Determination and Assessment of Glyphosate Exposure Among Farmers from Northern Part of Thailand

Polyiem, Watcharapol; Hongsibson, Surat; Chantara, Somporn; Kerdnoi, Tanyaporn; Patarasiri, Vanvimol; Prapamonto, Tippawan; Sapbamrer, Ratana

doi:10.3923/jpt.2017.97.102

Cited by 6 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, glyphosate was not detected in the urine of nonfarm workers. The geometric means of glyphosate concentrations in the three grower groups were lower than those found in a cohort of general farmers from a previous study in Thailand by Hongsibsong et al [10] but higher than the mean level found in German adults from 2001 to 2015 [28] and the maximum value found in Irish horticultural workers [29]. This may be from patterns or types of herbicides used in those areas.…”

Section: Resultscontrasting

confidence: 62%

“…Glyphosate in the urine samples was measured using a previously published method [10]. In brief, urine samples were derivatized by FMOC-Cl prior to analysis using high performance liquid chromatography (HPLC: Agilent, 1100) equipped with fluorescence detector (FLD: Agilent, 1046A).…”

Section: Methodsmentioning

confidence: 99%

“…Biomarkers of pesticide exposure used to assess pesticide exposure include: (1) cholinesterase enzyme activities including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for assessing the exposure to organophosphate and carbamate containing pesticides; (2) dialkyl phosphate metabolites (DAPs), nonspecific for organophosphates [4–7]; (3) urinary 3-phenoxybenzoic acid (3-PBA), a major metabolite of synthetic pyrethroid[8, 9]; and (4) urinary glyphosate [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Pesticide Exposure of People Living in Agricultural Community, Northern Thailand

Wongta

Sawarng

Tongchai

et al. 2018

Journal of Toxicology

Self Cite

View full text Add to dashboard Cite

Background and Aim Biomarkers of pesticide exposure are generally lacking in communities where agricultural crops are grown. The purpose of this study was to focus on evaluating biomarkers of pesticide exposure in people living in an agricultural area of San Pa Tong District in Chiang Mai Province, northern Thailand. Materials and Methods One hundred and twenty-four participants (38 nonfarm workers, 38 rice growers, 31 longan growers, and 17 vegetable growers) from San Pa Tong District gave consent to participate in the study. Pesticide exposure was assessed by determining acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) levels in blood samples using Ellman's method and measuring 6-dialkylphosphate metabolites (DAPs), 3-phenoxybenzoic acid (3-PBA), and glyphosate in urine samples using chromatographic methods. Results AChE and BChE activities in the nonfarm worker group had higher level than those in the grower groups. DAPs were detected in almost all urine samples and 3-PBA was detected in 12-45% of each group, while glyphosate was found in 11 – 30% among the three groups of growers but not in nonfarm workers. Conclusion In this study, participants living in an agricultural area of San Pa Tong District were exposed to organophosphate, synthetic pyrethroid, and glyphosate through multiple pathways.

show abstract

Section: Resultscontrasting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Pesticide Exposure of People Living in Agricultural Community, Northern Thailand

Wongta

Sawarng

Tongchai

et al. 2018

Journal of Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In 2017, a retrospective study (between 2001 to 2015) in the northeastern Germany found maxima of glyphosate concentration of 1.78 and 2.80 µg/L in German males and females, respectively [14]. A study in Thailand found glyphosate residue as high as 13.7 µg/L in urine of the Northern farmers collected in the morning post-exposure [15] as shown in Table 1. Table 1 Glyphosate concentration in human urine from the studies between 2004 and 2017.…”

Section: Internal Dose Of Glyphosate Exposure In Human Samplementioning

confidence: 99%

“…Iowa [7] Range: Father-Farm = 0.02 -18 µg/L; Mother-Farm = 0.10 -11 µg/L; Child-Farm = 0.02 -18 µg/L; Father-non-Farm = 0.13 -5.4 µg/L; Mother-non-Farm = 0.06-5.0 µg/L; Child-non-Farm = 0.10 -9.4 µg/L; France [8] Maximum: Father = 4.35 µg/L, Child = 2 µg/L, Mother = Not detectable level (LOD = 1 µg/L, LOQ = 2 µg/L) Children Denmark [9] Mean (range) = 1.96 µg/L (0.85 -3.31 µg/L) US. Iowa [10] Maximum Thailand [15] Mean (Northern farmers) = 13.7 µg/L Generally, urinary glyphosate and AMPA levels have tended to be higher in males than females but sex-related differences in physiological determinants of glyphosate and AMPA in urine cannot be elucidated [14]. There were 3 studies analyzing AMPA that reported the major breakdown product of glyphosate.…”

Section: Country Reference Concentrationmentioning

confidence: 99%

Human Exposure to Glyphosate and Methods of Detection: A Review

Chaiklieng

Uengchuen

2020

Walailak J Sci & Tech

View full text Add to dashboard Cite

Glyphosate is a broad-spectrum herbicide used extensively worldwide. The carcinogenic potential of glyphosate has been debated. This review aimed to describe human exposure, report environmental air concentrations in relation to occupational exposure, and identify the methods used to analyze glyphosate or AMPA concentrations. We searched, Google Scholar, Science Direct and PubMed for relevant papers in Thai or English, published from 2004 to 2017. Thus, 16 studies were identified. The results show that glyphosate and aminomethylphosphonic acid (AMPA) are markers of both internal and external exposure dose. Glyphosate is generally detected at concentrations comparable to or higher than AMPA. Human exposure has been assessed with measured levels of glyphosate ranging from 0.02 to 233 µg/L and a range of AMPA of 0.15 to 2.63 µg/L in human urine. The highest concentrations of glyphosate and AMPA found in blood were 171.1×103 and 2,600 µg/L, respectively, from acute poisonings and intentional self-harm. Environmental air concentrations of glyphosate ranged from less than 0.01 to 46.80 µg/m3 in the working field areas. Four methods used to analyze glyphosate and AMPA were identified: ELISA, HPLC-fluorescence/MS, GC-MS, LC-MS. While these results indicate the level of human exposure to glyphosate, the resulting human health effects of exposure are still uncertain. Therefore, there is a need for more investigation into human health risk assessment and application of health surveillance programs, particularly among glyphosate applicators.

show abstract

Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the determination of glyphosate in human urine after pre-column derivatization with 9-fluorenylmethoxycarbonyl chloride

Bressán

Llesuy

Rodríguez

et al. 2021

Journal of Chromatography B

View full text Add to dashboard Cite

Determination and Assessment of Glyphosate Exposure Among Farmers from Northern Part of Thailand

Cited by 6 publications

References 23 publications

The Pesticide Exposure of People Living in Agricultural Community, Northern Thailand

The Pesticide Exposure of People Living in Agricultural Community, Northern Thailand

Human Exposure to Glyphosate and Methods of Detection: A Review

Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the determination of glyphosate in human urine after pre-column derivatization with 9-fluorenylmethoxycarbonyl chloride

Contact Info

Product

Resources

About