Metabolic syndrome and other factors associated to gonarthrosis

Abstract

Objective: To evaluate whether an association exists between gonarthrosis and metabolic syndrome X (MS) as well as other potential risk factors. Method: Comparative cross-sectional study of 310 patients evaluated by pathology of knee grouped in patients with gonarthrosis and without it. Sociodemographic, anthropometric and laboratory data was obtained. Gonarthrosis was defined as a ≥ score in Kellgren-Lawrence radiological scale, and MS was assessed using the International Diabetes Federation criteria. Odds ratio and logistic regression were used for bivariate and multivariate analysis respectively. Results: The prevalence of MS in patients who had gonarthrosis was 79.9%, statistically higher than in patients without gonarthrosis (p = 0.001). Other factors that had a statistically higher frequency in this group included diabetes mellitus (p = 0.02) and hypertension (p = 0.02). Multivariate analysis revealed MS had an association with a higher prevalence of gonarthrosis (p = 0.003), while high density lipoproteins (p = 0.02) was associated with a lower prevalence. Conclusions: MS and its related alterations are associated to gonarthrosis; their adequate control could prevent patients from developing the disease.

Gonartrozlu Hastalarda Trigliserit Glikoz İndeksi ile Nötrofil Lenfosit Oranı Arasındaki İlişki

“…Health Study, obese women with two or more cardiovascular disease risk factors reported knee pain in the past three years. 12 In the Japanese ROAD study, the risk of osteoarthritis increased with the presence of each component of the metabolic syndrome. 13 In addition, in a study in Russia with the presence of 1,350 people with osteoarthritis, 56.62% had metabolic syndrome.…”

“…14 Also, other studies have discussed the relationship between the components of metabolic syndrome and osteoarthritis. 12,13,15 Arthritis and obesity have been known to be related to each other in many studies. [14][15][16] Although the exact association mechanism between obesity and arthritis is unknown, studies report metabolic mechanical factors in this relationship.…”

“…22,23 Moreover, the results of the studies indicate that the increase in oxidative stress plays a signi cant role in causing diseases related to metabolic syndromes, such as atherosclerosis, high blood pressure, and type 2 diabetes. 24 Oxidative stress has also been associated with obesity and insulin resistance in men 12 and metabolic syndrome in American adults. 14 Several studies indicate that metabolic syndrome can be considered a pre-oxidative condition.…”