Development and Validation of Capillary Electrophoresis Method for Simultaneous Determination of Six Pharmaceuticals in Different Food Samples Combining On-line and Off-line Sample Enrichment Techniques

Reddy, A. Vijaya Bhaskar; Yusop, Zulkifli; Jamil, Nur Hidayati; Majid, Zaiton Abdul; Aris, Azmi

doi:10.1007/s12161-017-1024-x

Cited by 15 publications

(4 citation statements)

References 36 publications

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“…The chelating effect of Tris in a ternary coordination of penicillin/Zn 2+ /Tris was shown to be responsible for stabilization, with the Zn-bound hydroxyl group of Tris serving as a powerful nucleophile to attack the β-lactam carbonyl group. An analogous mechanism was described for hydrolytic in metallo-β-lactamase enzymes, in which two dominant metals were located in their active sites. One is essential for catalysis and the other is essential for stabilizing the reaction intermediate. − , In the AMX/Zn/goethite system, the abundance of hydroxyl groups on the crystallographic surface of goethite offer the sufficient reactive sites to form hydrogen and coordination bonds, which in turn stabilize the ternary intermediates.…”

Section: Resultsmentioning

confidence: 83%

“…43 The chelating effect of Tris in a ternary coordination of penicillin/ Zn 2+ /Tris was shown to be responsible for stabilization, with the Zn-bound hydroxyl group of Tris serving as a powerful nucleophile to attack the β-lactam carbonyl group. An analogous mechanism was described for hydrolytic in metallo-β-lactamase enzymes, 41 in which two dominant metals were located in their active sites. One is essential for catalysis and the other is essential for stabilizing the reaction intermediate.…”

Section: Environmental Science and Technologymentioning

confidence: 83%

“…As the pH changed from 5.5 to 10, a few parameters in penicillin/Zn/goethite system would be altered, including the adsorption amount of Zn, species of adsorbed Zn and penicillin antibiotics, and surface charge of goethite. Specifically, because of the multiple pK a values of AMX (2.4, 7.4, and 9.6) and PG (2.7), 41 AMX would exist as zwitterion AMX, AMX − , and AMX 2− , whereas anionic PG − was the dominant species of PG in this pH range (Figure S14). Compared to PG hydrolysis, the similar trend for AMX degradation was observed (Figure 3b), suggesting that the varied charge of AMX might have little influence on its hydrolysis process.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Rapid Hydrolysis of Penicillin Antibiotics Mediated by Adsorbed Zinc on Goethite Surfaces

Feng

Ling

Wang

et al. 2019

Environ. Sci. Technol.

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The soil environment is an important sink for penicillin antibiotics released from animal manure and wastewater, but the mineral-catalyzed transformation of penicillins in soil has not been well studied. To simulate this environmental process, we systematically investigated the behavior of penicillin G and amoxicillin, the two most widely-used penicillin antibiotics, in the presence of goethite and metal ions. The results demonstrated that Zn ions significantly promoted the hydrolysis of penicillins in goethite suspensions, as evidenced by the degradation rate nearly 3 orders of magnitude higher than that of the non-Zn-containing control. The spectroscopic analysis indicated that the specific complexation between penicillins, adsorbed Zn, and goethite was responsible for the enhanced degradation. Metastable interactions, involving hydrogen bonds between carbonyl groups in the β-lactam ring and the double/triple hydroxyl groups on goethite surface, and coordination bonding between carboxyl groups and surface irons were proposed to stabilize the ternary reaction intermediates. Moreover, the surface zinc-hydroxide might act as powerful nucleophile to rapidly rupture the β-lactam ring in penicillins. This study is among the first to identify the synergic roles of Zn ion and goethite in facilitating penicillin degradation and provides insights into β-lactam antibiotics to assess their environmental risk in soil.

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Section: Resultsmentioning

confidence: 83%

Section: Environmental Science and Technologymentioning

confidence: 83%

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Hydrolysis of Penicillin Antibiotics Mediated by Adsorbed Zinc on Goethite Surfaces

Feng

Ling

Wang

et al. 2019

Environ. Sci. Technol.

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“…25 It is worth noting that when the pHpzc of FeOOH becomes lower than the system's pH, the surface of FeOOH changes from positive to negative. However, given that the majority of PG is negatively charged when pH > 2.7 (pK a ), 26 this negative charge on the FeOOH surface is not conducive to PG adsorption.…”

Section: Hypothesis Ii: Reaction Ratesmentioning

confidence: 99%

Selective Removal of Penicillin Antibiotics in Wastewater by Rapid Hydrolysis in Goethite-Zn(II) System

Liu,

Meng,

et al. 2024

ACS EST Water

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The high concentration of penicillin antibiotics in wastewater inhibits the function of biological treatment systems. In this study, we optimized the goethite (FeOOH)−Zn(II) system and used the hydrolysis pretreatment process for the selective removal of penicillin antibiotics from pharmaceutical wastewater. The results showed that penicillin antibiotics could be rapidly and completely hydrolyzed in 20 min with an FeOOH concentration of 500 mg/L and a zinc ions concentration of 30 μM, with a premixing time of 2 h at pH 8.2 and room temperature. The influence of cations on the system was found to be negligible, while phosphate and natural organic matter (NOM) had significant impacts on penicillin degradation, followed by that of bicarbonate. A mechanistic study suggested that these anions reduced the active sites of FeOOH−Zn(OH) 2 and affected the interaction between FeOOH and penicillin. Additionally, steric hindrance and hydrogen bond competition effects cannot be ignored. Furthermore, we proposed applying ferric chloride, which effectively pretreated the aforementioned interfering substances. Eventually, penicillin antibiotics were rapidly hydrolyzed in wastewater by the FeOOH−Zn(II) system effectively in 40 min. The findings in this study demonstrate that the proposed approach enhances the hydrolysis of penicillin antibiotics and may serve as a viable pretreatment technology for antibiotic wastewater.

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Input of Electroanalytical Methods for the Determination of Diclofenac: A Review of Recent Trends and Developments

et al. 2021

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Diclofenac (DCL) is a nonsteroidal anti-inflammatory commonly prescribed to treat inflammatory joint diseases and mild to moderate pain. DCL residues have often been detected in freshwater environments and it belongs to the list of emerging pollutants (EPs) because of the risk it presents for health and environment. Many studies have described the potential effects of DCL on organisms when exposed to environmental levels ranging from a few ng L À 1 to tens of μg L À 1 in surface water. Until now, its detection essentially depends on conventional techniques, such HPLC and GC/MS. Although these analytic techniques are very robust, they are expensive, require experts, and are not portable. Electrochemical sensors are an attractive alternative. They provide many benefits over thermal, optical, and piezoelectric detection including ease of use, rapidity, costeffectiveness, high sensitivity and selectivity, ease of miniaturization and robustness. The aim of this review is to report electrochemical methods used for the detection of DCL and to describe strategies for improving performances of each sensors.

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Development and Validation of Capillary Electrophoresis Method for Simultaneous Determination of Six Pharmaceuticals in Different Food Samples Combining On-line and Off-line Sample Enrichment Techniques

Cited by 15 publications

References 36 publications

Rapid Hydrolysis of Penicillin Antibiotics Mediated by Adsorbed Zinc on Goethite Surfaces

Rapid Hydrolysis of Penicillin Antibiotics Mediated by Adsorbed Zinc on Goethite Surfaces

Selective Removal of Penicillin Antibiotics in Wastewater by Rapid Hydrolysis in Goethite-Zn(II) System

Input of Electroanalytical Methods for the Determination of Diclofenac: A Review of Recent Trends and Developments

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