2004
DOI: 10.1016/j.taap.2003.11.002
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Development of an in vitro blood–brain barrier model—cytotoxicity of mercury and aluminum

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Cited by 63 publications
(45 citation statements)
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“…In previous studies (McAmis et al 2003;Wolf & Baynes 2006), we found that the anticancer quinones depleted ATP and caused a barrier dysfunction. In other studies, mercury caused ATP depletion along with barrier dysfunction (Toimela et al 2004) and cadmium caused ATP depletion and increased permeability in renal epithelial cells (Stinson et al 2003). These changes may have just been simultaneous occurrences, but the sulfhydryl reagent, iodoacetate, depletes ATP prior to the appearance of a barrier dysfunction in EC (Wilson et al 1990).…”
Section: Discussionmentioning
confidence: 94%
See 1 more Smart Citation
“…In previous studies (McAmis et al 2003;Wolf & Baynes 2006), we found that the anticancer quinones depleted ATP and caused a barrier dysfunction. In other studies, mercury caused ATP depletion along with barrier dysfunction (Toimela et al 2004) and cadmium caused ATP depletion and increased permeability in renal epithelial cells (Stinson et al 2003). These changes may have just been simultaneous occurrences, but the sulfhydryl reagent, iodoacetate, depletes ATP prior to the appearance of a barrier dysfunction in EC (Wilson et al 1990).…”
Section: Discussionmentioning
confidence: 94%
“…Effects of heavy metals on endothelial barrier function have been noted previously. Mercury, at 10lM concentration, caused a significant increase in low molecular weight fluorescein leakage in a blood-brain barrier model using transformed EC (Toimela et al 2004). A review (Nolan & Shaikh 1986) summarized earlier studies and suggested that the vascular endothelium was a primary target for cadmium and that the result was an increase in vascular permeability in a number of tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Our results indicate that the studied hESC-RPE cells have electrical impedance properties that are near to in vitro cultured human RPE [7,13,18] (Table 2). In previous studies, hESC-RPE cells had greater TER [27,31] than ARPE-19 cells [6,14,26]. We used ARPE-19 cells as controls to model immature epithelia.…”
Section: Discussionmentioning
confidence: 99%
“…In general, TER measurements have some drawbacks: Firstly, TER is often measured with simple handheld devices [2,5,9,16,18,26,27]. Thus, the geometry between the electrodes and the cell culture inserts vary from measurement to measurement and produces inaccuracy in the results.…”
Section: Introductionmentioning
confidence: 99%
“…Mercury can cause immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining/associated with autistic disorders, and these similarities extend to neuroanatomy, neurotransmitters, and biochemistry (Stringari et al 2008;Toimela et al 2004;Waly et al 2004;Blaylock 2008;Blaylock and Struneka 2009;Danscher et al 1990;Fonfria et al 2005;Huang et al 2008;Olanow and Arendash 1994). Furthermore, a review of molecular mechanisms indicates that Hg exposure can induce death, disorganization and/or damage to selected neurons in the brain similar to that seen in recent brain pathology studies of patients diagnosed with an ASD, and this alteration may likely produce the symptoms by which ASDs are diagnosed (Lopez-Hertado and Prieto 2008;Kern 2003;Kern and Jones 2006).…”
Section: Introductionmentioning
confidence: 99%