Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology

Abstract

The optimized methodical approach reported here not only allows to determine area-specific gene expression profiles of intraindividually different low-RNA containing OA cartilage specimens. In addition, this study also revealed novel genes not yet reported to play a role in the pathophysiology of joint destruction in OA.

The multiple facets of periostin in bone metabolism

“…These observations are consistent with the inhibition of periostin expression by inorganic phosphate as described previously [29]. Finally, it is of interest to report the expression of periostin in fibroblast-like synoviocytes from rheumatoid arthritis [30] and in cartilage biopsies from osteoarthritis patients [31].…”

Involvement of Angiopoietin-like 4 in Matrix Remodeling during Chondrogenic Differentiation of Mesenchymal Stem Cells

“…Also, transcriptomic data obtained by Geyer and colleagues have shown that ANGPTL4 is up-regulated in damaged cartilage of a subset of osteoarthritic patients (see supplementary data in Ref. 40). In addition, ANGPTL4 was shown to stimulate osteoclast-mediated bone resorption (41).…”

Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

“…To date, such comparisons are few and often limited in terms of using small data sets or reliant on animal models 12e17 , although several studies have examined gene expression changes between damaged and intact cartilage within the same knee joint of OA patients 13,16 . One of the first studies to compare human normal vs OA cartilage identified a decrease in expression of important oxidative defence genes especially SOD2 and SOD3 18 , a finding we recently verified 19 .…”