Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice

Malaguti, Carina; Vilella, Conceição Aparecida; Vieira, Karla Priscila; Souza, Gustavo H. M. F.; Hyslop, Stephen; Zollner, Ricardo de Lima

doi:10.1016/j.intimp.2008.01.020

Cited by 44 publications

(43 citation statements)

References 49 publications

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“…Rhein, one of the major bioactive constituents of the rhizome of rhubarb (Rheum palmatum Linn. or R. tanguticum Maxim), is a widely used traditional Chinese herb with broad pharmacological effects, including antidiabetic activity (22,23), anti-inflammation and inhibition of interleukin-1-induced chondrocyte activation (24). However, due to its water insolubility, the efficacy of rhein is limited in vivo.…”

Section: Introductionmentioning

confidence: 99%

Effects of rhein lysinate on D-galactose-induced aging mice

Zhen

Lin

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the anti-aging effects of rhein lysinate (RHL), and to explore its mechanism of action in a D-galactose-induced aging mouse model. Aging was induced by D-galactose (100 mg/kg/day) that was subcutaneously injected to animals for 8 weeks. RHL was simultaneously administered once a day by intragastric gavage. The appetite, mental condition, body weight and organ index of the mice were monitored. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined, and the levels of malondialdehyde (MDA) in the liver, kidney and serum were measured by appropriate assay kits. Western blot analysis was used to detect proteins associated with age. The results indicated that RHL may improve the appetite, mental state and organ conditions of the model mice, improve the activities of SOD and GSH-Px, reduce MDA levels and modulate the expression of age-associated proteins (Sirtuin 1, p21 and p16) in D-galactose-induced mice. Therefore, RHL may be effective at suppressing the aging process through a combination of enhancing antioxidant activity, scavenging free radicals and modulating aging-associated gene expression.

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Section: Introductionmentioning

confidence: 99%

Effects of rhein lysinate on D-galactose-induced aging mice

Zhen

Lin

et al. 2015

Experimental and Therapeutic Medicine

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“…31 It downregulates pro-inflammatory cytokine expression (interleukin-1-beta (IL-1b), IL-12 and TNF-alpha). 32 In this study, the animals that received 50 mg/kg of oral diacerein daily from the third to the seventh postoperative month showed the best results on all slides (femur and tibia bilaterally, whether operated on or not). There was no difference between the findings seven months after surgery in the group that received daily doses of diacerein and the group that was sacrificed three These results were not affected by the animal's weight.…”

Section: Discussionmentioning

confidence: 59%

Experimental osteoarthritis model by means of medial meniscectomy in rats and effects of diacerein administration and hyaluronic acid injection

et al. 2014

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CONTEXT AND OBJECTIVE: The development of a slow and progressive mechanical model for osteoarthritis is important for correlation with clinical practice, and for evaluating the effects of disease-modifying medications. A mechanical osteoarthritis model was developed to evaluate the effects of intra-articular hyaluronic acid (HA) injection and oral diacerein administration. DESIGN AND SETTING: Experimental study at the Department of Orthopedics and Traumatology, Universidade de São Paulo. METHOD: Total medial meniscectomy was performed on seven groups of ten Wistar rats each, comprising four control groups (C) and three study groups (S). C.I: operated, non-medicated; C.II: operated, injections of HA vehicle; C.III: non-operated, non-medicated; C.IV: operated, non-medicated, sacrificed three months post-meniscectomy; S.I: operated, receiving intra-articular HA injections; S.II: operated, oral diacerein from the third to the seventh postoperative month; S.III: operated, received both medications. All the animals (except C.IV) were sacrificed seven months post-meniscectomy. All femurs and tibias were assessed histologically. RESULTS: The most severe degenerative histological changes were in the tibias of the operated knees. On the contralateral side, all groups had mild changes on the tibial surface. The femoral surface had slight changes. C.I showed severe changes. S.II results matched those of C.IV. HA protected the tibial surface. S.II and S.III had similar results. CONCLUSIONS: 1) The experimental model produced mild arthritis after three months and severe arthritis after seven months; 2) diacerein reduced the degenerative changes in both knees; 3) HA protected the joint cartilage; 4) Combining the two drugs did not improve the results.RESUMO CONTEXTO E OBJETIVO: Desenvolver um modelo osteoartrítico mecânico lento e progressivo é importante para correlação com a prática clínica e para avaliar os efeitos de medicamentos modificadores da doença. Um modelo mecânico de osteartrite foi desenvolvido para avaliar os efeitos de injeção intra-articular de hialuronato de sódio (AH) e de administração de diacereína oral. DESENHO E LOCAL: Estudo experimental no Departamento de Ortopedia e Traumatologia, Universidade de São Paulo. MÉTODO: Meniscectomia medial total foi feita em sete grupos de dez ratos Wistar, sendo quatro grupos controle (C) e três grupos estudo (E). C.I: operado, não medicado; C.II: operado, recebendo injeções do veículo do AH; C.III: não operado, não medicado; C.IV: operado, não medicado, sacrificado três meses pós-meniscectomia; EI: operado, recebendo injeções de AH intra-articular; E.II: operado, recebendo diacereína oral do terceiro ao sétimo mês pós-operatório; E.III: operado, recebeu ambas medicações. Todos os animais (exceto C.IV) foram sacrificados sete meses pós-meniscectomia. Todos os fêmures e tíbias foram analisados histologicamente. RESULTADOS: As alterações histológicas degenerativas mais graves encontram-se nas tíbias dos joelhos operados. No lado contra-lateral, todos os grupos apre...

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“…На моделях животных было показано, что диацереин способствует увеличению количества b-клеток в поджелудочной желе-зе и их выживаемости, а также нормализует секрецию инсулина [35,36]. Кроме того, повышает чувствительность периферических тканей к инсулину (особенно в печени и жировой ткани) [33], улучшает толерантность к глюкозе и снижает уровень гликемии натощак [33,[35][36][37].…”

Section: Discussionunclassified

New Opportunities Therapy in Patients With Knee Joint Osteoarthritis and Metabolic Syndrome

Алексеева¹,

Таскина²,

Кашеварова³

et al. 2018

Med. sov.

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5-10 years). Duration of the study was 9 months (6 months of therapy: 1 capsule (50 mg) per day for the first month, 2 capsules (100 mg) per day for the next 5 months, and follow-up for 3 months). Evaluation of the efficacy and safety of the treatment was conducted according to generally accepted criteria. All patients were underwent biochemical tests at the beginning and at the end of therapy. Results. The study resulted in a statistically significant reduction in pain when walking according to VAS as early as in 1 month from the beginning of treatment; the further significant improvement was observed during the entire 6-month therapy. Withdrawal of therapy (the observation period was 3 months) didn't increase the pain syndrome. Evaluation according to Womac index also revealed identical regularity. A statistically significant improvement in the quality of life according to EQ-5D was also identified during the whole period of observation. By the end of the therapy, 92.5% of the patients were OMERACT -OARSI -responders and 64.2% of patients had completely withdrawn from NSAID. Against the background of the therapy, there was a significant decrease in BMI, LDL, TG, glucose, uric acid levels. Conclusion: The data obtained make it possible to recommend diacerein as a basic therapy for OA in patients with MS. On the background of therapy, the patients showed statistically significantly reduction in pain, stiffness, the need for NSAIDs, improved the quality of life and the function of the joints. In addition, the body weight decreases reliably, the lipidogram, carbohydrate and protein metabolism parameters also improved.

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Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice

Cited by 44 publications

References 49 publications

Effects of rhein lysinate on D-galactose-induced aging mice

Effects of rhein lysinate on D-galactose-induced aging mice

Experimental osteoarthritis model by means of medial meniscectomy in rats and effects of diacerein administration and hyaluronic acid injection

New Opportunities Therapy in Patients With Knee Joint Osteoarthritis and Metabolic Syndrome

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