Development of Extended Release Formulations of Ilaprazole Tablets

153

The presentation of this work aims to update professionals involved with aqueous film coating (AFC) of pharmaceuticals on facts associated with film coating (FC) based on aqueous solvent (AS). Initially sugar coating (SC) was the first choice of pharmaceutical industry and much time and efforts were spent in perfecting the techniques and processes of SC. Long processing time and demand for operator skill as in SC compelled them to develop FC. The FC of substrate is achieved by spraying solution of diverse polymer in AS or volatile organic solvent (VOS). Initially, use of VOS in the FC is preferred over AS, as latter inherits problems like sticking, picking, over-wetting, and many more. Momentum for using AS based FC and replacing the VOS based one with the aqua based one got accelerated from last few decade for reasons like safety, toxicity, stricter regulation on environmental pollution, and economy. Nowadays coating techniques & process relies mostly on AS due to its significant benefits over VOS. Functional properties of the film-coated pharmaceuticals depends greatly on film forming polymer (FFP) along with other factors like process, equipment, technology, additives, and many others. Summarised information on technical aspect of AFCs is rare, necessitating this work. Thus information gathered, summarised, studied, and hereby is attempting to be presented in a convenience way for enriching stakeholders in the pharmaceutical field. The presentation is for updating professionals in this regard. Key words: Aqueous, dispersion, film-coating, latex, polymer.

Section: True Dispersions/latexesmentioning

confidence: 99%

Section: Important Measures In Preparation Of True Dispersionsmentioning

confidence: 99%

Aqueous Film Coating the Current Trend

Saikh¹

2021

153

“…Aqueous dispersions based coating process are energy and time consuming reasoning from the low level of the film former (i.e., coating polymer) and large quantity of aqua that calls for evaporation [1][2][3][4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

“…Issues like cost and regulatory restrictions on use of volatile organic solvents, and energy and time requirement of aquasolvent based coating process had lead to developing specialised dry-coating techniques, over few decades [4][5][6][7][8][9][10][11][12] . These processes/ techniques find applicability in the coating of the dry powder particles 2,4,8,9 .…”

Section: Introductionmentioning

confidence: 99%

Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Alli¹

2021

608

Modification of surface attributes of particles, usually accomplished by coating, is desirous to enhance and maintain their usability. Coating is a multi-step process involves application of the coating material (CoM) onto the substrate, herein powder particles, where the process along with device/ equipment monitors surface attributes of the applied coating. Nowadays competitive market calls for cost cutting to survive product(s). Thus saving of energy and time, minimising number and quantity of additives, reducing and shortening process steps; consequently minimising the coating process cost are main goals while developing coating process for powder particle. Innovation of processes for dry-powder coating (DPC) along with their further development and refinement finds solution to said issues. Further, DPC process does not calls for liquid solvent or solution thus are viewed as cost-effective and environmentally safe, DPC process uses thermo-mechanical methods like mechanofusion, magnetic assisted impaction coating (MAIC), hybridization, rotating fluid-bed process, theta-composer, hot-melt coating (HMC), and many others. Besides these available are non-thermo-mechanical methods namely electrostatic coating; supercritical fluids (SCF) based methods like rapid expansion of supercritical fluid (RESF), gas anti-solvent (GAS), SCF anti-solvent, gas-saturated solution (GSS); vapour coating; and others. Basing on said thermo-mechanical and non-thermo-mechanical principle several DPC methods/ process had been reported in scientific literatures and patents. Said DPC method founds multidisciplinary applications like drug delivery and drug development. Diverse devices are there for the DPC process; their method of working, principle, limitations and benefits along with their applicability in pharmaceutical field are discussed and presented in this article. Keywords: Dry, particle, coating, pharmaceutical, process

“…Modifying surface attributes of FiUlFiPs via single-step, dry, thermo-mechanical method has been recognised as a potentially cheaper, simpler, safer, faster, and environmentfriendly approach comparing other processes that are dry or based on solvent [1][2][3]12 .…”

Section: Introductionmentioning

confidence: 99%

Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals

Saikh¹,

Mohapatra²

2021

189

The manuscript aims to provide glimpse on updated information relating thermo-mechanical dry coating processes (TMDCP) suiting in modifying surface attributes of fine and ultra-fine particle (FiUlFiP). FiUlFiPs are the integral component of pharmaceutical processes. They exhibit complex and queer properties, are conferred mostly from their surface attributes colligated with their higher surface area. Particle engineering technocrats extensively working for modifying surface & surface attributes of FiUlFiPs. These efforts are to find their worthy applications & new functionalities. Among available diverse particle engineering technologies/ process, TMDCP, a dry coating process (DCP), advocated being worthy and efficient. The TMDCP finds multidisciplinary applications, mostly in drug development & drug delivery. Said DCP involves fixing and/or attaching coating material (CoM) as particles herein synonym guest particle (GP) onto core/substrate particle (CSP) herein synonym host particle (HP). Attaching/ fixing the GPs onto HPs, in TMDCP, involve their mechanical and/or thermal interactions. Scientific literatures are evidencing diverse techniques and/or process, basing on discussed interactions. Amongst them novel techniques/ processes are Hybridization, Magnetically assisted impaction coating process (MAICP), Mechanofusion, Theta-composer, and high shear compaction. In this area diverse devices/ equipments are prevailing in market. Important are Hybridizer, Magnetically assisted impaction coater (MAIC), Theta-composer, Mechanofusion, Quadro Comil®, Cyclomix®, and many others. Attempt of this article is to discuss and present their method of working, working principle, applicability, limitations, and benefits. Contained information might be beneficial for professionals of pharmaceutical and allied field. Keywords: dry coating, equipment, particles, processes, thermo-mechanical.