Development of microbial resistant Carbopol nanocomposite hydrogels via a green process

Varaprasad, Kokkarachedu; Reddy, Goddeti Siva Mohan; Jayaramudu, J.; Sadiku, Rotimi; Ramam, Koduri; Ray, Suprakas Sinha

doi:10.1039/c3bm60185d

Cited by 25 publications

(19 citation statements)

References 28 publications

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“…[ 21 ] In a recent study, Varaprasad et al reduced Ag + ions using green reducing agent (mint leaf extract) in a Carbopol 980 NF and acrylamide gelation mixture to produce composite hydrogels for antibacterial applications. [ 22 ] In another recent example, Gema, M. et al utilized redox active catechol side chain in acrylamide-NIPAAm hydrogels to reduce gold precursor to nanoparticles to form nanoparticle-hydrogel composites that mimic mussel adhesive protein. [ 5 ] A schematic of this approach is presented in Figure 5 (b).…”

Section: Reactive Nanoparticle Formation Aided By the Hydrogel Networkmentioning

confidence: 99%

Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials

et al. 2015

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New technologies rely on the development of new materials, and these may simply be the innovative combination of known components. The structural combination of a polymer hydrogel network with a nanoparticle (metals, non‐metals, metal oxides, and polymeric moieties) holds the promise of providing superior functionality to the composite material with applications in diverse fields, including catalysis, electronics, bio‐sensing, drug delivery, nano‐medicine, and environmental remediation. This mixing may result in a synergistic property enhancement of each component: for example, the mechanical strength of the hydrogel and concomitantly decrease aggregation of the nanoparticles. These mutual benefits and the associated potential applications have seen a surge of interest in the past decade from multi‐disciplinary research groups. Recent advances in nanoparticle–hydrogel composites are herein reviewed with a focus on their synthesis, design, potential applications, and the inherent challenges accompanying these exciting materials.

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Section: Reactive Nanoparticle Formation Aided By the Hydrogel Networkmentioning

confidence: 99%

Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials

et al. 2015

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“…Chen et al ., developed thermosensitive carbopol hydrogels with good mechanical properties and release behaviour . Varaprasad et al ., prepared carbopol based nanocomposite hydrogels with antimicrobial activity …”

Section: Introductionmentioning

confidence: 99%

Dual release kinetics of antimalarials from soy protein isolate‐carbopol‐polyacrylamide based hydrogels

Aderibigbe

Mhlwatika

2016

J of Applied Polymer Sci

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The currently used antimalarials suffer from drug resistance which is hampering the global management of malaria infection. To overcome drug resistance, they are administered as combination therapies which involve combination of two or more antimalarials. In this study, chloroquine diphosphate and curcumin were encapsulated onto prepared soy protein isolate-carbopol-polyacrylamide based hydrogels. The hydrogels were pH sensitive and exhibited enhanced swelling capability at pH 7.4. The hydrogels were biodegradable which was observed by their SEM images after drug release. The release mechanisms of both drugs were influenced by the degree of crosslinking of the soy protein isolate in the hydrogel network and the presence of the other drug in the network. The release mechanisms of both drugs from the hydrogel networks followed super case transport II. These results suggested that the hydrogels were potential dual drug delivery systems for antimalarials whereby both drugs could work over different period of time and hence, have the potential to overcome drug resistance that is common with the presently used antimalarials. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43918.

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“…Among, dual inorganic nanomaterials are receiving increasing attention in biomedicine. Especially, silver, gold and their core/shell nanoparticles are have come into prominence since, they are nontoxic and biocompatible . Nevertheless, the difficulty occurs the difficulty occurs for the duration the preparation of the two individual nanoparticles within the polymer material, since they interact with each other and exceedingly agglomerated .…”

Section: Introductionmentioning

confidence: 99%

“…Especially, silver, gold and their core/shell nanoparticles are have come into prominence since, they are nontoxic and biocompatible . Nevertheless, the difficulty occurs the difficulty occurs for the duration the preparation of the two individual nanoparticles within the polymer material, since they interact with each other and exceedingly agglomerated . Owing to this phenomenon, most of the inorganic nanoparticles lose their individualities; which can reduce their applicability in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Development of microbial protective Kolliphor‐based nanocomposite hydrogels

Varaprasad¹,

Sadiku

2015

J of Applied Polymer Sci

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In this scientific work, a novel class of antimicrobial nanocomposite hydrogels were designed and synthesized by chemical and environmentally bioprocess using Kolliphor, acrylamide, and mint leafs in order to achieve antiseptic property for wound applications. In the bioprocess approach, silver nitrate and gold chloride were nucleated with mint leafs in order to obtain effective free individual nano-inorganic compounds to provide superior antibacterial assets. The formations of dual inorganic nanoparticles were confirmed by transmission electron microscopy, which indicated the size of nanoparticles in the range of approximately 3 6 2 nm and without agglomeration. The formations of biomaterials were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopic-energy dispersive spectrometric studies and their swelling properties were determined. Furthermore, the pure hydrogel and the dual inorganic nanocomposite hydrogels developed were tested for antibacterial activities. When compared with the neat hydrogel, the nanocomposite hydrogels significantly improved their anti-bacterial activities on Bacillus bacterium.

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Development of microbial resistant Carbopol nanocomposite hydrogels via a green process

Cited by 25 publications

References 28 publications

Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials

Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials

Dual release kinetics of antimalarials from soy protein isolate‐carbopol‐polyacrylamide based hydrogels

Development of microbial protective Kolliphor‐based nanocomposite hydrogels

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