This study was conducted as a descriptive study to determine the relationship between quality of work life, burnout and spiritual well-being in intensive care nurses. The research has been carried out on 211 nurses who work in the intensive care units in three public hospitals located in Turkey's Eastern Anatolia Region. In data collection, a form containing questions about the socio-demographic characteristics of individuals (age, gender, education level, marital status, economic status and receiving spiritual care education), "Spiritual Well-being Scale", "Nursing Work Life Scale" and "Maslach Burnout Scale" were used. T test was used for independent variables in the analysis of the data. In addition, the effect of independent variables on the dependent variable in numerical data was made using multiple regression analysis. In this study, it was determined that the spiritual well-being and emotional exhaustion levels of the nurses were above the middle level, and the mean scores of the nurses' quality of life, depersonalization and personal accomplishment were below the middle level. As a result, it was found that as the spiritual well-being levels of nurses working in intensive care increased, their burnout levels decreased and their work life quality increased. In addition, it was found that nurses who received spiritual care training had higher work life quality and lower burnout levels than nurses who did not receive training.