Development and Validation of Uv Spectrophotometric Estimation of Ebastine in Bulk and Tablet Dosage Form Using Area Under Curve Method

Dahivadkar, Manish Sudhakar; Jain, Hemant Kumar; Gujar, Kishore N.

doi:10.7897/2230-8407.04645

Cited by 11 publications

(5 citation statements)

References 3 publications

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“…On the other hand, it may be used to analyze the possible impact of formulation and manufacturing factors on the biopharmaceutical characteristics of the tablet, as well as a quality control tool to evaluate consistency. [16][17][18][19][20][21][22][23]…”

Section: Discussionmentioning

confidence: 99%

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Perveen,

Jia Min,

Hasan Khan

2023

PPIJ

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Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that is widely used in the treatment of heart diseases and hypertension.Objectives: To compare the percentage purity of several brands of Lisinopril tablets available in the Malaysian Outlets by the UV spectrophotometric and the Fourier-Transform Infrared Spectroscopic methods (FTIR) and to evaluate the time taken for each brand of Lisinopril tablets to dissolve during disintegration analysis. Method:For UV spectrophotometric method, different brands of Lisinopril tablets were diluted with distilled water and undergone a series of dilutions. The absorbance of the diluted sample solutions were measured using a UV spectrometer. The absorbance revealed the concentration of Lisinopril in the sample solution. For FTIR method, the different brands of Lisinopril powders were placed on the diamond crystal plate and pressure was applied. The spectrum of each brand was measured using FTIR spectrometer. The spectrum revealed the functional group of each Lisinopril brand and compared their purity.Results: For UV spectrophotometric method, only Brand A and C were within the limit specified by B.P. and U.S.P. For FTIR method, structural characterization of all brands of Lisinopril tablets was identified. Conclusion:It was concluded that Brand A was the best among 3 brands of Lisinopril used in this research.

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Section: Discussionmentioning

confidence: 99%

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Perveen,

Jia Min,

Hasan Khan

2023

PPIJ

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“…This wavelength range is selected from area under curve vs. concentration. The area under the curve for first and second derivative are depended on the following theoretical equations 16,17,18…”

Section: Methodsmentioning

confidence: 99%

Development of Spectrophotometric Method for the Estimation of Baclofen Drug

Falih¹,

Abbas²,

Hussain³

et al. 2018

Int. Res. J. Pharm.

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Accurate, direct and inexpensive spectrophotometric methods have been used for simultaneous estimation of Baclofen in bulk and tablet dosage form. The proposed methods were applied in the wide concentration ranges of (50-450 mg/L). The detection limits were (0.451) for AUC1 and (0.520) for AUC2. The limit of quantitation was found to be (1.366) for AUC1 and (1.576) for AUC2. The results were analyzed statistically by using recovery and relative standard deviation studies.

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“…A simple, accurate UV-Visible double beam spectrophotometric method was developed by Jadhav PB et al, 56 for the estimation of bosutinib in bulk and tablet dosage form. A simple, precise UV-Visible double beam spectrophotometer was introduced by Chaitanya G et al, 57 for the determination of nilotinib hydrochloride in bulk and capsule dosage form at 263 ± 0.2 nm.…”

Section: Fig 2: Mechanism Of Tyrosine Kinase Inhibitorsmentioning

confidence: 99%

Untitled

2022

IJPSR

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Tyrosine kinase inhibitors generally having a narrow therapeutic window and large inter-patient variability. In order to support its therapeutic drug monitoring, fast and accurate methods are needed to supporting the pharmacokinetic-guided dosing in patients treating with various tyrosine kinase inhibitors (TKIs) either alone or in combination in bulk, formulations or human plasma using HPLC and detection with tandem mass spectrometry (HPLC-MS/MS), gas chromatography with mass spectrometry, spectrofluorimetry and UV-Visible spectrometry. Literature suggested that the methods developed and validated are good for accuracy, precision, and assay for all TKIs studied. These methods are also applied for routine therapeutic drug monitoring and investigator-initiated research. In this review, we described different analytical methods used for the qualitative and quantitative estimation of all TKIs investigated till 2020 in assessing the quality of drugs by using HPLC, LC-MS, HPTLC, UPLC, UV-Visible spectrophotometry, spectrofluorimetry with a huge survey from the research articles published in various pharmaceutical and analytical chemistry journals. From this assessment, these methods were found to be superior based on the quantitative analysis of drugs in API, formulations, biological fluids such as serum and plasma. Detailed validation parameters are also given for the methods that help the researchers select suitable analytical techniques based on the information sought.

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Development and Validation of Uv Spectrophotometric Estimation of Ebastine in Bulk and Tablet Dosage Form Using Area Under Curve Method

Cited by 11 publications

References 3 publications

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Development of Spectrophotometric Method for the Estimation of Baclofen Drug

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