In this paper, large-signal output characteristics of the metal-oxide-semiconductor field-effect transistors in the breakdown region are investigated using X-parameter measurements for the first time. Magnitude of X T 2121 coefficients can be larger than the result of X s 2121 coefficients at high input power as drain voltage increases to the breakdown region. The output impedance X z 2121 under large-signal drive incorporating with the X s 2121 and X T 2121 coefficients is derived and then employed to investigate output matching in the breakdown region and at high input power, which is significant for power amplifier designs. Compared with the conventional hot-Z 2121 without X T 2121 coefficients considered, X z 2121 can be more accurate for the output impedance characterization. The presented analysis based on the X-parameters can be beneficial to output matching at high input power for power amplifier designs in the breakdown region.