Diagnostic value of neutrophil-lymphocyte ratio versus C-reactive protein in discrimination between different pathogens causing community-acquired pneumonia

Elemshaty, Wafaa; Mashaly, Mervat; Moawad, Amr; EL-Gamal,, M.; Hewidy, Asem A.

doi:10.1007/s00580-017-2443-1

Cited by 7 publications

(12 citation statements)

References 23 publications

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“…Regarding NLR, several reports have determined its diagnostic value for bacterial infections. Among them, Ahn et al [15] demonstrated that NLR has a higher diagnostic value than CRP and neutrophils for pneumonia in 523 patients with heart failure; this reinforced by El-Emshaty et al [16], who determined that NLR is a marker that can differentiate, even with greater precision than CRP, atypical bacterial pneumonia in 187 patients.…”

Section: N Resultsmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio and mean platelet volume in the diagnosis of bacterial infections in COVID-19 patients. A preliminary analysis from Ecuador

et al. 2021

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Hospitalized COVID-19 patients are at risk of hospital infection. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-C-reactive protein ratio (LCR) and mean platelet volume (MPV) are established inflammation markers reflecting the systemic inflammatory response. The objective of this study was to evaluate the clinical characteristics of patients with COVID-19 and bacterial co-infections, as well as the correlation with NLR and MPV. Methods: We assessed the role of the NLR and MPV in diagnosing bacterial infections in COVID-19 patients. The Wilcoxon test was used to compare the mean NLR and MPV between the diagnostic evaluation moments, while the Mann-Whitney test was used to compare NLR and MPV by sex and age. Results: The NLR was compared three days before the culture and the day of taking the culture, observing SUMMARY significant differences (p=0.020). MPV three days before the culture and the day of the culture were compared, also observing significant differences (p=0.031). NLR and MPV were compared at the different evaluation times according to sex and age group, observing for the age group significant differences for the NLR three days before the culture (p=0.004). Conclusion: In our study, there were significant differences in NLR and MPV between the three days before culture and the day of culture. It is advisable to continue to enrol more patients in the study so that in the future, we can add results on the diagnostic accuracy of the NLR and MPV in the timely diagnosis of bacterial infection in patients with COVID-19.

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Section: N Resultsmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio and mean platelet volume in the diagnosis of bacterial infections in COVID-19 patients. A preliminary analysis from Ecuador

et al. 2021

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“…Community-acquired pneumonia is the main cause of infectious disease-related mortality worldwide and is responsible for approximately 1 million hospital admissions with a great impact on health care resources. Its incidence and mortality are related to the increase in age and the presence of comorbidities (4). Given that the population is aging, it is expected that CAP will continue increasing as an outstanding public health problem (6).…”

Section: Cap Epidemiologymentioning

confidence: 99%

“…Community-acquired pneumonia can be caused by many microorganisms including fungi, viruses, and bacteria; thus, it is essential to determine the pathogenic microorganism that causes the infection to provide an adequate clinical diagnosis (4). The most common pathogen causing CAP is Streptococcus pneumoniae, but nearly 50% of patients with CAP still have unidentified organisms (5).…”

Section: Introductionmentioning

confidence: 99%

Community-Acquired Pneumonia in Adults: What’s New Focusing on Epidemiology, Microorganisms and Diagnosis?

Romero¹,

Rello²

2018

Erciyes Med J

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Community-acquired pneumonia (CAP) is one of the most common causes of hospital admissions and death worldwide. The incidence and mortality of CAP are associated with the presence of comorbidities and increasing age. Streptococcus pneumoniae is the most frequent causative microorganism of CAP, although in many patients with CAP, the causative microorganism remains unknown. Currently, antimicrobial resistance is increasing, so the accurate diagnosis and determination of the causative microorganism are even more important. This is a key point in reducing both morbidity and mortality from CAP, and appropriate antimicrobial stewardship is now a global priority. This review summarizes on the epidemiology, microbiological etiology, and diagnosis of CAP in adults.

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“…The NLR has been found to be a useful laboratory marker for differentiating pulmonary TB from bacterial CAP at the initial diagnostic stage in adults by some authors. 9,10 The NLR can be determined by dividing the absolute count of neutrophils by the number of lymphocytes in the complete blood count. The value of NLR has been studied in cardiovascular disease, chronic renal disease, malignancies, osteoporosis and Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

“…The NLR can also be used to determine the severity of both pulmonary TB and pneumonia & can also guide us towards the management of the patient. 10,[20][21][22] In this study, we aim to assess the role of NLR as a possible marker in differentiating pulmonary TB from CAP.…”

Section: Introductionmentioning

confidence: 99%

Role of neutrophil-lymphocyte ratio as a potential marker to differentiate between pulmonary tuberculosis and community-acquired pneumonia in children

Mosleh

Das²,

Mutanabbi³

2022

Int J Contemp Pediatr

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Background: This is often creating challenge to differentiate pulmonary tuberculosis (TB) with community acquired pneumonia (CAP) particularly in children. The neutrophil-lymphocyte count ratio (NLR) as an indicator of inflammation has been used in various infectious diseases. The aim of this study was to investigate the role of NLR as a possible marker in differentiating pulmonary TB from CAP.Methods: In this retrospective record based analytic study, conducted from July 2020 to Dec 2021, patient aged 2 months to 18 years diagnosed as pulmonary TB or CAP were enrolled in this study i.e., 155 children after exclusion. The diagnostic ability of NLR in differentiating between pulmonary Tb and CAP were assessed.Results: Out of 155 children, 85 (54.8%) had CAP and 70 (45.1%) had pulmonary TB. Mean values of NLR were significantly lower in patients with TB than in pneumonia (3.16±1.9 vs 5.05±1.2, p<0.000). Total WBC, neutrophil, Hb and CRP were also significantly lower in patients with pulmonary TB. On the other hand, lymphocyte count was significantly higher in children with pulmonary TB in compare to children with pneumonia (p=0.04).Conclusions: The NLR can be used as a useful simple laboratory marker in differentiating children with Pulmonary TB from CAP, especially in resource limited high TB disease burden countries.

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Diagnostic value of neutrophil-lymphocyte ratio versus C-reactive protein in discrimination between different pathogens causing community-acquired pneumonia

Cited by 7 publications

References 23 publications

Neutrophil-to-lymphocyte ratio and mean platelet volume in the diagnosis of bacterial infections in COVID-19 patients. A preliminary analysis from Ecuador

Neutrophil-to-lymphocyte ratio and mean platelet volume in the diagnosis of bacterial infections in COVID-19 patients. A preliminary analysis from Ecuador

Community-Acquired Pneumonia in Adults: What’s New Focusing on Epidemiology, Microorganisms and Diagnosis?

Role of neutrophil-lymphocyte ratio as a potential marker to differentiate between pulmonary tuberculosis and community-acquired pneumonia in children

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