2009
DOI: 10.1002/bio.1129
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Determination of enalapril maleate and atenolol in their pharmaceutical products and in biological fluids by flow‐injection chemiluminescence

Abstract: A chemiluminescent method using flow injection (FI) was investigated for rapid and sensitive determination of enalapril maleate and atenolol, which are used in the treatment of hypertension. The method is based on the sensitizing effect of these drugs on the Ce(IV)-sulfite reaction. The different experimental parameters affecting the chemiluminescence (CL) intensity were carefully studied and incorporated into the procedure. The method permitted the determination of 0.01-3.0 microg mL(-1) of enalapril maleate … Show more

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Cited by 10 publications
(8 citation statements)
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“…Since PG drug is so important in treating Type-II diabetes that several analytical techniques were proposed for its analysis, including voltammetry [17], capillary electrophoresis [18], micellar electro-kinetic chromatography [19], liquid chromatography with tandem mass spectrometry [20], flow-injection chemiluminescence [21]. Some potentiometric methods determined the PG drug in its pure form [22], while others were used for the PG determination in pharmaceutical preparations and physiological fluids such as plasma [23], serum [24], and urine samples [25]. However, these methods suffer from small LDR, high DL of > 10 μM [26], low selectivity with some species interference, and long response time [27].…”
Section: Introductionmentioning
confidence: 99%
“…Since PG drug is so important in treating Type-II diabetes that several analytical techniques were proposed for its analysis, including voltammetry [17], capillary electrophoresis [18], micellar electro-kinetic chromatography [19], liquid chromatography with tandem mass spectrometry [20], flow-injection chemiluminescence [21]. Some potentiometric methods determined the PG drug in its pure form [22], while others were used for the PG determination in pharmaceutical preparations and physiological fluids such as plasma [23], serum [24], and urine samples [25]. However, these methods suffer from small LDR, high DL of > 10 μM [26], low selectivity with some species interference, and long response time [27].…”
Section: Introductionmentioning
confidence: 99%
“…That CL mechanism has been already reported for many organic compounds in different chemical families. 2025…”
Section: Resultsmentioning
confidence: 99%
“…A chemiluminescent method using flow injection (FI) was used for determination of enalapril maleate and atenolol in both urine and serum, based on the sensitizing effect of these drugs on the Ce (IV)-sulfite reaction 94 .…”
Section: Chemiluminescence Methodsmentioning
confidence: 99%
“…A chemiluminescence (CL) method using flow injection has been used for the determination of enalapril maleate, based on the reaction of the drug with tris(2,2'bipyridyl)ruthenium(II), Ru(bipyridyl)3(2+) and acidic potassium permanganate 93 . Flow injection (FI) was used for determination of enalapril maleate and atenolol, based on the sensitizing effect of these drugs on the Ce(IV)sulfite reaction 94 . Ramipril can quench the luminescence intensity of the Sm(3+) ion in Sm(3+)-doxycycline complex at 375 nm in sol-gel matrix, with the emission band of ramipril in DMSO at 454 95 .…”
Section: 114mentioning
confidence: 99%