Diabetic cachectic neuropathy: An uncommon neurological complication of diabetes

Iyagba, Alagoma; Onwuchekwa, Arthur

doi:10.7196/samj.2017.v106i12.11198

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…4 Diabetic neurological complication is one of the most common chronic complications of diabetes. 5 In recent years, the incidence of diabetic central nervous system complications (CNS) with mild-tomoderate cognitive impairment has increased. 6 Hippocampus is the main structure of short-term memory loop, which plays an important role in the transition from short-term memory to long-term memory.…”

Section: Introductionmentioning

confidence: 99%

Retracted:MicroRNA‐219 decreases hippocampal long‐term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing theNMDARsignaling pathway

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Retracted:MicroRNA‐219 decreases hippocampal long‐term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing theNMDARsignaling pathway

et al. 2018

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“…Few cases of diabetic neuropathic cachexia have been reported so far. Using a MEDLINE search using diabetic neuropathic cachexia and acute painful neuropathy cachexia as key words, only 15 articles and 31 case reports of this DN rare variant were detected [ 1 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Table 1 summarizes the clinical aspects of cases described so far.…”

Section: Discussionmentioning

confidence: 99%

Diabetic Neuropathic Cachexia: A Clinical Case and Review of Literature

Bellelli

Santi

Simoni

et al. 2022

Life

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A 46-year-old man was admitted to the surgical department because of abdominal pain and anemia, with the radiological finding of a perforated duodenal ulcer, and underwent laparoscopic surgical treatment. Type 2 diabetes mellitus (T2DM) had been diagnosed 5 years earlier and treated with diet. At clinical investigation, the patient was depressed and anorexic; moreover, he complained of lower extremity weakness and bilateral feet pain, burning in nature and accompanied by allodynia. This painful sensation had been preceded by an 8-month history of fatigue and anorexia with profound weight loss of 35 kg. After clinical evaluation and a nerve conduction study, diagnosis of diabetic cachectic neuropathy was made based on the rapid onset of severe neuropathic pain in the context of diabetic neuropathy, marked weight loss, and depressed mood. The therapy with pregabalin and duloxetine had scarce effect and was gradually discontinued. The patient, however, obtained progressive relief and amelioration of neuropathic lower-limb pain concomitant with weight gain. This clinical trend also confirmed the diagnosis of this rare form of diabetic neuropathy. A few cases of diabetic neuropathic cachexia have been reported in the literature and are briefly reviewed here.

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“…The International Diabetes Federation (IDF) reported, in 2021, that 537 million adults aged 20–79 years are currently living with DM, which represents 10.5% of the world’s population in this age group, with Africa being the part of the world where more than half the people with DM are undiagnosed ( 2 ). About 80% of diabetic patients live in low- and middle-income countries and almost 4 million people die of diabetes and its complications, with half of these people below the age of 60 years ( 1 – 3 ). The incidence of diabetic complications is expected to increase, and about 6.7 million adults are estimated to have died as a result of DM or its complications in 2021 ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and grade of diabetic peripheral neuropathy among known diabetic patients in rural Uganda

Munyambalu

Hildago²,

Bafwa³

et al. 2023

Front. Clin. Diabetes Healthc.

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BackgroundDiabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). Approximately 50% of diabetic patients are estimated to develop DPN, depending on disease duration and diabetic control. Early diagnosis of DPN will avoid complications, including non-traumatic lower limb amputation, which is considered the most debilitating complication, as well as significant psychological, social, and economical problems. There is a paucity of literature on DPN from rural Uganda. This study aimed to deliver the prevalence and grade of DPN among DM patients in rural Uganda.MethodsA cross-sectional study that recruited 319 known DM patients was conducted in an outpatient clinic and a diabetic clinic at Kampala International University-Teaching Hospital (KIU-TH), Bushenyi, Uganda, between December 2019 and March 2020. Questionnaires were used to obtain clinical and sociodemographic data, a neurological examination was carried out to assess the DPN, and a blood sample was collected from each participant (for random/fasting blood glucose and glycosylated hemoglobin analyses). Data were analyzed using Stata version 15.0.ResultsThe sample size was 319 participants. The mean age of study participants was 59.4 ± 14.6 years and there were 197 (61.8%) females. The prevalence of DPN was 65.8% (210/319) (95% CI 60.4% to 70.9%), and 44.8% of participants had mild DPN, 42.4% had moderate DPN, and 12.8% had severe DPN.ConclusionThe prevalence of DPN at KIU-TH was higher among DM patients and its stage might have a negative impact on the progression of Diabetes Mellitus. Therefore, clinicians should consider neurological examination as a routine during assessment of all DM patients especially in rural areas where resources and facilities are often limited so that complications related to Diabetic mellitus will be prevented.

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Diabetic cachectic neuropathy: An uncommon neurological complication of diabetes

Abstract: This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

Cited by 3 publications

References 6 publications

Retracted:MicroRNA‐219 decreases hippocampal long‐term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing theNMDARsignaling pathway

Retracted:MicroRNA‐219 decreases hippocampal long‐term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing theNMDARsignaling pathway

Diabetic Neuropathic Cachexia: A Clinical Case and Review of Literature

Prevalence and grade of diabetic peripheral neuropathy among known diabetic patients in rural Uganda

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