Development of hydroxyapatite/calcium silicate composites addressed to the design of load-bearing bone scaffolds

Improvement of mechanical properties and biocompatibility of forsterite bioceramic addressed to bone tissue engineering materials

“…Hydroxyapatite (HA) is a significant success of bioceramics as a bone tissue repairing material. HA is osteoconductive; a property that promotes bone tissue growth (Sprio et al, 2009). Weak mechanical localized in the active areas of young bone.…”

Simultaneous mechanical property and biodegradation improvement of wollastonite bioceramic through magnesium dilute doping

“…Since Hench et al firstly discovered Bioglasss which was proved to possess excellent bioactivity and osteoconductivity in the early 1970s (Hench et al, 1971), Ca-silicate bioactive glasses, glass-ceramics, and bioceramics have been widely studied for their potential applications as hard tissue repair materials (De Aza et al, 2000;Gerhardt and Boccaccini, 2010;Kokubo et al, 1986;Sprio et al, 2009), special implants or prosthesis Vitale-Brovarone, 2014, 2015;Huhtinen et al, 2013), as well as drug delivery (Soundrapandian et al, 2014). For bone regeneration, the artificial materials need to meet the requirements of good osteoconduction, osteoinduction, as well as controllable bioactivity and degradation (Hench and Polak, 2002).…”

Composite Calcium Phosphate/Titania Scaffolds in Bone Tissue Engineering

“…On this basis, calcium silicate phases such as dicalcium and tricalcium silicate, as well as wollastonite or pseudo-wollastonite (CaSiO 3 ), were widely investigated as scaffolds or cements [34,35]. In particular, the development of composites made of HA reinforced with dicalcium silicate was investigated [36], on the basis of its high flexure strength (≈200 MPa) and reduced elastic modulus (≈40 GPa) [37], compared with HA, thus resulting as promising compositions for bone scaffolding. As a main drawback, calcium silicates exist in a variety of polymorphs stable in different conditions of temperature [38], thus making difficult to obtain pure phases and avoid decomposition detrimental for the mechanical properties.…”