Differentially regulated production of platelet-derived growth factor and of transforming growth factor beta by a human teratocarcinoma cell line

Weima, Sjerp M.; Rooijen, Marga A. van; Mummery, Christine L.; Feijen, A.; Kruijer, W.; Laat, Siegfried W. de; Zoelen, E.J.J. van

doi:10.1111/j.1432-0436.1988.tb00214.x

Cited by 17 publications

(10 citation statements)

References 46 publications

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“…Human: Jurkat (Weiss, 1984), T cell leukaemia; Nalm-6 (Minowada et al, 1978), pre-B cell acute lymphoblastic leukaemia; Daudi (Klein et al, 1968), Burkitt's lymphoma; K562 (Lozzio and Lozzio, 1975), chronic myelogenous leukaemia; KG1 (Koeer and Golde, 1978), acute myelogenous leukaemia; HL-60 (Collins et al, 1977), acute myeloid leukaemia; APL (Chen et al, 1992), acute promyelocytic lukaemia bone marrow cells; 293 (Graham et al, 1977), adenovirus transformed human embryo kidney cells; HSG (Shirasuna et al, 1981), salivary gland adenocarcinoma; T 2 Cl 13 (Weima et al, 1988), teratocarcinoma cells; T47D (Keydar et al, 1979), breast carcinoma.…”

Section: Human and Mouse Cell Linesmentioning

confidence: 99%

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

et al. 1999

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BTB/POZ-domain C 2 H 2 zinc(Zn)-®nger proteins are encoded by a subfamily of genes related to the Drosophila gap gene kruÈppel. To date, two such proteins, PLZF and LAZ-3/BCL-6, have been implicated in oncogenesis. We have now identi®ed a new member of this gene subfamily which encodes a 62 kDa Zn-®nger protein, termed LRF, with a BTB/POZ domain highly similar to that of PLZF. Both human and mouse LRF genes, which localized to syntenic chromosomal regions (19p13.3 and 10B5.3, respectively), were widely expressed in adult tissues and cell lines. At approximately 9.5 ± 10.0 days of embryonic development, the mouse LRF gene was expressed in the limb buds, pharyngeal arches, tail bud, placenta and neural tube. The LRF protein associated in vivo with LAZ-3/BCL-6, but not with PLZF to which it was more related. Although the LRF, or LAZ-3/BCL-6, BTB/POZ domain could readily homodimerize, no heterodimerization was detected in vivo between the LRF and LAZ-3/BCL-6 BTB/POZ domains and interaction between full length LRF and LAZ-3/BCL-6 required the presence of both the BTB/POZ domain and Zn-®ngers in each partner protein. As expected from the above results, LRF and LAZ-3/BCL-6 also colocalized with each other in the nucleus. Taken together, our ®ndings suggest that BTB/ POZ-domain Zn-®nger proteins may function as homo and heterodimeric complexes whose formation, and hence the resultant eect on transcription of their downstream target genes, is determined by the levels and expression domains of a given partner protein.

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Section: Human and Mouse Cell Linesmentioning

confidence: 99%

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

et al. 1999

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“…Insulin-like growth factors I and I1 [6, 121 and plateletderived growth factor [51] have been implicated as possible growth regulators for human teratoma stem cells derived from the Tera-2 line. These experiments defined growth requirements in serum-fee medium.…”

Section: Preliminary Studies Of the Effect Of Growth Factors And Othementioning

confidence: 99%

Isolation and characterization of a multipotent clone of human embryonal carcinoma cells

et al. 1989

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“…: 0.1 lM), a rat epithelial cell line (Danielpour 1996; v.c. : 0.1 lM), a human teratocarcinoma cell line (Weima et al 1988), a fibrosarcoma cell line (Salbert et al 1993), and in the neuroepithelium of mouse embryos (Mahmood et al 1992;vitamin dose (v.d. ): 12 mg/kg body weight (b.w.…”

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

Vitamin‐regulated cytokines and growth factors in the CNS and elsewhere

Scalabrino

2009

Journal of Neurochemistry

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There is a growing awareness that natural vitamins (with the only exception of pantothenic acid) positively or negatively modulate the synthesis of some cytokines and growth factors in the CNS, and various mammalian cells and organs. As natural vitamins are micronutrients in the human diet, studying their effects can be considered a part of nutritional genomics or nutrigenomics. A given vitamin selectively modifies the synthesis of only a few cytokines and/or growth factors, although the same cytokine and/or growth factor may be regulated by more than one vitamin. These effects seem to be independent of the effects of vitamins as coenzymes and/or reducing agents, and seem to occur mainly at genomic and/or epigenetic level, and/or by modulating NF‐κB activity. Although most of the studies reviewed here have been based on cultured cell lines, but their findings have been confirmed by some key in vivo studies. The CNS seems to be particularly involved and is severely affected by most avitaminoses, especially in the case of vitamin B12. However, the vitamin‐induced changes in cytokine and growth factor synthesis may initiate a cascade of events that can affect the function, differentiation, and morphology of the cells and/or structures not only in the CNS, but also elsewhere because most natural vitamins, cytokines, and growth factors cross the blood–brain barrier. As cytokines are essential to CNS‐immune and CNS‐hormone system communications, natural vitamins also interact with these circuits. Further studies of such vitamin‐mediated effects could lead to vitamins being used for the treatment of diseases which, although not true avitaminoses, involve an imbalance in cytokine and/or growth factor synthesis.

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Differentially regulated production of platelet-derived growth factor and of transforming growth factor beta by a human teratocarcinoma cell line

Cited by 17 publications

References 46 publications

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

Isolation and characterization of a multipotent clone of human embryonal carcinoma cells

Vitamin‐regulated cytokines and growth factors in the CNS and elsewhere

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