Development of chitosan/polyethylene vinyl acetate co-matrix: controlled release of aspirin-heparin for preventing cardiovascular thrombosis

Vasudev, Sindhu C.; Chandy, Thomas; Sharma, Chandra P.

doi:10.1016/s0142-9612(96)00131-7

Cited by 77 publications

(49 citation statements)

References 15 publications

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“…Microsphere formulations of these polymers have shown promising results in the delivery of many bioactive drugs and proteins (15,18,27). Chitosan, a naturally occurring polysaccharide, is widely used in biomedical applications and is capable of being processed under mild conditions (8,11,12,20). However, the development of a co-matrix system based on these polymers for delivering drug combinations has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…The studies with drug-loaded chitosan lms and beads proposed that the rate limiting step in drug release was diffusion through the polymer backbone absorbed with water rather than degradation of the polymer (11,13). A similar mechanism of heparin release from chitosan bead is possible in the present system.…”

Section: Discussionmentioning

confidence: 99%

“…Commonly used as biodegradable sutures (9), they have more recently contributed to reconstruction of de cient or injured organs and to improved galenic formulations (9,10). Chitosan, a natural polysaccharide having structural characteristics similar to glycosamino-glycans, seems to be nontoxic and bioabsorbable and has been explored for the release of several drugs (11,12).…”

mentioning

confidence: 99%

“…Heparin is widely used for a variety of important diseases including deep venous thrombosis, pulmonary emboli, unstable angina, myocardial infarction, and such cardiovascular interventions as bypass surgery and angioplasty (5,11,16). However, it is clear that the mode of heparin delivery is critical to its potential and it may well be that routine forms of administration are insuf cient to observe any bene t given the heparin's short half-life and complex pharmacokinetics.…”

mentioning

confidence: 99%

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Development of Poly(Lactic Acid)/Chitosan Co-Matrix Microspheres: Controlled Release of Taxol-Heparin for Preventing Restenosis

et al. 2001

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Development of Poly(Lactic Acid)/Chitosan Co-Matrix Microspheres: Controlled Release of Taxol-Heparin for Preventing Restenosis

et al. 2001

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“…At the same time, the compositions of chitosan with synthetic polymers are used as polymeric carriers; for example, a composite matrix of chitosan-poly(vinyl acetate) can be used as a carrier for aspirin-heparin drug system [50].…”

Section: Cellulose Chitin and Chitosan Blends With Synthetic Polymersmentioning

confidence: 99%

Polysaccharide-based polymer blends: Methods of their production

Роговина

Вихорева

2006

Glycoconj J

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The existing methods of preparing polymer blends of cellulose, chitin and chitosan with natural and synthetic polymers and their applications are reviewed. The methods of solid-phase blending of these polymers under conditions of joint action of high pressure and shear deformation are discussed. Normally, under these conditions the processes of dispersion of polymer particles, amorphization, mixing at different levels, depolymerization as well as a chemical interaction resulting in formation of branched and crosslinked structures can take place. The probability and intensity of these processes depend in many respects on the type and magnitude of the external force, but the properties of the polymers are of higher importance. The advantages of the method of joint action of high pressure and shear deformation compared to the conventional techniques of polysaccharides mixtures production are shown.

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Histopathological and immunohistochemical studies of membranes of deacetylated chitin derivatives implanted over rat calvaria

Hidaka

Ito

Mori

et al. 1999

J. Biomed. Mater. Res.

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Membranes made of 65, 70, 80, 94, and 100% deacetylated chitin (chitosan) were implanted subperiosteally over the calvaria of 100 rats. Reactions were studied at 1, 2, 4, and 8 weeks after implantation. Membranes prepared with 65, 70, and 80% deacetylated chitin initially elicited marked inflammatory reactions that subsided in time with granulation tissue formation and osteogenesis. Osteocalcin-positive cells were detected immunohistochemically in the granulation tissue. On the other hand, membranes made of 94% deacetylated chitin and chitosan showed mild inflammation and minimal osteogenesis. The results indicate that membranes made of 65, 70, and 80% deacetylated chitin enhance osteogenesis at the site of their implantation. However, the initially severe inflammatory reaction associated with these materials needs to be controlled before the materials would be suitable for clinical application.

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Development of chitosan/polyethylene vinyl acetate co-matrix: controlled release of aspirin-heparin for preventing cardiovascular thrombosis

Cited by 77 publications

References 15 publications

Development of Poly(Lactic Acid)/Chitosan Co-Matrix Microspheres: Controlled Release of Taxol-Heparin for Preventing Restenosis

Development of Poly(Lactic Acid)/Chitosan Co-Matrix Microspheres: Controlled Release of Taxol-Heparin for Preventing Restenosis

Polysaccharide-based polymer blends: Methods of their production

Histopathological and immunohistochemical studies of membranes of deacetylated chitin derivatives implanted over rat calvaria

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