Development of an Ultra-micro Sample Injector for Gas Chromatography Using an Ink-jet Microchip

Nishiyama, Takahide; Endo, Fumihiro; Eguchi, Hiroko; Nakagama, Tatsuro; Seino, Nobuko; Shinoda, Masaki; Shimosaka, Takuya; Hobo, Toshiyuki; Uchiyama, Katsumi

doi:10.2116/analsci.23.389

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…These include biosensors, single molecule florescence analysis, a sample introduction device for inductively-coupled plasma, gas chromatography, capillary electrophoresis, atomic emission detection, spotting device for protein analysis in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF-MS), DNA micro array sample spotting, protein crystallization and drug delivery systems. [21][22][23][24][25][26] Theoretically, the piezoelectric inkjet devices can be used as a means of introducing liquid samples and nanoparticles or reagents into the mass spectrometer ion source for different applications.…”

Section: Introductionmentioning

confidence: 99%

Technical Report: Development of a Piezoelectric Inkjet Dopant Delivery Device for an Atmospheric Pressure Photoionization Source with Liquid Chromatography/Mass Spectrometry

Amad

Sioud

et al. 2013

Eur J Mass Spectrom (Chichester)

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This paper describes a simple, robust and integrated piezoelectric actuated printhead as a dopant delivery system for atmospheric pressure photoionization with liquid chromatography/mass spectrometry. The newly designed dopant delivery system avoids problems associated with traditional liquid delivery systems such as solvent immiscibility, backpressure and increased post-column dead volume issues. The performance of the new device was tested and evaluated using chlorobenzene as a dopant with a test mixture consisting of 18 different polycyclic aromatic hydrocarbons (PAHs). The results show that the new system works robustly at low dopant consumption level (1.6 uL min(-1)), consuming only approximately 5% of the amount used by conventional sources. The low dopant consumption has resulted in up to a 20-fold reduction in signal intensity of tested PAH molecules, but has led to less presence of background cluster ions and dopant trace contaminant background ions in the source area. Consequently, all tested PAHs were detected with excellent signal-to-noise ratio with at least two- to ten-fold improvements in the limit of detection and quantification compared to those obtained with traditional dopant assistance using a post-column addition method.

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Section: Introductionmentioning

confidence: 99%

Technical Report: Development of a Piezoelectric Inkjet Dopant Delivery Device for an Atmospheric Pressure Photoionization Source with Liquid Chromatography/Mass Spectrometry

Amad

Sioud

et al. 2013

Eur J Mass Spectrom (Chichester)

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Natural isoquinoline alkaloids: binding aspects to functional proteins, serum albumins, hemoglobin, and lysozyme

Khan

Kumar

2015

Biophys Rev

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The putative anticancer alkaloids berberine, palmatine, jatrorrhizine, and sanguinarine are known to bind to nucleic acids. To develop them as potential drugs for therapeutic use, their binding affinity to functional proteins and mode of transport in the circulatory system need to be clearly understood. Towards this, many studies on their binding aspects to proteins have been reported and a considerable amount of data, mostly of biophysical nature, exists in the literature. The importance of these natural isoquinoline alkaloids and the recent literature on their interaction phenomena with functional proteins, serum albumins, hemoglobin, and lysozyme are presented in this review.

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Accurate nano-injection system for capillary gas chromatography

Zeng¹,

Seino²,

Nakagama³

et al. 2009

Journal of Chromatography A

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Development of an Ultra-micro Sample Injector for Gas Chromatography Using an Ink-jet Microchip

Cited by 4 publications

References 22 publications

Technical Report: Development of a Piezoelectric Inkjet Dopant Delivery Device for an Atmospheric Pressure Photoionization Source with Liquid Chromatography/Mass Spectrometry

Technical Report: Development of a Piezoelectric Inkjet Dopant Delivery Device for an Atmospheric Pressure Photoionization Source with Liquid Chromatography/Mass Spectrometry

Natural isoquinoline alkaloids: binding aspects to functional proteins, serum albumins, hemoglobin, and lysozyme

Accurate nano-injection system for capillary gas chromatography

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