Determination of Phenylephrine Hydrochloride by Flow Injection Analysis with Chemiluminescence Detection

Abstract

A new method is proposed for the determination of phenylephrine hydrochloride by flow injection analysis with direct chemiluminescence detection. The method is based on the oxidation of the drug by potassium permanganate in sulfuric acid medium at 80°C. The calibration graph is linear over the range 0.03–8 ppm phenylephrine hydrochloride, with a relative standard deviation (n = 51, 0.5 ppm) of 1.1% and sample throughput of 134/h. The influence of 38 different foreign compounds was tested, and the method was applied to the determination of phenylephrine hydrochloride in 8 different pharmaceutical formulations.

Analysis of phenylephrine hydrochloride in pharmaceutical formulations and biological fluids using (2,2′-bipyridyl)ruthenium(ii)-peroxydisulphate chemiluminescence system in a two-chip microdevice

“…10 Several spectrophotometric and flow injection analysis (FIA) methods have been reported for analysis of PEH. 11,[13][14][15][16][17] Most of these methods generally suffer from low sensitivity and being uneconomical due to high reagent consumption and excessive waste generation. The FIA-CL method that has been reported involves the use of very harsh conditions such as high acid concentration and high flow rates, in addition it requires heating of the reaction coil at 80 C. 17 Here, we propose a CL method that uses mild conditions and consumes only minute quantities of reagents.…”

Determination of Phenylephrine Hydrochloride in Pharmaceutical Preparations Using Spectrophotometric Method

“…Various methods reported in literature for analysis of phenylephrine hydrochloride. Examples of these methods are conductometric titration [6], voltammetry [7][8][9], thin-layer chromatography [10], high-performance liquid chromatography (HPLC) [11][12][13][14], flow injection [15][16][17], and fluorescence [18]. Among the different techniques, the most popular and simple method for rapid and trace analysis of drugs is spectrophotometry [19][20][21][22][23][24][25][26].…”

Development of a flow injection chemiluminescent assay for the quantification of lipid hydroperoxides

“…It has many other benefits over static CL and LC-CL approaches (12). It has been used to measure antioxidant activity (13), metal ions (14), pesticides (15), and phenylephrine hydrochloride (16). In all cases, the methods were reported as being sensitive, highly reproducible, and rapid.…”