Development and characterization of alginate coated low molecular weight chitosan nanoparticles as new carriers for oral vaccine delivery in mice

Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice

“…Huang et al also reported that no difference in growth performance was found in a broiler chicken study that used a high chitosan dose (150 mg/kg) [12]. Differences between the dosage, molecular weight, purity, or solubility of the chitosan used in this experiment and others may account for the contrary results [16]. …”

Polyelectrolyte complex containing silver nanoparticles with antitumor property on Caco-2 colon cancer cells

“…Such polymers have numerous applications in the cosmetic, food and pharmaceutical industries, whereas theses materials have some properties such as, low toxicity, stability, mucoadhesivity, biocompatibility and biodegradability [4]. On the other hand, the sodium alginate (ALG) is an anionic polysaccharide which can easily interact with CS and TMC for form polyelectrolyte complexes (PECs) via electrostatic interactions and intermolecular/intramolecular secondary forces [7]. PECs have received much attention in the last years, since they are used for the preparation of drug carriers and tissue engineering scaffolds [8,9].…”

Synthesis and evaluation of oxidation-responsive alginate-deferoxamine conjugates with increased stability and low toxicity

“…As a result, carriers with oxidative-response may be a potential candidate for DFO conjugation under the condition of iron overload. Alginate is a naturally occurring polysaccharide composed of ␣-l-guluronate (G unit) and ␤-d-mannuronate (M unit) arranged as linear homopolymeric and heteropolymeric blocks and it has been widely applied in drug, gene, and cell delivery systems due to its biocompatibility and non-immunogenicity (Biswas, Chattopadhyay, Sen, & Saha, 2015;Martín et al, 2015;Tian, Han, Tan, & You, 2014). In the case of drug carriers, it has been reported that alginate conjugation prolonged the half-life and improved the solubility of the drugs (Brudno et al, 2014;Imai, Fujii, Shiraishi, & Otagiri, 1997;Sreenivasan, 2014).…”