Development and validation of Alzheimer’s Disease Animal Model for the Purpose of Regenerative Medicine

Goodarzi, Parisa; Payab, Moloud; Alavi-Moghadam, Sepideh; Larijani, Bagher; Rahim, Fakher; Bana, Nikoo; Sarvari, Masoumeh; Adibi, Hos­sein; Heravani, Najmeh Foroughi; Hadavandkhani, Mahdieh; Arjmand, Babak

doi:10.1007/s10561-019-09773-8

Cited by 36 publications

(21 citation statements)

References 64 publications

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“…Stem cell-based therapies are becoming increasingly important in the treatment of chronic and long-lasting diseases, including osteoporosis, as they could enable curative and personalized regenerative medicine approaches. Several different types of stem cells have been evaluated to modulate osteoporosis, including embryonic, induced pluripotent, and MSCs [ 165 , 166 , 167 , 168 , 169 ]. Among them, MSCs are critical candidates for bone regenerative medicine, as they have advantages over other types of stem cells clinically, including ease of harvesting, immunosuppressive outcomes, and fewer ethical concerns [ 170 , 171 , 172 ].…”

Section: Therapeutic Approach and Novel Strategiesmentioning

confidence: 99%

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Noh

Yang

Jung

2020

IJMS

184

121

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Osteoporosis is the most common chronic metabolic bone disease. It has been estimated that more than 10 million people in the United States and 200 million men and women worldwide have osteoporosis. Given that the aging population is rapidly increasing in many countries, osteoporosis could become a global challenge with an impact on the quality of life of the affected individuals. Osteoporosis can be defined as a condition characterized by low bone density and increased risk of fractures due to the deterioration of the bone architecture. Thus, the major goal of treatment is to reduce the risk for fractures. There are several treatment options, mostly medications that can control disease progression in risk groups, such as postmenopausal women and elderly men. Recent studies on the basic molecular mechanisms and clinical implications of osteoporosis have identified novel therapeutic targets. Emerging therapies targeting novel disease mechanisms could provide powerful approaches for osteoporosis management in the future. Here, we review the etiology of osteoporosis and the molecular mechanism of bone remodeling, present current pharmacological options, and discuss emerging therapies targeting novel mechanisms, investigational treatments, and new promising therapeutic approaches.

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Section: Therapeutic Approach and Novel Strategiesmentioning

confidence: 99%

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Noh

Yang

Jung

2020

IJMS

184

121

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show abstract

“…However, there are several parameters which need to be optimized for maximizing stem cell-based therapies potential. In this context, various basic and clinical studies related to the effects of stem cell-based therapies on diseases with no definite treatments were performed (22,98,99). Accordingly, some investigations were also conducted in the field of stem cell therapy for osteoporosis.…”

Section: Cell Therapy As a Novel Approachmentioning

confidence: 99%

“…In this respect, there is no practical pharmaceutical cure (18). Recently, stem cell therapies have attained remarkable clinical consideration with a promising strategy for regenerative medicine and tissue engineering to treat various types of diseases including osteoporosis (19)(20)(21)(22)(23)(24)(25)(26). Herein, discuss the effects of stem cell-based therapies in osteoporosis is the main objective of this review.…”

Section: Introductionmentioning

confidence: 99%

Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

et al. 2020

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“…Study Alzheimer's disease Genetically or pharmacologically upregulating growth factors like brain-derived neurotrophic factor, IGF-1, nerve growth factor, and vascular endothelial growth factor that induce neurogenesis (25). (6,(35)(36)(37)(38)(39). Cardiovascular diseases are a major area of concern as they have a high incident, morbidity and mortality rate and include a variety of chronic conditions such as myocardial infarction (MI), atherosclerosis and aneurysms.…”

Section: Neural Precursor Cell Transplantation Effects On Myelinationmentioning

confidence: 99%

“…In this case, the more suitable model is one that is phylogenetically closest to human species. Since tests and researches in humans have been banned and can raise a lot of ethical problems, animals are ideal alternatives that provide a possibility for scientists to do different studies (6). Animal modeling leads to extend science boundaries and astonishing improvements in clinical findings.…”

Section: Animal Models In Biomedicine Studiesmentioning

confidence: 99%