Diabetes mellitus and the heart

Abstract

Summary Diabetes mellitus is a risk factor for the development of coronary artery disease and chronic heart failure. When carefully screened for, diabetes or prediabetic disorders, are present in the majority of patients with clinically manifest ischaemic heart disease, and confer a major adverse impact upon morbidity and mortality. Important therapeutic modifications are required in the management of coronary artery disease and chronic heart failure associated with diabetes, and vice versa. However, despite optimal management, aided by recent landmark trials solely recruiting patients with diabetes, outcomes for patients with diabetes and heart disease remain poor. This review outlines the epidemiology, pathogenesis and management of diabetic heart disease, along with highlighting the many gaps in the evidence‐base and suggesting future research priorities.

Pre-transplant diabetes mellitus is a risk factor for non-relapse mortality, especially infection-related mortality, after allogeneic hematopoietic SCT

“…This finding was consistent with previous reports. [25][26][27][28][29][30] However, pre-transplant DM was an independent risk factor of NRM in a multivariate analysis that included all other HCT-CI factors. Furthermore, when patients were stratified according to the HCT-CI score that did not include DM, the incidence of NRM in patients with DM was higher than that in those without DM.…”

Anti-Oxidative, Anti-Hyperglycemic and Lipid-Lowering Effects of Aqueous Extracts of <i>Ocimum sanctum</i> L. Leaves in Diabetic Rats

“…However, diabetes impairs not only the liver and kidney but also the heart [19]. Diabetes has a high relevance with cardiovascular diseases including hypertension and ischemic heart disease [20]. Since our previous study showed that OS leaf powder in the diet reduced blood glucose and serum marker enzymes of liver and kidney function in streptozotocin-induced DM rats [9].…”

Left Ventricular Mechanics in Untreated Normotensive Patients with Type 2 Diabetes Mellitus: A Two‐ and Three‐dimensional Speckle Tracking Study

“…Type 2 diabetes mellitus (DM), together with arterial hypertension, obesity, dyslipidemia and smoking, represents one of the most prevalent cardio‐ and cerebrovascular risk factors . At the same time, DM is one of the most important risk factors of cardiac remodeling .…”