). Sixty samples were tested using an analytical observational design with cross sectional approach. We collected these samples from year 2016 to 2020 and divided them into 4 groups based on T stage (T1, T2, T3, T4). Immunohistochemical staining was performed to detect the expression of HSP70 and COX-2. There were significant differences of HSP70 (p= 0.030) and COX-2 (p=0,000) expression in the four groups There was no significant correlation between HSP70 and COX-2 expression (p=0,181) in the four groups. HSP70 and COX-2 have an important role in tumour proliferation therefore can determine prognosis and targeted therapy in breast cancer patients.

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Potential matrix metalloproteinase-9 inhibitor of aurone compound isolated from Sterculia quadrifida leaves: In-vitro and in-silico studies

Rollando

Warsito

Masruri

et al. 2022

RJPT

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In our previous study, aurone compound were found in the n-butanol fraction of Sterculia quadrifida leaves. The aurone compound (compound 1) had high cytotoxic activity in cell lines with IC50 values of 4.05, 12.53, 15.38, and 25.91 μg/mL in 4T1, MCF7, MDA-MB-435, T47D, respectively. In this study, we performed the MMP-9 enzyme inhibition test with FRET assay, and to deepen the mechanism of action of the compounds use molecular docking and molecular dynamics. The results showed that compound 1 had the MMP-9 enzyme inhibition of 91.23% and IC50 48.27%. Furthermore, molecular docking and molecular dynamic simulation suggest compound 1 interacts firmly and stably at the enzyme catalytic site. In conclusion, this study can provide important information on the development of herbal medicines that are potentially cancer drugs.

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Detecting the role of CCR7-CCL21/CCL19 axis in Breast Cancer Progression and lymph node Metastasis Incidence

Cited by 3 publications

References 0 publications

CCR7 as a therapeutic target in Cancer

CCR7 as a therapeutic target in Cancer

Expression Level of HSP70 and COX-2 in Breast Cancer Proliferation in Dr. Soetomo General Hospital, Surabaya, Indonesia

Potential matrix metalloproteinase-9 inhibitor of aurone compound isolated from Sterculia quadrifida leaves: In-vitro and in-silico studies

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