Differences in the prevalence and characteristics of metabolic syndrome in rheumatoid arthritis and osteoarthritis: a multicentric study

Šalamon, Lea; Morović‐Vergles, Jadranka; Marasović-Krstulović, Daniela; Kehler, Tatjana; Šakić, Davorin; Badovinac, Olga; Vlak, Tonko; Novak, Srđan; Štiglić-Rogoznica, Nives; Hanih, Marino; Bedeković, Dražen; Grazio, Simeon; Kadojić, Mira; Prus, Višnja; Stamenković, Doris; Šošo, Daniela; Anić, Branimir; Babić-Naglić, Đurđica; Gamulin, Stjepan

doi:10.1007/s00296-015-3307-0

Cited by 19 publications

(7 citation statements)

References 48 publications

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“…Previous studies have shown that MetS patients have higher CRP and ESR levels than nMetS patients, 35,36 and MetS-OA patients have higher expression levels of CRP and ESR than nMetS-OA patients. 21 These previous studies are in line with the present findings. Moreover, many studies have demonstrated that adipokines participate in the pathological process of KOA by regulating inflammation, cartilage metabolism, and chondrocyte death.…”

Section: Discussionsupporting

confidence: 93%

“…[18][19][20] Šalamon et al demonstrated that the prevalence of MetS in patients with OA was 1.6-times higher than that in patients with rheumatoid arthritis, and patients with MetS-OA had higher expression levels of CRP and ESR than those of the nMetS-OA group. 21 Bello-Chavolla and colleagues proposed the metabolic score for insulin resistance (METS-IR) in 2018, 22,23 which was established based on certain metabolic indicators in MetS. METS-IR is highly correlated with body fat content, 22 and can be used to quantify the degree of metabolic abnormalities in a subject while evaluating insulin resistance (IR).…”

Section: Introductionmentioning

confidence: 99%

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<p>Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population</p>

Ding¹,

Gao²,

Li³

et al. 2020

DMSO

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Purpose: This study was to evaluate the metabolic score for insulin resistance (METS-IR) in female knee osteoarthritis (KOA) patients in a Chinese population. The associations between METS-IR and adipokines, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were investigated. Patients and Methods: This study included 4686 women from the 2011 China Health and Retirement Longitudinal Study (CHARLS) and 108 women who underwent arthroplasty of KOA at a university hospital. The clinical data were collected, and adipokines were evaluated. METS-IR was calculated in the KOA patients and compared with the national baseline. Logistic regression analyses were applied to explore the associations of METS-IR with adipokines, ESR, and CRP. Results: Receiver operating characteristic curve analysis of METS-IR and metabolic syndrome (MetS) in national baseline showed an area under the curve value of 0.851, with sensitivity of 0.777 and specificity of 0.772. The METS-IR of KOA was higher than the national baseline level (40.29 ± 6.98 vs 36.20 ± 8.50, P < 0.01), even after adjusting age. In addition, the METS-IR was higher in patients with KOA who had MetS than in those without metabolic syndrome (nMetS), even after adjusting body mass index (BMI). After adjusting for age and BMI, METS-IR was associated with CRP (

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

<p>Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population</p>

Ding¹,

Gao²,

Li³

et al. 2020

DMSO

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“…Different investigations have been carried out around the association that might exist between gonarthrosis and MS, but there are still no solid evidences of an association between both conditions 20 . In this study, although strict criteria were used to classify patients as MS carriers 21 , its prevalence in patients with and without gonarthrosis was 79.9% and 59%, respectively, with these figures being higher than in other reports 3,22,23 , possibly because those studies were carried out with larger populations and in variable age groups and, in contrast, this investigation had a large proportion of advanced-age participants. Numerous factors that can influence on the occurrence of gonarthrosis and other types of arthrosis, such as gender, diabetes mellitus, high blood pressure and body mass index, have been studied, but until recently, MS as a whole had not been exhaustively investigated as a possible associated factor 5,12,24,25 .…”

Section: Discussioncontrasting

confidence: 67%

Metabolic syndrome and other factors associated to gonarthrosis

Charles-Lozoya¹,

Treviño-Báez²,

Ramos-Rivera³

et al. 2023

GMM

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Objective: To evaluate whether an association exists between gonarthrosis and metabolic syndrome X (MS) as well as other potential risk factors. Method: Comparative cross-sectional study of 310 patients evaluated by pathology of knee grouped in patients with gonarthrosis and without it. Sociodemographic, anthropometric and laboratory data was obtained. Gonarthrosis was defined as a ≥ score in Kellgren-Lawrence radiological scale, and MS was assessed using the International Diabetes Federation criteria. Odds ratio and logistic regression were used for bivariate and multivariate analysis respectively. Results: The prevalence of MS in patients who had gonarthrosis was 79.9%, statistically higher than in patients without gonarthrosis (p = 0.001). Other factors that had a statistically higher frequency in this group included diabetes mellitus (p = 0.02) and hypertension (p = 0.02). Multivariate analysis revealed MS had an association with a higher prevalence of gonarthrosis (p = 0.003), while high density lipoproteins (p = 0.02) was associated with a lower prevalence. Conclusions: MS and its related alterations are associated to gonarthrosis; their adequate control could prevent patients from developing the disease.

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“…Various inflammation biomarkers have been measured in patients with MetS, of which CRP is the most well-characterized ( 55 , 56 ). Evidence has shown that CRP levels are elevated in patients with MetS in both the general population ( 57 , 58 ) and patients with RMDs, such as SLE ( 30 , 59 , 60 ) and RA ( 61 , 62 ). Accordingly, our results in APS showed that an increase in CRP levels is independently associated with MetS presence, using JIS and IDF diagnostic criteria.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome in antiphospholipid syndrome versus rheumatoid arthritis and diabetes mellitus: Association with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and coronary atherosclerotic plaques

Bolla

Tentolouris²,

Sfikakis³

et al. 2023

Front. Immunol.

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BackgroundCardiovascular disease (CVD) is the foremost cause of morbidity and deaths in antiphospholipid syndrome (APS), driven by thrombo-inflammation and atherothrombosis mechanisms. Metabolic syndrome (MetS) is a proinflammatory and prothrombotic state characterized by increased CVD risk. We aimed to evaluate the prevalence of MetS in APS patients compared to rheumatoid arthritis (RA) and diabetes mellitus (DM) and its associations with clinical and laboratory patient characteristics and vascular ultrasound (US) markers of subclinical atherosclerosis.MethodsWe included 414 patients in our study: 138 patients with APS (median age: 44.9 years, females 70%) and matched 1:1 for age and sex RA and DM subjects. Three sets of criteria were used for MetS diagnosis: Joint Interim Statement (JIS), International Diabetes Federation (IDF) and modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). The demographic, clinical and laboratory characteristics of all participants were recorded and carotid and femoral US was performed in patients with APS. Multivariate regression models were applied.ResultsPrevalence of MetS was 23.9%, 23.2%, 20.3% (based on JIS, IDF, modified NCEP-ATPIII criteria, respectively) in APS versus 17.4%, 17.4%, 13% in RA (p=0.181, p=0.231, p=0.106, respectively), and 44.2%, 44.2%, 40.6% in DM patients. In multivariate analysis, patients with systemic lupus erythematosus- related APS had an approximately 2.5-fold higher risk of MetS versus RA patients. MetS in APS was independently associated with arterial thrombosis (Odds ratio 3.5, p=0.030). Odds ratio for MetS was 1.16 for each one unit increase in C-reactive protein levels according to JIS and IDF criteria, and 1.49 and 1.47 for each one unit increase in uric acid levels using the IDF and modified NCEP-ATPIII models, respectively. APS patients with atherosclerotic carotid plaques had 4 to 6.5-fold increased risk of MetS. Odds for MetS were decreased by 26% with an increase in physical activity by one hour per week.ConclusionsMetS is present in approximately one-fourth of APS patients at a comparable prevalence to that observed in patients with RA. MetS in APS is associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis, supporting its role in cardiovascular risk stratification and management in APS.

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Differences in the prevalence and characteristics of metabolic syndrome in rheumatoid arthritis and osteoarthritis: a multicentric study

Cited by 19 publications

References 48 publications

<p>Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population</p>

<p>Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population</p>

Metabolic syndrome and other factors associated to gonarthrosis

Metabolic syndrome in antiphospholipid syndrome versus rheumatoid arthritis and diabetes mellitus: Association with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and coronary atherosclerotic plaques

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