2018
DOI: 10.1016/j.scib.2017.11.018
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Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes

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Cited by 44 publications
(23 citation statements)
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“…28,29 Few studies have reported the use of nanofibrous-based systems to treat melanoma, namely, by the incorporation of chemotherapeutic drugs (i.e., doxorubicin and imiquimod). 38,39 The use of fucoidan, a natural compound, has never been reported to be immobilized at the surface of electrospun nanofiber meshes. In fact, there are only a few reports where fucoidan has been combined with other polymers during the electrospinning process for tissue regeneration purposes.…”
Section: Discussionmentioning
confidence: 99%
“…28,29 Few studies have reported the use of nanofibrous-based systems to treat melanoma, namely, by the incorporation of chemotherapeutic drugs (i.e., doxorubicin and imiquimod). 38,39 The use of fucoidan, a natural compound, has never been reported to be immobilized at the surface of electrospun nanofiber meshes. In fact, there are only a few reports where fucoidan has been combined with other polymers during the electrospinning process for tissue regeneration purposes.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, myriad of bioactive molecules also has been incorporated in core-shell fibers, typically in core layer. These include drugs [34][35][36][37], natural extracts [38][39][40], proteins [41][42][43], growth factors (GFs) [12,23,44] and even living cells [45][46][47]. Selected combinations of core-shell fibers materials with or without incorporated biomolecules for various tissue engineering and drug delivery applications are listed in Table 1.…”
Section: Designing Core-shell Fibers With View For Biomedical Applicationsmentioning
confidence: 99%
“…Nevertheless, several studies have reported the potential toxicity related to glutaraldehyde [94,96]. Hence, novel cross-linking strategies have been proposed in recent years including use of natural cross-linking agents (e.g., citric acid [97], genipin [35,36], and dextran aldehyde or sucrose aldehyde [49]), atmospheric pressure non-equilibrium plasma treatment [94] and ultraviolet (UV) photo-cross-linking [98][99][100] to solve this limitation.…”
Section: Designing Core-shell Fibers With View For Biomedical Applicationsmentioning
confidence: 99%
“…To establish the xenotransplanted tumor model, 2.0  10 5 CT26 cells were first suspended in 50 lL diluted Matrigel (Corning, USA), and were then subcutaneously injected into the right rear region on the back. Tumor volume was closely monitored using a caliper and calculated according to the formula used in related studies: volume = length  width 2 /2 [25][26][27]. When the tumor size reached 100-120 mm 3 , the following treatments were launched.…”
Section: Animal Models and Experimentationmentioning
confidence: 99%