Development and Evaluation of Tocopherol-Rich Argan Oil-Based Nanoemulsions as Vehicles Possessing Anticancer Activity

Jordan, Melanie A.; Nayel, Amy; Brownlow, Bill; Elbayoumi, Tamer

doi:10.1166/jbn.2012.1460

Cited by 29 publications

(66 citation statements)

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Section: Ne Containing Eucalyptus Oil (Eucalyptus Globulus)mentioning

confidence: 98%

“…In vitro antiparasitic activity (Baldissera et al, 2013) Anise (25, 50 and 75% of oil phase) Soy lecithin (5%) HPH In vitro antimicrobial activities (Topuz et al, 2016) Argan Polyethoxylated solutol HS-15 EPI In vitro cytotoxic activity (Jordan et al, 2012) Babassu (5%) Mixture of sorbitan monooleate and PEG-54 castor oil (10%) PIT Pharmaceutical and cosmetic matrices (Gumiero, Filho,2012) Carqueja-doce (3.32%) Polysorbate (0.77%) SE In vitro antifungal activity (Danielli et al, 2013) Casca-de-anta (4%) Polysorbate 20 (1%) Sorbitan monooleate (1%) HPH In vitro cytotoxic activity (Gomes et al, 2013) Cinnamon (6%) Polysorbate 80 (18%) EPI In vitro antibacterial activity (Nirmala et al, 2013) Cinnamon bark (1%)…”

Section: Hphmentioning

confidence: 99%

“…The IC50 values of the combination argan oil and TPGS (40-80% w/w, emulsifiers) were 5 -9 fold lower compared to TPGS-free and argan oil-free control NE. Argan oil NE, stabilized with vitamin E TPGS and solutol HS mixtures, demonstrated significant pro-apoptotic effect on both test cancer cell lines, indicating built-in anticancer properties for such an NE platform, potentially enhancing overall antineoplastic effects of incorporated candidate chemotherapeutic agents (Jordan et al, 2012).Most often, VO are incorporated into NE, not just for nanoencapsulating several therapeutic classes of drugs inside an oil core, but also to enhance the action of these compounds. This feature also enables the use of much lower concentrations of active substances eliminating problems related to toxicity, resistance and side effects.…”

mentioning

confidence: 99%

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The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation in nanoemulsions is considered a promising strategy to facilitate the applicability of these natural compounds and to potentiate the actions. These formulations offer several advantages for topical and systemic delivery of cosmetic and pharmaceutical agents including controlled droplet size, protection of the vegetable oil to photo, thermal and volatilization instability and ability to dissolve and stabilize lipophilic drugs. For these reasons, the aim of this review is to report on some characteristics, preparation methods, applications and especially analyze recent research available in the literature concerning the use of vegetable oils with therapeutic characteristics as lipid core in nanoemulsions, specially from Brazilian flora, such as babassu (Orbignya oleifera), aroeira (Schinus molle L.), andiroba (Carapa guaianiensis), casca-de-anta (Drimys brasiliensis Miers), sucupira (Pterodon emarginatus Vogel) and carqueja doce (Stenachaenium megapotamicum) oils.Uniterms: Plant oils/nanoemulsions/preparation. Plant oils/biological applications. INTRODUCTIONThe use of submicrometric colloidal nanocarriers such as nanoparticles (NP) lipid and polymeric, nanoemulsions (NE), microemulsions (ME), liposomes, and polymeric micelles is considered a promising system in the pharmaceutical field, because they have numerous advantages over traditional formulations such as: sustained release of the active element; solubilization of lipophilic molecules; use for different routes of administration; protection from chemical and enzymatic degradation of labile molecules; reduction of vegetable oils (VO) volatilization, side effects and dose (Mäder, Mehnert, 2005;Mehnert, Mäder, 2001;Gref, Couvreour, 2006;Couvreur, Vauthier, 2006; Panyam, Labhasetwar, 2003;Soppimath et al., 2001;Ai et al., 2011; Contri et al., 2012;Contri et al., 2014;Dimer et al., 2014;Severino et al., 2015;Frank et al., 2015;Asbahani et al., 2015). However, all systems differ thermodynamic stability, structure, chemical composition, efficiency encapsulation and types of application (Mäder, Mehnert, 2005;Ai et al., 2011).The development of suitable nanocarriers for pharmaceutical or cosmetic application requires the adequate selection of their adjuvants such as polymers for nanocapsules (NC), surfactants, and oils (Schaffazick et al., 2003;Alvarez-Román et al., 2001;Bouchemal et al., 2004;Friedrich et al., 2008). Recently, special attention has been given to the type of oily phase used as the core in the preparation of NE. VO has been preferred not only due to the concept that it is safe and biocompatible, but mainly because of the diversity of benefits, and the complex composition of fatty acids can exercise under the skin, protecting it against dehydration, solar radiation, inflammation, insect attack, microorganisms, and viruses (Tadros, Kessell, 2004;Bloise, 2003;Oyedeji, Okeke, 2010;Bakkali et. al., 2008;Harris, 2002; Contri et al, ...

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Section: Ne Containing Eucalyptus Oil (Eucalyptus Globulus)mentioning

confidence: 98%

Section: Hphmentioning

confidence: 99%

mentioning

confidence: 99%

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The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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“…Different types of nanostructures, including mesoporous silica nanoshells, dendrimers, supramagnetic iron cores, nanosuspensions, gold nanoparticles, nanolipogels, nanoemulsions, carbon nanotubes, titanium oxide nanoparticles, liposomes, polymeric miscelles, and other lipid based nanoparticles have been used as drug delivery vehicles and facilitators of targeted cancer therapies. [148][149][150][151][152][153][154][155] Although most of the cancer nanodiagnostic and nanotherapy studies are still in their infancy, it seems clear that nanotechnology will play an important role in colorectal cancer diagnostics and therapeutics in the future.…”

Section: Cancer Nanotechnologymentioning

confidence: 99%

Prospects of ‘Omics Based Molecular Approaches in Colorectal Cancer Diagnosis and Treatment in the Developing World: A Case Study in Cape Town, South Africa

Adeola¹,

Goosen²,

Goldberg³

et al. 2014

Colorectal Cancer - Surgery, Diagnostics and Treatment

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“…19 Our current project employs NEs that rely on active amphiphilic tocopheryl moieties, which were utilized previously, 25 successfully loaded with the proapoptotic lipophilic drug candidate Gen. Additional mucoadhesion properties -acquired via chitosan (Chito) layering of Gencontaining NE particles -were investigated to produce pharmaceutically stable and acceptable mucoadhesive buccal platforms, namely liquid sprays and solid tablets. One of the major advantages of using multilayer NEs as delivery systems is that the properties of the Chito interfacial layer surrounding the oil/emulsifier interior can be tuned through careful design of system composition and preparation conditions.…”

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confidence: 99%

Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics

Gavin¹,

Pham²,

Wang³

et al. 2015

IJN

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Oral cavity and oropharyngeal cancers are considered the eighth most common cancer worldwide, with relatively poor prognosis (62% of patients surviving 5 years, after diagnosis). The aim of this study was to develop a proof-of-concept mucoadhesive lozenge/buccal tablet, as a potential platform for direct sustained delivery of therapeutic antimitotic nanomedicines. Our system would serve as an adjuvant therapy for oral cancer patients undergoing full-scale diagnostic and operative treatment plans. We utilized lipid-based nanocarriers, namely nanoemulsions (NEs), containing mixed-polyethoxylated emulsifiers and a tocopheryl moiety–enriched oil phase. Prototype NEs, loaded with the proapoptotic lipophilic drug genistein (Gen), were further processed into buccal tablet formulations. The chitosan polyelectrolyte solution overcoat rendered NE droplets cationic, by acting as a mucoadhesive interfacial NE layer. With approximate size of 110 nm, the positively charged chitosan-layered NE (+25 mV) vs negatively charged chitosan-free/primary aqueous NE (−28 mV) exhibited a controlled-release profile and effective mucoadhesion for liquid oral spray prototypes. When punch-pressed, porous NE-based buccal tablets were physically evaluated for hardness, friability, and swelling in addition to ex vivo tissue mucoadhesion force and retention time measurements. Chitosan-containing NE tablets were found equivalent to primary NE and placebo tablets in compression tests, yet significantly superior in all ex vivo adhesion and in vitro release assays ( P ≤0.05). Following biocompatibility screening of prototype chitosan-layered NEs, substantial anticancer activity of selected cationic Gen-loaded NE formulations, against two oropahryngeal carcinomas, was observed. The data strongly indicate the potential of such nanomucoadhesive systems as maintenance therapy for oral cancer patients awaiting surgical removal, or postresection of identified cancerous lesions.

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Development and Evaluation of Tocopherol-Rich Argan Oil-Based Nanoemulsions as Vehicles Possessing Anticancer Activity

Cited by 29 publications

References 0 publications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Prospects of ‘Omics Based Molecular Approaches in Colorectal Cancer Diagnosis and Treatment in the Developing World: A Case Study in Cape Town, South Africa

Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics

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